- Tony Alcantar
- Luis Sosa
- Tarik Batal
- Additional Voices
- Doron Bell
- Additional Voices
- Michael Benyaer
- Sammy Sosa
- Brent Chapman
- Additional Voices
- Suzanne Coy
- Lucrecia
- Neil Denis
- Additional Voices
- Michael Dobson
- St. Louis Cardinals' Announcer
- Paul Dobson
- Omar Minaya / Domingo / Chicago Cubs' Assistant / Bill Clinton (voice)
- Philip Maurice Hayes
- Mark McGwire / Politician (voice)
- Saffron Henderson
- Raquel Sosa / Magalise Sosa (voice)
- Rice Honeywell
- Additional Voices
- Aaron Joseph
- Luis Sosa as a Child
- David Kaye
- Male Reporter / Chicago Cubs' Play-by-Play Announcer / Second Reporter (voice)
- Scott McNeil
- Play-by-play Announcer / Texas Rangers' Catcher / Chicago Cubs' Player #1 / Chicago Cubs' Player #3 / Fan / Reporter #1 / Reporter #2 (voice)
- Richard Newman
- Chicago White Sox's Manager / Award Host (voice)
- Zahf Paroo
- Additional Voices
- Tonjha Richardson
- Marta
- Alvin Sanders
- Coach Billy Williams / Minor League Umpire / Chicago White Sox's Play-by-play Announcer (voice)
- Brad Swaile
- Sammy Sosa as a teenager / Child Fan #2 (voice)
- Francisco Trujillo Avalos-Davidson
- Juan Bautista Montero
- Cathy Weseluck
- The Sosa Family's Sister / Female Reporter / Third Reporter / Keysha Sosa (voice)
- Dale Wilson
- Jim Riggleman / Jeff Pentland / Sports Anchor / First Reporter (voice)
- Bill Clinton
- Self
- Sammy Sosa
- Self
