- Lee Pace
- Â Ned 22 episodes, 2007-2009
- Anna Friel
- Â Charlotte 'Chuck' Charles 22 episodes, 2007-2009
- Chi McBride
- Â Emerson Cod 22 episodes, 2007-2009
- Jim Dale
- Â Narrator 22 episodes, 2007-2009
- Ellen Greene
- Â Vivian Charles 22 episodes, 2007-2009
- Swoosie Kurtz
- Â Lily Charles 22 episodes, 2007-2009
- Kristin Chenoweth
- Â Olive Snook 22 episodes, 2007-2009
- Field Cate
- Â Young Ned 22 episodes, 2007-2009
- Sy Richardson
- Â Coroner 11 episodes, 2007-2009
- Samantha Hanratty
- Â Young Chuck 5 episodes, 2007-2009
- Stephen Root
- Â Dwight Dixon 5 episodes, 2008
- Leyna Nguyen
- Â News Anchor / ... 5 episodes, 2007-2008
- Diana Scarwid
- Â Mother Superior 4 episodes, 2008-2009
- Tina Gloss
- Â Ned's Mother 4 episodes, 2007-2008
- Nicholas Khayyat
- Â Eugene Mulchandani 4 episodes, 2007-2008
- Jon Eric Price
- Â Ned's Father 4 episodes, 2007-2008
- David Arquette
- Â Randy Mann 3 episodes, 2008-2009
- Christine Adams
- Â Simone Hundin 3 episodes, 2007-2009
- Victor Z. Isaac
- Â Delivery Boy 3 episodes, 2007
- Paul Reubens
- Â Oscar Vibenius 2 episodes, 2007
- Josh Randall
- Â Charles Charles 2 episodes, 2008
- Raúl Esparza
- Â Alfredo Aldarisio 2 episodes, 2007
- Terry Anzur
- Â Anchorwoman / ... 2 episodes, 2007
- Brad Grunberg
- Â Funeral Director / ... 2 episodes, 2007
- Ed Brigadier
- Â Minister 2 episodes, 2007
- Alex Miller
- Â Maurice 2 episodes, 2008
- Graham Miller
- Â Ralston 2 episodes, 2008
- Wesley Harris
- Â Science Teacher 2 episodes, 2007
- Diana Costa
- Â Olive's Mom 2 episodes, 2008-2009
- Daeg Faerch
- Â Ingmar Todd 2 episodes, 2008
- Marc Raducci
- Â Olive's Dad 2 episodes, 2008-2009
- Steven Wash Jr.
- Â Young Emerson 2 episodes, 2008-2009
- Molly Shannon
- Â Dilly Balsam 1 episode, 2007
- Patrick Fabian
- Â Mark Chase 1 episode, 2007
- Dash Mihok
- Â Lemuel 'Lefty Lem' Weinger 1 episode, 2007
- Patrick Breen
- Â Leo Gaswint 1 episode, 2007
- Carlos Alazraqui
- Â Gordon McSmalls 1 episode, 2007
- Riki Lindhome
- Â Jeanine 1 episode, 2007
- Jayma Mays
- Â Elsa / ... 1 episode, 2007
- Mark Harelik
- Â Ramsfeld Snuppy 1 episode, 2007
- Barbara Barrie
- Â Mamma Jacobs 1 episode, 2007
- Grant Shaud
- Â Steve Kaiser 1 episode, 2007
- Rachael Harris
- Â Georgeann Heaps 1 episode, 2008
- Missi Pyle
- Â Betty Bee 1 episode, 2008
- Fred Willard
- Â The Great Herrmann 1 episode, 2008
- Mo Collins
- Â Sister Larue 1 episode, 2008
- Orlando Jones
- Â Magnus Olsdatter 1 episode, 2008
- Shelley Berman
- Â Gustav Hofer 1 episode, 2008
- Wendie Malick
- Â Coral Ramora 1 episode, 2009
- Richard Benjamin
- Â Jerry Holmes 1 episode, 2009
- Julia Campbell
- Â Emma Newsome 1 episode, 2007
- Eddie Shin
- Â Wilfred Woodruff 1 episode, 2007
- Jonathan Mangum
- Â Bernard Slaybeck 1 episode, 2007
- Tim Conlon
- Â Chas Spielman 1 episode, 2007
- E.J. Callahan
- Â Jackson Lucas 1 episode, 2007
- Lydia Look
- Â Heather Hundin 1 episode, 2007
- Ralph P. Martin
- Â Pinky McCoy 1 episode, 2007
- Michael Cornacchia
- Â Burly Bruce Carter 1 episode, 2007
- Ivana Milicevic
- Â Hedda Lillihammer 1 episode, 2008
- Graham McTavish
- Â Hansel Von Getz 1 episode, 2008
- Tim Bagley
- Â Colonel Likkin 1 episode, 2008
- French Stewart
- Â Woolsey Nicholls 1 episode, 2008
- Lee Arenberg
- Â Arnaud Bailey 1 episode, 2008
- Debra Mooney
- Â Calista Cod 1 episode, 2008
- Perry Anzilotti
- Â Augustus Papen 1 episode, 2008
- Danny Comden
- Â Rob Wright 1 episode, 2008
- Robert Picardo
- Â Detective Puget 1 episode, 2009
- George Segal
- Â Roy 'Buster' Bustamante 1 episode, 2009
- Nora Dunn
