- Fred Armisen
- Barack Obama / Various (archive footage)
- Dan Aykroyd
- Jimmy Carter
- Dana Carvey
- Ross Perot / George Bush (archive footage)
- Chevy Chase
- Gerald Ford
- Hillary Clinton
- Self
- Jane Curtin
- Liz Montgomery
- Amber Lee Ettinger
- Obama Girl
- Jimmy Fallon
- Self
- Will Ferrell
- George W. Bush
- Tina Fey
- Sarah Palin
- Will Forte
- John Edwards
- Rudy Giuliani
- Self
- Al Gore
- Self
- Tipper Gore
- Self
- Bill Hader
- Kevin Quigley
- Darrell Hammond
- John McCain / Chris Matthews / Fred Thompson (archive footage)
- Phil Hartman
- Ronald Reagan
- Jan Hooks
- Diane Sawyer
- Mike Huckabee
- Self
- Jon Lovitz
- Michael Dukakis
- John McCain
- Self
- Seth Meyers
- Weekend Update Anchor
- Lorne Michaels
- Self
- Dennis Miller
- White House Aide
- Tracy Morgan
- Self
- Bobby Moynihan
- Anthony Cipelli
- Bill Murray
- William Murray / Walter Cronkite (archive footage)
- Barack Obama
- Self
- Sarah Palin
- Self
- Chris Parnell
- Tom Brokaw / Various (archive footage)
- Amy Poehler
- Hillary Clinton / Katie Couric / Various (archive footage)
- Queen Latifah
- Gwen Ifill
- Andy Samberg
- Various
- Jason Sudeikis
- Joe Biden / Various (archive footage)
- Kenan Thompson
- Dalton Cheeks
- Kristen Wiig
- Nancy Pelosi / Various (archive footage)
- Casey Wilson
- Elizabeth Wheeler
