- George Lowe
- Â Space Ghost / ... 114 episodes, 1993-2012
- C. Martin Croker
- Â Zorak / ... 113 episodes, 1994-2012
- Andy Merrill
- Â Brak / ... 30 episodes, 1993-2003
- Dave Willis
- Â Self / ... 21 episodes, 1996-2003
- Don Kennedy
- Â Tansut / ... 21 episodes, 1994-1999
- Bobcat Goldthwait
- Â Self 2 episodes, 1994-2002
- Judy Tenuta
- Â Black Widow / ... 6 episodes, 1994-1997
- Willie Nelson
- Â Self 5 episodes, 2001-2003
- Scott Finnell
- Â Birdman 3 episodes, 1996-1999
- Matt Maiellaro
- Â Self / ... 4 episodes, 1998-2003
- Scott Prendergast
- Â Red Guy 5 episodes, 2003
- Brad Abelle
- Â Chad Ghostal 4 episodes, 1995-1997
- James Kirkconnell
- Â Kirk the Storyteller / ... 4 episodes, 1995-1999
- Jim Fortier
- Â Carl / ... 3 episodes, 1997-1999
- Chip Duffey
- Â Banjo / ... 3 episodes, 1995-1997
- Mike Lazzo
- Â Self / ... 3 episodes, 1999-2002
- Peter Fonda
- Â Self 2 episodes, 1997
- Merrill Markoe
- Â Self 2 episodes, 1997-1998
- John Henson
- Â Self 2 episodes, 1997-1998
- Buzz Aldrin
- Â Self 2 episodes, 1997
- Gary Owens
- Â Announcer / ... 2 episodes, 1996-1998
- Bruce Taylor
- Â 1966 Voice / ... 2 episodes, 1997-1998
- Matt Harrigan
- Â Jace 2 episodes, 1998
- Dian Parkinson
- Â Self 2 episodes, 1994-1995
- Tom Arcuragi
- Â Bob 2 episodes, 1997
- Tanya Bergan
- Â Announcer / ... 2 episodes, 1994
- Oliver Nichols
- Â Mail Room Guy 2 episodes, 1996-1998
- Ken Osborn
- Â Announcer / ... 2 episodes, 1996-1997
- Keith Crofford
- Â MOE 2000 2 episodes, 1995-1996
- Khaki Jones
- Â Female CD Commercial Announcer 2 episodes, 1994-1995
- Jim Rich
- Â Narrator 2 episodes, 1995
- Kevin Meaney
- Â Self 2 episodes, 1994
- Lori Fetrick
- Â Ice 2 episodes, 1996-1997
- 'Weird Al' Yankovic
- Â Self 1 episode, 1994-1997
- Mark McEwen
- Â Self 2 episodes, 1996-1998
- Steve Henneberry
- Â Tower 2 episodes, 1996-1997
- David L. Lander
- Â Self 1 episode, 1997
- Cheryl Barbour
- Â Selfhelp Tape / ... 2 episodes, 1997-1998
- Gus Jordan
- Â Moltar / ... 2 episodes, 1996-1997
- Pete Smith
- Â Banjo 2 episodes, 1996-1998
- Isabel Gonzalez
- Â Fran Drescher / ... 2 episodes, 1996-1998
- Russell Johnson
- Â Self 2 episodes, 1994-1995
- Barry Mills
- Â Colonial Doorman 2 episodes, 1995-2003
- Rob Scoggins Jr.
