- Maurice Murphy
- Tailspin Tommy Tompkins
- Noah Beery Jr.
- Skeeter Milligan
- Patricia Farr
- Betty Lou Barnes
- Walter Miller
- Bruce Hoyt
- Grant Withers
- Milt Howe
- Charles A. Browne
- Paul Smith
- Bryant Washburn
- Mr. Grant - Film Director of 'Midnight Patrol', Chs. 10-12
- Belle Daube
- Mrs. Martha Tompkins, Tommy's Mother - Chs. 1, 12
- John Davidson
- Wade 'Tiger' Taggart
- Harrison Greene
- Air Circus Announcer [Ch. 2]
- William Desmond
- Sloane - Taggart's Office Henchman, Chs. 4, 7, 10-11
- Lew Kelly
- Victor Martin - Three Point Airport Dispatcher
- John Ince
- Eric Peabody [Chs. 3-5]
- Lee Beggs
- Deacon Grimes [Chs. 1,12]
- Ethan Laidlaw
- Bart Dirk, Henchman
- Dennis Moore
- Pilot Herb Slack
- Edmund Cobb
- Pilot 'Speed' Walton
- Jack Leonard
- Al, Skinny Mechanic
- Monte Montague
- Cliff, Hefty Mechanic
- Rita Rozelle
- Mary Dale - Actress in 'Midnight Patrol', Ch. 10
- Beulah Hutton
- Sloane's Ambassador Club Date
- Gertrude Astor
- Fake Office Nurse / Taggart's Date - Chs. 7, 9
- Jimmie Grier
- Jimmy Grier- Orchestra Leader, from Cohens and Kellys in Hollywood (1932)
- Dennis O'Keefe
- Dance Extra, from Cohens and Kellys in Hollywood (1932)
- King Baggot
- Airplane Inspector [Ch. 1]
- Walter Brennan
- Hospital Orderly Slugged by Skeeter [Ch. 8]
- Lynton Brent
- Jack Bradley
- Don Brodie
- Man at Airport with Automobile [Ch. 9]
- Horace B. Carpenter
- Postmaster Jed Purdy [Chs. 1, 12]
- Jim Corey
- Curly's Driver Henchman (Chs. 7-8)
- Richard Cramer
- Kelly
- Anne Darling
- Nurse [Ch. 8]
- Edgar Dearing
- 2nd Whistle-blowing Policeman
- George DeNormand
- George - Denver Official, Ch. 6
- Walter Fabian
- Bevan
- Al Ferguson
- Henchman Spider - Chs. 3-7, 9
- Richard Fryer
- Fryer - Midnight Patrol Movie Cameraman, Chs. 10-12
- Chester Gan
- Flapjack - the Cook, Ch. 1
- William Gould
- Sheriff of Starbuck [Ch. 11]
- Pat Harmon
- El Paso Official - Ch. 6
- Otto Hoffman
- Dr. Krantz, Chemist [Ch. 4-5]
- Allen Holbrook
- Possee Sheriff (Chs. 4-5)
- Lois January
- Mrs. Grant
- Tiny Jones
- Wardrobe Woman, Venture Pictures
- Jack 'Tiny' Lipson
- Hefty Extra in Cafe [Ch. 5]
- George Magrill
- Henchman Bailey [Chs. 4, 6-7]
- Jack Mower
- Police Captain Jones [Ch. 12]
- Charles Murphy
- Henchman-Mechanic Grease Rowley / Train Flagman (uncredited)
- Bud Osborne
- Pug Nelson. Henchman-Mechanic
- Rose Plumer
- Mother's Train Companion [Chs. 11-12]
- Dick Rush
- Policeman at Earthquake (Ch. 10)
- Nick Thompson
- Henchman Curly (Chs. 7-8)
- Slim Whitaker
- Henchman Charlie - Chs. 6-7
- Jane Withers
- Mary Elizabeth
- William Worthington
- Denver Doctor [Ch. 6]
