- J.G. Quintel
- Â Mordecai / ... 244 episodes, 2010-2017
- William Salyers
- Â Rigby / ... 244 episodes, 2010-2017
- Sam Marin
- Â Benson / ... 219 episodes, 2010-2017
- Mark Hamill
- Â Skips / ... 162 episodes, 2010-2017
- Roger Craig Smith
- Â Thomas / ... 122 episodes, 2011-2017
- Minty Lewis
- Â Eileen / ... 78 episodes, 2011-2017
- Janie Haddad Tompkins
- Â Margaret / ... 63 episodes, 2010-2017
- Courtenay Taylor
- Â Starla / ... 44 episodes, 2011-2016
- Steve Blum
- Â Carter / ... 31 episodes, 2010-2017
- Fred Tatasciore
- Â Muscle Dad / ... 28 episodes, 2012-2017
- John Cygan
- Â Main Bear / ... 27 episodes, 2012-2016
- Ali Hillis
- Â Pam / ... 25 episodes, 2013-2016
- Linda Cardellini
- Â C.J. / ... 24 episodes, 2012-2015
- Jeff Bennett
- Â Knight / ... 23 episodes, 2010-2016
- David Kaye
- Â Reginald / ... 21 episodes, 2010-2017
- Robin Atkin Downes
- Â Gary / ... 20 episodes, 2010-2017
- David Ogden Stiers
- Â Mr. Maellard 18 episodes, 2011-2016
- Troy Baker
- Â Dr. Langer / ... 14 episodes, 2011-2016
- Julian Holloway
- Â Death / ... 13 episodes, 2011-2017
- Matthew Mercer
- Â Chance Sureshot / ... 12 episodes, 2016-2017
- Vanessa Marshall
- Â Toothpick Sally / ... 12 episodes, 2015-2017
- D.C. Douglas
- Â Colonel Rawls / ... 10 episodes, 2016-2017
- Richard McGonagle
- Â Reel to Reel / ... 8 episodes, 2011-2017
- Robert Englund
- Â Anti-Pops / ... 8 episodes, 2011-2017
- Armin Shimerman
- Â Dr. Henry / ... 8 episodes, 2012-2016
- Jennifer Hale
- Â Denise / ... 7 episodes, 2010-2015
- Rich Sommer
- Â Del Hanlon / ... 7 episodes, 2015-2017
- Kurtwood Smith
- Â Gene / ... 7 episodes, 2012-2016
- Ben Diskin
- Â Aiden / ... 6 episodes, 2015-2016
- Paul F. Tompkins
- Â Cricket #5 / ... 5 episodes, 2010-2012
- Grey Griffin
- Â Culette / ... 5 episodes, 2014-2015
- David Koechner
- Â Principal Dean / ... 5 episodes, 2015-2016
- Feodor Chin
- Â Earl / ... 4 episodes, 2016-2017
- Andres Salaff
- Â Dog / ... 4 episodes, 2013-2015
- Adam Pally
- Â Party Horse / ... 4 episodes, 2015-2017
- Travis Willingham
- Â American Official / ... 4 episodes, 2014-2015
- Eddie Pepitone
- Â Rigby's Dad / ... 4 episodes, 2015-2016
- Sean Szeles
- Â Angel / ... 3 episodes, 2010-2017
- Julian Rebolledo
- Â Don 3 episodes, 2010-2016
- James Hong
- Â Keith / ... 3 episodes, 2012-2016
- Andy Daly
- Â Darryl / ... 3 episodes, 2012
- Andrew Kishino
- Â Doug McFarlane / ... 3 episodes, 2013
- Gillian Jacobs
- Â Blu-Ray / ... 3 episodes, 2017
- Trevor Devall
- Â HD DVD / ... 3 episodes, 2017
- Phil LaMarr
- Â Body Bad Guy 2 / ... 3 episodes, 2013-2015
- Laura Bailey
- Â Girl #2 / ... 3 episodes, 2014-2015
- Jason Mantzoukas
- Â Sad Sax Guy / ... 3 episodes, 2015
- Roger Jackson
- Â Baby #1 / ... 2 episodes, 2010-2011
- Michael Dorn
- Â Thomas 2 episodes, 2012-2014
- Tim Curry
- Â Hot Dog Leader / ... 2 episodes, 2010
- S. Scott Bullock
- Â Coffee Bean / ... 2 episodes, 2010
- April Stewart
- Â Susan / ... 2 episodes, 2011
- Carl Weathers
- Â Basketball King / ... 2 episodes, 2011-2013
- Tom Lister Jr.
