- Edward Arnold
- Johan (John) Sutter
- Lee Tracy
- Pete Perkin
- Binnie Barnes
- Countess Elizabeth Bartoffski
- Katharine Alexander
- Anna Sutter
- Montagu Love
- Capt. Kettleson
- Addison Richards
- James Marshall
- John Miljan
- Gen. Juan Bautista Alvarado
- Harry Carey
- Kit Carson
- William Janney
- John Sutter Jr.
- Nan Grey
- Ann Eliza Sutter
- Robert Warwick
- Gen. Alexander Rotscheff
- Morgan Wallace
- General Fremont
- Allen Vincent
- Juan Bautista Alvarado Jr.
- Mitchell Lewis
- King Kamehameha
- Stanley Andrews
- Senator Rand
- Oscar Apfel
- Bartender
- Frank Austin
- Settler-Miner in Bar
- John Bleifer
- Guerino
- Harry Bowen
- San Francisco Mob Leader
- Sidney Bracey
- Smythe - Sutter's Accountant
- Ed Brady
- Sailor
- Donald Briggs
- Soldier
- Tommy Bupp
- First Newsboy
- Eddy Chandler
- Rider / Messenger (uncredited)
- Wallis Clark
- Defense Attorney
- Harry Cording
- Seaman Lars
- Ronnie Cosby
- John Sutter Jr. - Age 8
- Richard Cramer
- Miner
- Frank Darien
- Missouri Trader
- Aura de Silva
- Señora Alvarado
- Neely Edwards
- Townsman
- Chester Gan
- Charlie - Chinese Waiter
- Edward Gargan
- Wagon Driver
- Billy Gilbert
- Gen. Ramos
- Gaston Glass
- Lt. Bacalenakoff
- William Gould
- Captain Jensen
- Jonathan Hale
- Prosecuting Attorney
- Russell Hopton
- Crazed Sailor
- Olaf Hytten
- Johann, Waiter
- Lloyd Ingraham
- San Francisco Committee Man
- George Irving
- Dr. Billings
- Dickie Jones
- 2nd Newsboy
- Al Kikume
- Hawaiian
- Charles King
- San Francisco Committee Man
- John 'Dusty' King
- Alvarado Jr. (replaced by Allen Vincent)
- Priscilla Lawson
- Mexican Waitress
- Andrea Leeds
- Nurse
- George Lloyd
- Bo'sun
- Walter Long
- Sailor
- Jim Mason
- Miner
- Frank Mayo
- Miner in Bar
- Bud Osborne
- Rider with Carson
- John Picorri
- Mexican Officer
- Russ Powell
- Brown
- Pedro Regas
- De La Cruz
- Frank Reicher
- Governor Felipe Vega
- Constantine Romanoff
- Bald Tallest Seaman - Slave Ship
- José Rubio
- Man
- William Ruhl
- Aide
- Tiny Sandford
- San Francisco Troublemaker
- Albert J. Smith
- Man
- Joanne Smith
- Ann Eliza Sutter - Age 3
- Ray Spiker
- Seaman
- Harry Strang
- General Fremont's Scout
- Harry Stubbs
- John Jacob Astor
- Phil Tead
- Lewis's Secretary
- Jim Thorpe
- Miner
- Guy Usher
- Swiss Police Prefect Wache
- Lucio Villegas
- Mexican Officer
- Frederik Vogeding
- Conspirator at Inn
- Bryant Washburn
- Capt. Petroff
- Delmar Watson
- 3rd Newsboy
- Paul Weigel
- Townsman
- Clarence Wilson
- Streetcar Owner