- Â Friend 2 episodes, 1994-1995
- Kaili Rubin
- Â Banjo / ... 1 episode, 1996-1997
- Joyce Brothers
- Â Self 1 episode, 1994
- Branford Marsalis
- Â Self 1 episode, 1994
- Cindy Guyer
- Â Self 1 episode, 1994
- Schoolly D
- Â Self 1 episode, 1994
- Jim Carrey
- Â Self 2 episodes, 1995
- Catherine Bach
- Â Self 1 episode, 1995
- Hulk Hogan
- Â Self 1 episode, 1995
- Craig McCracken
- Â Self 1 episode, 1995
- David Byrne
- Â Self 1 episode, 1995
- Michael Stipe
- Â Self 1 episode, 1995
- Janeane Garofalo
- Â Self 1 episode, 1996
- Terry Jones
- Â Self 1 episode, 1996
- Susan Olsen
- Â Self 1 episode, 1996
- Scott 'Carrot Top' Thompson
- Â Self 1 episode, 1996
- James Hetfield
- Â Self 1 episode, 1996
- Matt Groening
- Â Self 1 episode, 1996
- Penn Jillette
- Â Self 1 episode, 1996
- Laurie Anderson
- Â Self 1 episode, 1996
- Jonathan Richman
- Â Self 1 episode, 1996
- Emeril Lagasse
- Â Self 1 episode, 1996
- Thurston Moore
- Â Fred Cracklin 1 episode, 1996
- Michael Norman
- Â Self 1 episode, 1996
- Michael McKean
- Â Self 1 episode, 1997
- Bob Odenkirk
- Â Self 1 episode, 1997
- Charlton Heston
- Â Self 1 episode, 1997
- Mike Judge
- Â Self 1 episode, 1997
- Ice-T
- Â Self 1 episode, 1997
- Rob Zombie
- Â Self 1 episode, 1997
- Bill Mumy
- Â Self 1 episode, 1997
- Jon Stewart
- Â Jon Stewart 1 episode, 1997
- Pat Boone
- Â Self 1 episode, 1997
- Steve Allen
- Â Self 1 episode, 1997
- George Clinton
- Â Self 1 episode, 1997
- Beck
- Â Self 1 episode, 1997
- Robin Leach
- Â Self 1 episode, 1997
- Jimmy Cliff
- Â Self 1 episode, 1997
- Fred Schneider
- Â Self 1 episode, 1997
- Michael Cudahy
- Â Self 1 episode, 1997
- Bob Abdou
- Â Self 1 episode, 1997
- Maxcy Nolan
- Â Self 1 episode, 1997
- Ben Stiller
- Â Self 1 episode, 1998
- Garrett Morris
- Â Self 1 episode, 1998
- Michael Moore
- Â Self 1 episode, 1998
- Tyra Banks
- Â Self 1 episode, 1998
- Jeff Foxworthy
- Â Self 1 episode, 1998
- Drew Pinsky
- Â Self 1 episode, 1998
- Moby
- Â Self 1 episode, 1998
- Greta Van Susteren
- Â Self 1 episode, 1998
- H. Jon Benjamin
- Â Self 1 episode, 1999
- Conan O'Brien
- Â Conan O'Brien 1 episode, 1999
- Al Roker
- Â Self 1 episode, 1999
- Jerry Springer
- Â Self 1 episode, 1999
- Isaac Hanson
- Â Self 1 episode, 1999
- Jack Black
- Â Self 1 episode, 2001
- Björk
- Â Self 1 episode, 2001
- Dave Thomas
- Â Self 1 episode, 2001
- Busta Rhymes
- Â Self 1 episode, 2001
- William Shatner
- Â Self 1 episode, 2003
- Dennis Miller
- Â Self 1 episode, 2003
- Jeff Probst
- Â Self 1 episode, 2003
- Todd Barry
- Â Self 1 episode, 2003
- Robert Smigel
- Â Triumph the Insult Comic Dog 1 episode, 2004
- Emma Thompson
- Â Self 1 episode, 1993
- Danny Bonaduce
- Â Self 1 episode, 1994
- Rich Hall
- Â Self 1 episode, 1994
- Kamal Ahmed
- Â Self 1 episode, 1994
- Donny Osmond
- Â Self 1 episode, 1995
- Chuck Russell
- Â Self 2 episodes, 1995
- Slash
- Â Self 1 episode, 1995
- Lassie
- Â Lassie 1 episode, 1995
- Matthew Sweet
- Â Self 1 episode, 1995
- Patrick A. Ventura
- Â Self 1 episode, 1995
- Carl Clark
- Â Carl the Cartoonist 2 episodes, 1995
- Cassandra Peterson
- Â Elvira 1 episode, 1996
- Dave Grohl
- Â Self 1 episode, 1996
- Bill Nye
- Â Self 1 episode, 1996
- Teller
- Â Self 1 episode, 1996
- Kirk Hammett
- Â Self 1 episode, 1996
- Glen Phillips
- Â Self 1 episode, 1996
- Stomp
- Â Themselves 1 episode, 1996
