- Helen Holmes
- Helen (1914-1915) (Episodes 1-48)
- Helen Gibson
- Helen / The Operator at Lone Point (1915-1917)
- J.P. McGowan
- Train Controller / Benton / Rand - Yeggman / Dan Haddon - Cowboy / Brandt - Cashier / Blake - Lineman / Rand - Fireman / Lockwood - Flagman / Warren - Railman / Thomas - Wiretapper Chief / Trow - Wrecking Crewman
- Ethel Clisbee
- Mrs. Benton [Ch. 1] / Mrs. Blake [Ch. 3]
- Pearl Hoxie
- Fanny Benton - the Child [Ch. 1]
- George A. Williams
- Contractor Haddon [Ch. 2] / Tom O'Grady - Section Foreman [Ch. 4] / Constable Duncan - Secret Service Detective (as G.A. Williams)
- William Ehfe
- Gregg - Haddon's Assistant [Ch. 2] / Blake - the Fireman [Ch. 3] / Red Durham - a Yeggman [Ch. 4]
- Paul Hurst
- Benton - a Foreman [Ch. 2]
- Charles Wells
- Benton - an Englineer [Ch. 3]
- Jack Hoxie
- Hanson [Ch. 3]
- Leo D. Maloney
- Duncan [Ch. 4] / Billy Melville - Conductor [Ch. 5] / Dick Malling - Aeronaut [Ch. 6] / Sheridan - Railroad Detective [Ch. 7]
- M.J. Murchison
- Mike Keenan - Red's Pal [Ch. 4] / Flint - a Yeggman [Ch. 5] / Broden
- R.S. Antibus
- Brent - a Fence [Ch. 5]
- George Routh
- The Superintendent
- True Boardman
- Jerry [Ch. 58]
- Clarence Burton
- Layson
- J. Gunnis Davis
- Pete
- Hoot Gibson
- Messenger / Etzer (as Hall Gibson) (as Edward Gibson)
- Clement Graw
- Pinture - the Fireman
- Franklyn Hall
- Odell - an Engineer
- Ben Jones
- Trainman
- Elsie MacLeod
- Rita - Telegraph Operator [Ch. 27]
- Anna Q. Nilsson
- Helen [Ch. 18] 'The Night Operator at Buxton'
- Edward Roberts
- (as E.Z. Roberts)
- Norma Thelan
- (as Norma Antibus)
- Tom Trent
- Bobbie [Ch. 59]
- N.Z. Wood
- (as N.Z. Woods)
