- Dana Carvey
- President George H.W. Bush, H. Ross Perot, and others
- Phil Hartman
- Bill Clinton, Admiral James Stockdale and others
- Dan Aykroyd
- President Richard M. Nixon, President Jimmy Carter
- Richard Benjamin
- Ros Denton
- A. Whitney Brown
- White House Staffer
- Gary Busey
- Billy Carter
- Chevy Chase
- President Gerald Ford
- Ellen Cleghorne
- Anita Hill
- Nora Dunn
- Various Characters
- Kirsten Dunst
- George Bush's Granddaughter
- Chris Farley
- Sen. Howell Heflin, Various
- Michael J. Fox
- Dan Quayle
- Al Franken
- Sen. Paul Simon
- Tom Hanks
- Peter Jennings
- Buck Henry
- John Dean
- Jan Hooks
- Various Characters
- Eric Idle
- David Frost
- Jon Lovitz
- Gov. Michael Dukakis
- Tim Meadows
- Judge Clarence Thomas
- Dennis Miller
- White House Aide
- Garrett Morris
- Violet Crawford
- Bill Murray
- Matt
- Kevin Nealon
- Sam Donaldson, Various Characters
- Ron Nessen
- Self
- Laraine Newman
- Rosalyn Carter
- Randy Quaid
- President Ronald Reagan
- Gilda Radner
- Baba Wawa, Miss Lillian Carter
- Ron Reagan
- Self
- Chris Rock
- Long Dong Silver
- Arnold Schwarzenegger
- Self
- David Spade
- Ross Perot
- Julia Sweeney
- Jane Pauley
- Terry Sweeney
- Nancy Reagan