- Nathalie Dupree
- Â Self 1 episode, 1996
- Mark Hamill
- Â Self 1 episode, 1997
- David Cross
- Â Self 1 episode, 1997
- Harland Williams
- Â Self 1 episode, 1997
- Raven-Symoné
- Â Self 1 episode, 1997
- Erik Estrada
- Â Self 1 episode, 1997
- Andy Dick
- Â Self 1 episode, 1997
- Chuck D
- Â Self 1 episode, 1997
- Bob Goen
- Â Self 1 episode, 1997
- Sam Butera
- Â Self 1 episode, 1997
- Ernie C
- Â Self 1 episode, 1997
- Steve Arnold
- Â Self 1 episode, 1997
- Pete Michael
- Â Self 1 episode, 1997
- Jack Logan
- Â Self 1 episode, 1997
- Rebecca Romijn
- Â Self 1 episode, 1998
- Kevin Smith
- Â Self 1 episode, 1998
- Adam Carolla
- Â Self 1 episode, 1998
- Emo Philips
- Â Self 1 episode, 1998
- Marc Weiner
- Â Self 1 episode, 1998
- Joey Googe
- Â Joey 1 episode, 1998
- Sarah Jessica Parker
- Â Self 1 episode, 1999
- Bob Costas
- Â Self 1 episode, 1999
- Taylor Hanson
- Â Self 1 episode, 1999
- Kyle Gass
- Â Self 1 episode, 2001
- Thom Yorke
- Â Self 1 episode, 2001
- Chris Gore
- Â Self 1 episode, 1993
- John G. Brennan
- Â Self 1 episode, 1994
- Anka Radakovich
- Â Self 1 episode, 1994
- Jacqueline Jusko
- Â Your Mother 1 episode, 1994
- Cecilia Maza
- Â Spanish Translator 1 episode, 1994
- Van Partible
- Â Self 1 episode, 1995
- Mujibur Rahman
- Â Self 1 episode, 1995
- Joel Hodgson
- Â Self 1 episode, 1996
- Martin Yan
- Â Self 1 episode, 1996
- Wylie Gustafson
- Â Self 1 episode, 1996
- Flip Orley
- Â Self 1 episode, 1996
- Fred Willard
- Â Self 1 episode, 1997
- Russ Powell
- Â Self 1 episode, 1997
- Jim Jarmusch
- Â Self 1 episode, 1998
- Shirley Manson
- Â Self 1 episode, 1998
- Zac Hanson
- Â Self 1 episode, 1999
- Adam West
- Â Adam West 1 episode, 1994
- Fran Drescher
- Â Self 1 episode, 1995
- Sirajul Islam
- Â Self 1 episode, 1995
- Gene Mattos
- Â Self 1 episode, 1995
- John Popper
- Â Self 1 episode, 1996
- Bill Manspeaker
- Â Marshall 'Duh' Staxx 1 episode, 1996
- Bruce Hampton
- Â Warren 1 episode, 1998
- Corri English
- Â Galaxy Girl 1 episode, 1999
- Lee Meriwether
- Â Self 1 episode, 1994
- Genndy Tartakovsky
- Â Self 1 episode, 1995
- Carol Channing
- Â Self 1 episode, 1995
- Randy Savage
- Â Leonard Ghostal 1 episode, 1997
- Gregory Harrison
- Â Roy Allen 1 episode, 1998
- Daryl Dragon
- Â The Captain 1 episode, 1999
- David Bennett
- Â Chambraigne Announcer 1 episode, 1999
- Eartha Kitt
- Â Self 1 episode, 1994
- Alice Cooper
- Â Self 1 episode, 1995
- John Peel
- Â Announcer 1 episode, 1996
- Mabel Isler
- Â Mom Ghostal 1 episode, 1996
- Toni Tennille
- Â Self 1 episode, 1999
- Jon Schnepp
- Â C. Ling Tile 1 episode, 1999
- Amy Handler
- Â Tooth Fairy 1 episode, 1999
- Chris Harmon
- Â Lava Narrator 1 episode, 1994
- Michael Tew
- Â Metallus 1 episode, 1994
- Dennis Mehiel
- Â Sal 1 episode, 1995
- Penny Jones
- Â Space Ghost's Mom 1 episode, 1996
- John Bernstein
- Â 60s Space Ghost 1 episode, 1997
- Mark Banker
- Â Self - Musical Fanfare 1 episode, 1999
- Brian Welch
- Â Mookie 1 episode, 1995
- Joseph Dursun
- Â Whoosh! 1 episode, 1996
- Bonnie Rosmarin
- Â Teacher 1 episode, 1999
- Denzel Washington
- Â Self 1 episode, 1993
- Ashley Judd
- Â Self 1 episode, 1994
- Dawn Wells
- Â Self 1 episode, 1994
- Bob Denver
- Â Self 1 episode, 1994
- Barry Gibb
- Â Self 1 episode, 1994
- Robin Gibb
- Â Self 1 episode, 1994
- Maurice Gibb
- Â Self 1 episode, 1994
- Timothy Leary
