- Jerry Lewis
- Willard Woodward / James Peyton / Everett Peyton / Julius Peyton / Capt. Eddie Peyton / Skylock Peyton / 'Bugs' Peyton
- Sebastian Cabot
- Dr. Matson
- Neil Hamilton
- Attorney
- Jay Adler
- Mr. Lyman, Attorney
- Robert Strauss
- Pool Hall Owner
- Jesslyn Fax
- Airline Passenger
- Renie Riano
- Airline Passenger
- Ellen Corby
- Airline Passenger
- Frances Weintraub Lax
- Airline Passenger
- Marjorie Bennett
- Airline Passenger
- Herbie Faye
- Joe
- Milton Frome
- Pilot
- Gene Baylos
- Clown
- Donna Butterworth
- Donna Peyton
- John Lawrence
- Chief Petty Officer
- Francine York
- Air Hostess
- John Hubbard
- Second Pilot
- Michael Ross
- Second Guard
- John Macchia
- Univac Operator
- Douglas Deane
- Male Model
- Maurice Kelly
- Shoe Salesman
- Vince Barnett
- Oil Change Customer
- Anne Baxter
- Actress in In-Flight Movie
- Eve Bruce
- Model
- Henry Corden
- Gasoline Truck Driver
- Scatman Crothers
- Airport Employee
- Ted Eccles
- (uncredited)
- Douglas Evans
- (uncredited)
- Norman Leavitt
- Carl - Gas Station Manager
- Gary Lewis
- Gary Lewis - Leader of Band aboard the Trimotor
- Edwin Max
- Pool Hall Patron
- Gerald Mohr
- Actor in In-Flight Movie
- Robert Nunn
- Boy at Gas Station
- Benny Rubin
- Sign Painter
- Joan Swift
- Airline Stewardess
- William Wellman Jr.
- F.B.I. Agent
