- Ellis Henican
- Â Derek 'Stormy' Waters 42 episodes, 2000-2005
- Brett Butler
- Â Dr. Quentin Q. Quinn / ... 42 episodes, 2000-2005
- Bill Lobley
- Â Jodene Sparks / ... 41 episodes, 2000-2005
- Kate Miller
- Â Debbie DuPree 41 episodes, 2000-2005
- Erik Estrada
- Â Marco Rodrigo Diaz de Vivar Gabriel Garcia Marquez / ... 35 episodes, 2000-2005
- Harry Goz
- Â Captain Hazel 'Hank' Murphy 31 episodes, 2000-2005
- Adam Reed
- Â Virjay / ... 21 episodes, 2000-2004
- Chris Ward
- Â Hesh Hipplewhite / ... 19 episodes, 2000-2005
- Matt Thompson
- Â Sharko / ... 13 episodes, 2000-2005
- Michael Goz
- Â Captain Bellerophon 'Tornado' Shanks / ... 10 episodes, 2004-2005
- Christian Danley
- Â Self / ... 9 episodes, 2002-2005
- Angela Elayne Gibbs
- Â Black Debbie / ... 8 episodes, 2001-2005
- John J. Miller
- Â Master Loo / ... 7 episodes, 2000-2003
- Dave Willis
- Â Meatwad / ... 5 episodes, 2001-2003
- Ed Mundy
- Â Phil / ... 5 episodes, 2002-2005
- Molly Charette
- Â Orphan 3 episodes, 2000
- Dave Roberts
- Â General #1 3 episodes, 2002-2003
- Tiffany Morgan
- Â Access Tonight Reporter / ... 3 episodes, 2002
- Dana Snyder
- Â Master Shake 1 episode, 2001
- George Lowe
- Â Dick / ... 1 episode, 2001
- Christopher Reid
- Â Self 2 episodes, 2002-2003
- Jeremy Schwartz
- Â Eskimo / ... 2 episodes, 2005
- Brian Bloom
- Â Beck Bristow 1 episode, 2003
- Don Kennedy
- Â Admiral 1 episode, 2003
- Lia Redding
- Â Orphan 1 episode, 2001
- Christopher Martin
- Â Self 1 episode, 2002
- Simon Yin
- Â Asian Men 1 episode, 2003
- Barry Mills
- Â Mickey 1 episode, 2003
- Matt Chapman
- Â Larry Palaroncini 1 episode, 2004
- Marsha Crenshaw
- Â Joy 1 episode, 2004
- Angus McLynn
- Â Additional voices 1 episode, 2004
- Finbar McLynn
- Â Additional voices 1 episode, 2004
- Carey Means
- Â Frylock (uncredited) 1 episode, 2001
- Andy Merrill
- Â Brak (uncredited) 1 episode, 2001
- C. Martin Croker
- Â Zorak (uncredited) 1 episode, 2001