- Â Self 1 episode, 1994
- Susan Powter
- Â Self 2 episodes, 1994-2004
- Joe Franklin
- Â Self 1 episode, 1994
- Bill Carter
- Â Self 1 episode, 1994
- Sandra Bernhard
- Â Self 1 episode, 1995
- Eugene Mattos
- Â Self 1 episode, 1995
- B. Palmer Mills
- Â Self 1 episode, 1995
- Cameron Diaz
- Â Cameron Diaz 1 episode, 1996
- Method Man
- Â Self 1 episode, 1996
- Jimmie 'JJ' Walker
- Â Self 1 episode, 1996
- Wes Johnson
- Â Self 1 episode, 1996
- Ben Folds
- Â Self 1 episode, 1996
- Les Claypool
- Â Self 1 episode, 1996
- Juliana Hatfield
- Â Self 1 episode, 1996
- Pat DiNizio
- Â Self 1 episode, 1996
- Robert Bakker
- Â Self 1 episode, 1996
- Mike Watt
- Â Self 1 episode, 1996
- Vinnie Dombroski
- Â Self 1 episode, 1996
- Larry Lalonde
- Â Self 1 episode, 1996
- Sean Gooden
- Â Bobcat Goldthwait 1 episode, 1996
- Scott Lipe
- Â Michael Stipe 1 episode, 1996
- Gill Austin
- Â Banjo 1 episode, 1996
- Jill Cunniff
- Â Self 1 episode, 1996
- Jefferson Clay
- Â Zorak 1 episode, 1996
- Norbert St. Louis
- Â Self 1 episode, 1996
- Dennis Diken
- Â Self 1 episode, 1996
- Rodney Trevon Oliver
- Â Self 1 episode, 1996
- Matt Talbott
- Â Self 1 episode, 1996
- Goldie Hawn
- Â Self 1 episode, 1997
- Tommy Davidson
- Â Self 1 episode, 1997
- Colin Quinn
- Â Self 1 episode, 1997
- Steve Smith
- Â Red Green 1 episode, 1997
- Stephen Malkmus
- Â Self - Pavement 1 episode, 1997
- Scott Kanberg
- Â Self - Pavement 1 episode, 1997
- Mark Ibold
- Â Self - Pavement 1 episode, 1997
- Steve West
- Â Self - Pavement 1 episode, 1997
- Bob Nastanovich
- Â Self - Pavement 1 episode, 1997
- Denis Leary
- Â Self 1 episode, 1998
- Tom Arnold
- Â Self 1 episode, 1998
- Kathy Kinney
- Â Self 1 episode, 1998
- Annabelle Gurwitch
- Â Self 1 episode, 1998
- Tony Bennett
- Â Self 1 episode, 1998
- MacInTalk
- Â Warren's monitor 1 episode, 1998
- Paul Gilmartin
- Â Self 1 episode, 1998
- John Flansburgh
- Â Self 1 episode, 1998
- King William
- Â Self 1 episode, 1998
- Sean Medlock
- Â Self 1 episode, 1998
- Afro-Plane
- Â Themselves 1 episode, 1998
- Ginny
- Â Self 1 episode, 1998
- Ryah Rosenberg
- Â Self 1 episode, 1998
- Sharon Willis
- Â Self 1 episode, 2001
- Rachel Maiellaro
- Â Self 1 episode, 2001
- Harriet Lazzo
- Â Self 1 episode, 2001
- Kenny Wayne Shepherd
- Â Self 1 episode, 2006
- Billy Mitchell
- Â Self 1 episode, 2006
- Rand Miller
- Â Self 1 episode, 2006
- Al Alcorn
- Â Mr. Pong 1 episode, 2006
- Steve Wozniak
- Â Self 1 episode, 2007
- Wayne Coyne
- Â Self 1 episode, 2007
- Chantal Claret
- Â Self 1 episode, 2007
- Richard Garriott
- Â Self 1 episode, 2007
- Howard Scott Warshaw
- Â Self 1 episode, 2007
- Stephen Bristow
- Â Self 1 episode, 2007
- Rob Fulop
- Â Self 1 episode, 2007
- Larry Hunter
- Â Self 1 episode, 2007
- David Crane
- Â Self 1 episode, 2007
- Dee Snider
- Â Self 1 episode, 2008
- Barenaked Ladies
- Â Themselves 1 episode, 2008
- Bruce Stern
- Â Self 1 episode, 2008
- Zoe Saldana
- Â Self 1 episode, 2009
- Tommy Wiseau
- Â Self 1 episode, 2011
- Will Ferrell
- Â Self 1 episode, 2012
- Zach Galifianakis
- Â Self 1 episode, 2012
- Ramones
- Â Themselves (uncredited) 1 episode, 1994
- Ameenah Kaplan
- Â Self (uncredited) 1 episode, 1996
- Chad Kukahiko
- Â Self (uncredited) 1 episode, 1996
- Steven Wright
- Â Self (uncredited) 1 episode, 1999
- Chris Ward
- Â Dancing Man (uncredited) 1 episode, 2003