- Â Bobby 1 episode, 2011
- Matt Price
- Â Quips 2 episodes, 2013-2014
- Brad Culver
- Â Jimmy the Taco Truck Vendor / ... 2 episodes, 2011-2012
- Rich Fulcher
- Â Answering Machine / ... 2 episodes, 2012-2014
- Yuri Lowenthal
- Â Adam / ... 2 episodes, 2011-2013
- Kyle Kinane
- Â Doorman / ... 2 episodes, 2012-2013
- Dee Bradley Baker
- Â Eggum-Kranus / ... 2 episodes, 2016-2017
- Keith David
- Â Streaming 2 episodes, 2017
- Dawnn Lewis
- Â Duck Lady / ... 2 episodes, 2012-2013
- Wayne Knight
- Â God of Street Performing / ... 2 episodes, 2013
- Katey Sagal
- Â Mordecai's Mom / ... 2 episodes, 2014-2015
- Zosia Mamet
- Â Celia / ... 2 episodes, 2014-2015
- Danny Cooksey
- Â Officer Glenn / ... 2 episodes, 2014-2015
- Matthew Yang King
- Â Merle / ... 2 episodes, 2014
- Chelsea Kane
- Â Bathing Suit Party Horse / ... 2 episodes, 2015-2016
- Steve Agee
- Â Corny / ... 2 episodes, 2015-2016
- James Adomian
- Â Harry / ... 2 episodes, 2015-2016
- Jonathan Oldham
- Â Delivery Guy / ... 2 episodes, 2015
- Kate Higgins
- Â Computer / ... 2 episodes, 2016
- Mitzi McCall
- Â Librarian 1 episode, 2011
- Alan Sklar
- Â Father Time 1 episode, 2011
- Tyler the Creator
- Â Big Trouble / ... 1 episode, 2011
- Natasha Leggero
- Â Girl in Line / ... 1 episode, 2012
- Elle Newlands
- Â Death's Wife 1 episode, 2012
- Scott MacDonald
- Â Major Williams 1 episode, 2010
- Eamon Pirruccello
- Â Kid #1 1 episode, 2010
- Nolan North
- Â Dude / ... 1 episode, 2011
- Sunil Malhotra
- Â Teacher 1 episode, 2011
- Roger Rose
- Â Informercial VO 1 episode, 2011
- MC Lyte
- Â Demel-ishun 1 episode, 2011
- Terry Crews
- Â Broc Stettman 1 episode, 2013
- B.J. Ward
- Â Dr. Asinovskovich / ... 1 episode, 2010
- Greyden Massey
- Â Kid #2 1 episode, 2010
- Donald Glover
- Â Alpha Dog 1 episode, 2011
- Josh Keaton
- Â Auto T 1 episode, 2013
- David Sobolov
- Â Dale 1 episode, 2013
- Lee Reherman
- Â Forearmageddon / ... 1 episode, 2011
- LeToya Luckett
- Â Jennifer 1 episode, 2013
- James Sie
- Â Jimmy 1 episode, 2010
- Chord Overstreet
- Â Dusty B 1 episode, 2013
- Alastair Duncan
- Â Mordecai's Dad / ... 1 episode, 2013
- Christine Baranski
- Â Guardian 1 episode, 2017
- Kari Wahlgren
- Â Movie Actress 1 episode, 2011
- Tara Platt
- Â Woman 1 episode, 2011
- Thomas Haden Church
- Â Quillgin 1 episode, 2012
- Edward Asner
- Â Santa Claus 1 episode, 2012
- Seymour Cassel
- Â Tony 1 episode, 2012
- Michael Ann Young
- Â Donut Girl 1 episode, 2012
- Toby Jones
- Â Cart 1 episode, 2012
- Trent Baker
- Â Food / ... 1 episode, 2012
- Bobcat Goldthwait
- Â Johnny Crasher 1 episode, 2013
- Jaleel White
- Â Cool Shade / ... 1 episode, 2013
- Lex Lang
- Â Barry / ... 1 episode, 2013
- Richard Doyle
- Â Old Guy 1 1 episode, 2013
- Amber Hood
- Â Huggstable #1 / ... 1 episode, 2013
- Liam O'Brien
- Â Tango 1 episode, 2014
- Christopher McDonald
- Â Carl Putter 1 episode, 2014
- Debra Wilson
- Â Blonde Girl / ... 1 episode, 2014
- Ed Begley Jr.
- Â William 1 episode, 2014
- Steven Weber
- Â Jumpin' Jim 1 episode, 2014
- Edie McClurg
- Â Muscle Man's Mom 1 episode, 2014
- Tim Russ
- Â Helicopter Pilot / ... 1 episode, 2014
- Mark Deklin
- Â Corporal 1 episode, 2014
- Chris Cox
- Â Benny Harris 1 episode, 2014
- Rhomeyn Johnson
- Â General 1 episode, 2014
- Amy Sedaris
- Â Jayla / ... 1 episode, 2015
- Awkwafina
- Â Apple / ... 1 episode, 2015
- Joel McHale
- Â DVD 1 episode, 2015
- Kevin Michael Richardson
- Â Happy Birthday 1 episode, 2015
- George Takei
- Â Daisuke 1 episode, 2015
- Paul Scheer
- Â Cat Masterson 1 episode, 2015
- Dean Cameron
- Â Suit 1 episode, 2015
- Gwendoline Yeo
- Â Girl 2 / ... 1 episode, 2015
- Jon Daly
- Â Oren / ... 1 episode, 2015
- Elizabeth Pan
- Â Girl 1 / ... 1 episode, 2015
- Rina Hoshino
- Â Singer 1 episode, 2015
- John Wusah
- Â Kobe 1 episode, 2015
- Jimmy Tang
- Â Announcer / ... 1 episode, 2015
- Jemaine Clement
- Â Ziggy 1 episode, 2016
- Wallace Shawn
- Â The Evil Brain 1 episode, 2016
- Kate Micucci
- Â Roxy 1 episode, 2016
- Steve Little
- Â Spacey McSpaceTree 1 episode, 2016
- John Gemberling
- Â Steve Mikulski 1 episode, 2016
- Neil deGrasse Tyson
- Â Self 1 episode, 2016
- Yvette Nicole Brown
- Â The Seer 1 episode, 2017
- Kiri S. Stevens
- Â Dude 1 episode, 2017