- Lucero
- Self - Hostess
- Cristián de la Fuente
- Self - Host
- Pepe Aguilar
- Self - Nominee / Performer
- Marc Anthony
- Self - Performer
- Anand Bhatt
- Self
- Angelique Boyer
- Self - Presenter
- Cabra
- Self
- Calle 13
- Themselves - Performer / Winner
- Cristian Castro
- Self - Performer
- Carlos Chavez
- Self
- Franco de Vita
- Self - Performer / Winner
- Chiquinquirá Delgado
- Self - Presenter
- Eugenio Derbez
- Self
- Sandra Echeverría
- Self - Presenter
- Erik Estrada
- Self - Presenter
- Paula Fernandes
- Self - Performer / Nominee
- Alejandra Guzmán
- Self - Performer
- Sean Kingston
- Self
- Colby Lemmo
- Dancer
- Demi Lovato
- Self - Performer
- Camila Luna
- Self
- Adamari López
- Self - Presenter
- Maná
- Themselves - Performer / Winner
- Ricky Martin
- Self - Performer & Nominee
- Silvia Navarro
- Self - Presenter
- Pitbull
- Self - Performer / Nominee
- Dionne Renée
- Dancer (Shakira)
- Residente
- Self
- Prince Royce
- Self - Performer
- Paulina Rubio
- Self - Presenter
- Sebastián Rulli
- Self - Presenter
- Zoe Saldana
- Self - Presenter
- Romeo Santos
- Self - Performer
- Shakira
- Self - Performer / Winner
- Sie7e
- Self - Performer / Winner
- Marco Antonio Solís
- Self - Performer / Winner
- Blanca Soto
- Self - Presenter
- Usher
- Self - Performer
- Sofía Vergara
- Self - Presenter
- Wisin & Yandel
- Themselves - Performer / Nominee
- David Zepeda
- Self - Presenter
- Diego Alfonso
- Self - Audience Member
- Soledad Fandiño
- Self - Audience Member
