- Blair Underwood
- Gregory Fletcher / The Golden Blaze (voice)
- Michael Clarke Duncan
- Thomas Tatum / Quake (voice)
- Sanaa Lathan
- Monica
- Neil Patrick Harris
- The Comic Shop Owner
- Khleo Thomas
- Jason / Sure Shot (voice)
- Rickey D'Shon Collins
- Leon
- Kym Whitley
- Mother Johnson
- James Mathis III
- Comic Narrator / Diner / Astronaut 1 / Red Car Guy / Clerk / Camera Man (voice) (as James C. Mathis III)
- Nick Jameson
- Principal / Scientist (voice) (as Nick Jamison)
- Vanessa Marshall
- Honohan / Pharmacist Mom / Cindy / TV News Anchor / Goon Boy 1 (voice)
- Quinton Flynn
- French Waiter / Kid 3 / Goon Boy 2 (voice)
- Leon Lozano
- Motorcycle Thug
