- John DeMita
- Â Alexander / ... 14 episodes, 1999-2000
- Michael Sorich
- Â Bessus / ... 14 episodes, 1999-2000
- Mary Elizabeth McGlynn
- Â Cassandra 13 episodes, 1999
- Beau Billingslea
- Â Antigonos 13 episodes, 1999
- Wendee Lee
- Â Euclid / ... 10 episodes, 1999-2000
- Lex Lang
- Â Parmenion / ... 9 episodes, 1999
- Skip Stellrecht
- Â Dinocrates / ... 9 episodes, 1999
- Bob Papenbrook
- Â Plato / ... 9 episodes, 1999
- Alan Shearman
- Â Aristotle 9 episodes, 1999
- Ralph Votrian
- Â Narration 9 episodes, 1999
- Tom Fahn
- Â Ptolemy 9 episodes, 1999
- Kirk Thornton
- Â Demosthenes 8 episodes, 1999
- Cindy Robinson
- Â Roxanne 8 episodes, 1999
- Neil Kaplan
- Â Ibn 8 episodes, 1999
- Terrence Stone
- Â Additional Voices 8 episodes, 1999
- Tony Pope
- Â Pythagoras 8 episodes, 1999
- Andrew Philpot
- Â Alexender / ... 5 episodes, 1999-2000
- Alex Fernandez
- Â Philotas / ... 5 episodes, 1999-2000
- Carlos Ferro
- Â Darius / ... 5 episodes, 1999-2000
- John DiMaggio
- Â Philip II / ... 5 episodes, 1999-2000
- John Rafter Lee
- Â Aristotle 5 episodes, 1999-2000
- Julia Fletcher
- Â Olympias / ... 5 episodes, 1999-2000
- Matt McKenzie
- Â Ptolemy / ... 5 episodes, 1999-2000
- Michael Scott Ryan
- Â Parmenion / ... 5 episodes, 1999-2000
- Jimmy Silver
- Â Narration 4 episodes, 1999
- Roger Rose
- Â Diogenes 3 episodes, 1999
- Denise Poirier
- Â Cassandra 1 episode, 2000
- Dwight Schultz
- Â Additional Voices / ... 1 episode, 2000
- Tara Strong
- Â Roxanne 1 episode, 2000
- Barbara Goodson
- Â Additional Voices 1 episode, 2000
- David Rasner
- Â Additional Voices 1 episode, 2000
- Debi Derryberry
- Â Additional Voices 1 episode, 2000
- Jennifer Darling
- Â Additional Voices 1 episode, 2000
- John Hostetter
- Â Additional Voices 1 episode, 2000
- Kerrigan Mahan
- Â Additional Voices 1 episode, 2000
- Matt K. Miller
- Â Additional Voices 1 episode, 2000
- Mona Marshall
- Â Additional Voices 1 episode, 2000
- Sherry Lynn
- Â Additional Voices 1 episode, 2000
- Steve Blum
- Â Additional Voices 1 episode, 2000
- Scott Menville
- Â Additional Voices 1 episode, 2000
- Nicholas Tse
- Â (Cantonese version) unknown episodes
- Atsuko Tanaka
- Â Cassandra unknown episodes
- Kôichi Yamadera
- Â Darius unknown episodes
- Lee Jung-hyun
- Â Chimera unknown episodes
- John Wesley
- Â Aristotle, Antipater unknown episodes
- Hôchû Ôtsuka
- Â Claytos unknown episodes
- Toshihiko Seki
- Â Alexander the Great unknown episodes
- Jordan Chan
- Â King Phillip (Cantonese version) unknown episodes
- Shûichi Ikeda
- Â Ptolemy unknown episodes
- Elaine Lui
- Â Snake Goddess (Cantonese version) unknown episodes
- Takeshi Aono
- Â Attalos unknown episodes
- Yûko Minaguchi
- Â Roxanne unknown episodes
- Shinji Ogawa
- Â Ivn charia / ... unknown episodes
- Tetsurô Sagawa
- Â Plato unknown episodes
- Angela Ying-Ying Tong
- Â Chimera (Cantonese version) unknown episodes
- Tamio Ôki
- Â Gen. Antipater unknown episodes
- Yoshisada Sakaguchi
- Â King phillip unknown episodes
- Sonny Chang
- Â Alexander the Great (Cantonese version) unknown episodes
- Nachi Nozawa
- Â Aristotle unknown episodes
- Lee Dae-kun
- Â King Phillip unknown episodes
- Kôsuke Meguro
- Â Philotas unknown episodes
- Tadashi Nakamura
- Â Gen. Parmenion unknown episodes
- Loren Manda
- Â Diogenes unknown episodes
- Kazuo Kumakura
- Â Diogenes unknown episodes
- Junko Mashina
- Â Olympias unknown episodes
- Boo Su Han
- Â Alexander the Great unknown episodes
- Trinity Stiles
- Â Chimera (English version) unknown episodes
