- Paul Muni
- Tony
- Ann Dvorak
- Cesca
- Karen Morley
- Poppy
- Osgood Perkins
- Lovo
- C. Henry Gordon
- Guarino
- George Raft
- Rinaldo
- Vince Barnett
- Angelo
- Boris Karloff
- Gaffney
- Purnell Pratt
- Publisher
- Tully Marshall
- Managing Editor
- Inez Palange
- Tony's Mother
- Edwin Maxwell
- Detective Chief
- Henry Armetta
- Pietro - Barber
- Gus Arnheim
- Orchestra Leader
- Eugenie Besserer
- Citizens Committee Member
- Maurice Black
- Jim - Headwaiter
- William A. Boardway
- Nightclub Patron
- William Burress
- Judge (alternate ending)
- James Conaty
- Nightclub Patron
- Gino Corrado
- Waiter at Columbia Cafe
- Virginia Dabney
- Mabel
- William B. Davidson
- Citizens Committee Member
- James Durkin
- Newspaper Man
- Bill Elliott
- Man Outside Theatre
- Eddie Fetherston
- Reporter
- Paul Fix
- Hood with Gaffney
- Francis Ford
- Prison Guard (alternate ending)
- Dick Gordon
- Nightclub Patron
- Gus Arnheim and His Orchestra
- Paradise Club Orchestra
- Jean Harlow
- Blonde at Paradise Club
- Howard Hawks
- Man on Bed
- Brandon Hurst
- Citizens Committee Member
- Sydney Jarvis
- Bartender
- John Kelly
- One of Costillo's Hoods
- John Lee Mahin
- MacArthur from the Journal
- Hank Mann
- Stag Party Janitor
- Frank McLure
- Nightclub Patron
- Frank Mills
- Hood
- Jocko the Monkey
- Scarfaces Monkey
- George Nardelli
- Nightclub Patron
- William H. O'Brien
- Waiter
- Dennis O'Keefe
- Night Club Patron
- Jack Perry
- One of Costillo's Hoods
- Pedro Regas
- Tony - Bodyguard
- Warner Richmond
- Cesca's Dance Partner
- Constantine Romanoff
- Henchman
- Ronald R. Rondell
- Hood
- Marion Sayers
- Girl
- Bert Starkey
- Epstein - Lawyer
- Charles Sullivan
- One of Costillo's Hoods
- Harry Tenbrook
- One of Costillo's Hoods
- Helen C. Thompson
- Sadie Thompson
- Nick Thompson
- One of Costillo's Hoods
- Ellinor Vanderveer
- Theatregoer
- Harry J. Vejar
- Big Louis Costillo
- Sailor Vincent
- One of Costillo's Hoods
- Douglas Walton
- Cesca's Boyfriend
- Stanhope Wheatcroft
- Nightclub Patron
