- Bobby Ellerbee
- Â Sheriff 132 episodes, 2005-2021
- Dana Snyder
- Â Granny / ... 131 episodes, 2005-2021
- Daniel McDevitt
- Â Rusty Cuyler / ... 129 episodes, 2005-2021
- Unknown Hinson
- Â Early Cuyler / ... 124 episodes, 2005-2019
- Dave Willis
- Â Narrator / ... 106 episodes, 2005-2021
- Todd Hanson
- Â Dan Halen 55 episodes, 2005-2021
- Mary Kraft
- Â Krystal / ... 38 episodes, 2005-2021
- Patricia French
- Â Aunt Lil 38 episodes, 2005-2021
- Scott Hilley
- Â Reverend 36 episodes, 2005-2014
- Pete Smith
- Â Boyd 29 episodes, 2005-2016
- Shawn Coleman
- Â Clown Boy / ... 29 episodes, 2005-2021
- Fred Armisen
- Â Jesus / ... 18 episodes, 2005-2011
- Charles Napier
- Â Sheriff 9 episodes, 2005-2006
- Tracy Morgan
- Â Early Cuyler 9 episodes, 2021
- Brendon Small
- Â Dr. Jerry / ... 8 episodes, 2005-2012
- Dana Swanson
- Â Glenn's Wife 8 episodes, 2008-2017
- Ned Hastings
- Â Judge 7 episodes, 2006-2017
- Elizabeth Cook
- Â Tammy / ... 6 episodes, 2011-2021
- Jason Isbell
- Â Pastor Nubbins / ... 6 episodes, 2016-2021
- Jesco White
- Â Ga-Ga-Pee-Pap Cuyler / ... 6 episodes, 2010-2021
- Niko Coleman
- Â Randy 5 episodes, 2014-2017
- Doug Richards
- Â Doug Richards / ... 5 episodes, 2012-2017
- Nick Ingkatanuwat
- Â Billy Morton 5 episodes, 2005-2011
- Todd Barry
- Â Dr. Bug / ... 4 episodes, 2005-2014
- Riley Martin
- Â Dan Halen's Conscience / ... 4 episodes, 2008-2011
- Max Willis
- Â Baby Taco Baby / ... 4 episodes, 2005-2016
- Ellis Walden
- Â Galactacon Fracking Boss / ... 3 episodes, 2012-2013
- Dave Stone
- Â Brock Bill 3 episodes, 2011-2013
- Mike Schatz
- Â Counselor / ... 3 episodes, 2006-2016
- Billie Reaves
- Â Sheriff's Mom / ... 3 episodes, 2006-2012
- Tim Andrews
- Â Homicidal GPS 3 episodes, 2010-2017
- Phil Samson
- Â CIA Guy 2 episodes, 2005-2006
- Jon Wurster
- Â Dakota the Hippie 2 episodes, 2006-2008
- George Lowe
- Â Wrestling Promo Announcer 2 episodes, 2009-2010
- Phil Hendrie
- Â Football Coach / ... 2 episodes, 2010-2019
- Matt Foster
- Â Tattoo Artist 2 episodes, 2012-2016
- Isaac Hayes III
- Â Prisoner 2 episodes, 2014-2017
- Winford Warren
- Â Doctor / ... 2 episodes, 2016
- Laurie Catherine Winkel
- Â Cooler / ... 2 episodes, 2019
- Eric Butterbean Esch
- Â Self 1 episode, 2008
- Don Barnes
- Â Self 1 episode, 2006
- Andrew Montesi
- Â Festival of the Clown Freak Ad Announcer 1 episode, 2010
- Paul Painter
- Â Radio deejay 1 episode, 2016
- Armando Rinconia
- Â Authentic Mexican 1 episode, 2005
- Danny Chauncey
- Â Self 1 episode, 2006
- Todd Snider
- Â Lobster Freak 1 episode, 2010
- Alexandra Ficken
- Â Holiday Barista 1 episode, 2017
- Larry Junstrom
- Â Self 1 episode, 2006
- Mamie White
- Â Krystal's Cousin 1 episode, 2010
- Larry Wachs
- Â Clown 1 episode, 2010
- Kevin Gillespie
- Â Self 1 episode, 2011
- Amanda Marks
- Â Donna 1 episode, 2005
- Larry Munson
- Â God 1 episode, 2008
- Widespread Panic
- Â Themselves 1 episode, 2010
- T-Pain
- Â Self 1 episode, 2011
- Jared Swilley
- Â Self 1 episode, 2013
- Ralphie May
- Â Pnut 1 episode, 2013
- Bradford Cox
- Â Self 1 episode, 2013
- Victoria Cook
- Â Darla 1 episode, 2013
- Lavell Crawford
- Â Judge Jammer 1 episode, 2013
- Patton Oswalt
- Â One-Eyed Squid 1 episode, 2006
- Jonathan Katz
- Â The Therapist 1 episode, 2006
- Brooks Braselman
- Â Fake Patrick Swayze 1 episode, 2006
- Jason Mantzoukas
- Â Pine Booby 1 episode, 2008
- Rachel Dratch
- Â Hippie Woman 1 episode, 2008
- Vernon Chatman
- Â Shuckey the Corn Mascot 1 episode, 2008
- Greg Hollimon
- Â Pine Booby Leader 1 episode, 2008
- A. Smith Harrison
- Â Dr. Horny / ... 1 episode, 2009
- Paul Stanley
- Â Self 1 episode, 2010
- Chad Johnson
- Â Self 1 episode, 2010
- John Bell
- Â Self 1 episode, 2010
- Jimmy Herring
- Â Self 1 episode, 2010
- Domingo S. Ortiz
- Â Self 1 episode, 2010
- John 'Jojo' Hermann
- Â Self 1 episode, 2010
- Dave Schools
- Â Self 1 episode, 2010
- Todd Nance
- Â Self 1 episode, 2010
- Billy Joe Shaver
- Â Customs Agent / ... 1 episode, 2011
- George Robinson
- Â Snow Daddy 1 episode, 2011
- Ryuu Sato
- Â Rusty Cuyler (Japanese dub) 1 episode, 2011
- The Mighty Ohba
- Â Early Cuyler (Japanese dub) 1 episode, 2011
- Anthony 'Citric' Campos
- Â Rodrigo 1 episode, 2014
- Joe Thomas
- Â Chairman 1 episode, 2014
- Amber Nash
- Â Prosperity 1 episode, 2016
- Leslie Sharp
- Â Vicki 1 episode, 2016
- Coolio
- Â Self 1 episode, 2017
- Jason 'Wee Man' Acuña
- Â Self 1 episode, 2017
- Anna Vocino
- Â Innocence Project Lawyer 1 episode, 2017
- Tony Guerrero
- Â Prisoner 1 episode, 2017
- JD McPherson
- Â Prisoner 1 episode, 2017
- Shooter Jennings
- Â Shooter Jennings 1 episode, 2019
- Steve Earle
- Â Steve Earle 1 episode, 2019
- Lucinda Williams
- Â Lucinda Williams 1 episode, 2019
- Aaron M.G. Miller
- Â Man on Hayride 1 episode, 2019
- Tasha Carlson
- Â Female in vehicle at the fruit stand 1 episode, 2019
- Nicki Lane
- Â Nicki Lane 1 episode, 2019
- David Allan Coe
- Â Self (uncredited) 1 episode, 2008
- Mick Foley
- Â Thunderclap (uncredited) 1 episode, 2009
- Will Forte
- Â Tom Treebow (uncredited) 1 episode, 2010