- Â Blanche Ramora 1 episode, 2009
- Jessica Lundy
- Â Hillary Hundin 1 episode, 2007
- Christopher Neiman
- Â Lucas Shoemaker 1 episode, 2007
- Omar Avila
- Â Manuel 1 episode, 2007
- Sarah Jayne Jensen
- Â Anita Gray 1 episode, 2007
- Patrick Fischler
- Â The Waffle Nazi 1 episode, 2008
- Jennifer Elise Cox
- Â Elise Hofer 1 episode, 2008
- Alexander Gould
- Â Elliot McQuoddy 1 episode, 2008
- Paul F. Tompkins
- Â Gunther Pinker 1 episode, 2008
- Peter Cambor
- Â Dusty Fitz 1 episode, 2008
- Alexandra Barreto
- Â Veronica Villanueva 1 episode, 2008
- Michael Weaver
- Â Nils Nilsen 1 episode, 2008
- Blake Kushi
- Â Rubbie Wu 1 episode, 2008
- Wilson Cruz
- Â Sid Tango 1 episode, 2009
- Francesca P. Roberts
- Â Amelia Stingwell 1 episode, 2009
- Hamish Linklater
- Â John Joseph Jacobs 1 episode, 2007
- Joel McHale
- Â Harold Hundin 2 episodes, 2007-2008
- Steve Hytner
- Â Andrew Brown 1 episode, 2007
- Christopher Sieber
- Â Napoleon LeNez 1 episode, 2007
- Colby Paul
- Â Abner Newsome 1 episode, 2007
- Matt Braunger
- Â Rick 1 episode, 2007
- Ted Garcia
- Â Newscaster #1 1 episode, 2007
- Autumn Reeser
- Â Kentucky Fitz 1 episode, 2008
- Michael Hitchcock
- Â Father Eduardo Dedonde 1 episode, 2008
- Beth Grant
- Â Marianne Marie Beattle 1 episode, 2008
- Ethan Phillips
- Â Daniel Hill 1 episode, 2008
- Dana Davis
- Â Barb 1 episode, 2008
- Googy Gress
- Â Bryce Von Deenis 1 episode, 2008
- Andrea Lui
- Â Mei Ting 1 episode, 2008
- Gina Torres
- Â Lila Robinson 1 episode, 2009
- Willie Garson
- Â Dick Dicker 1 episode, 2009
- Michael McDonald
- Â Galveston Gus 1 episode, 2009
- Audrey Wasilewski
- Â Madeline McLean 1 episode, 2007
- Jenny Wade
- Â Hallie Hundin 1 episode, 2007
- Mike White
- Â Billy Balsam 1 episode, 2007
- Murray Gershenz
- Â Rabbi 1 episode, 2007
- Howard Mann
- Â Elderly Man 1 episode, 2007
- Vince Cefalu
- Â Bradan 1 episode, 2007
- Eric Stonestreet
- Â Leo Burns 1 episode, 2008
- David Koechner
- Â Merle McQuoddy 1 episode, 2008
- Hayes MacArthur
- Â Buddy Amicus 1 episode, 2008
- Theo Alexander
- Â Pierre 1 episode, 2008
- Samantha Bailey
- Â Young Olive 1 episode, 2008
- Jamison Yang
- Â Tam Phong 1 episode, 2008
- Fred Williamson
- Â Roland 'Rollie' Stingwell 1 episode, 2009
- Joey Slotnick
- Â Jimmy Neptune 1 episode, 2009
- Tammy Dahlstrom
- Â Woman 1 episode, 2007
- Dan Glenn
- Â Young Jackson 1 episode, 2007
- Taji Coleman
- Â Beth 1 episode, 2007
- Mary Kay Place
- Â Annabelle Vandersloop 1 episode, 2008
- Phil Abrams
- Â Dr. Eugene Halifax 1 episode, 2008
- Josh Hopkins
- Â Shane Trickle 1 episode, 2009
- Matt Winston
- Â Michael Brunt 1 episode, 2009
- Wayne Wilderson
- Â Wendell Featherstone 1 episode, 2009
- Allan Graf
- Â Angry Neighbor 1 episode, 2007
- Kristin Dos Santos
- Â 30's Woman 1 episode, 2007
- Alex Endeshaw
- Â Lab Technician 1 episode, 2007
- Tara Donato
- Â Sheila 1 episode, 2007
- Kerri Kenney
- Â Alexandria 1 episode, 2008
- Ping Wu
- Â Bao Ting 1 episode, 2008
- Mary K. DeVault
- Â Sister Maria Christina 1 episode, 2008
- Jordan Feldman
- Â Willie Gerkin 1 episode, 2008
- Amelia Borella
- Â Young Calista 1 episode, 2008
- Michael Christian Alexander
- Â Customer #1 1 episode, 2008
- Constance Zimmer
- Â Coco Juniper 1 episode, 2009
- Scott Director
- Â He Lobster 1 episode, 2009
- Pamela Kosh
- Â Curator 1 episode, 2007
- Joe Don Harris
- Â Cop 1 episode, 2007
- Ron Yuan
- Â Shrimpboy 1 episode, 2008
- Artie O'Daly
- Â Rocky Milano 1 episode, 2008
- Hugh B. Holub
- Â Judge 1 episode, 2008
- E.B. Kogan
- Â James-Andrew - Bellboy-Porter 1 episode, 2008
- Robin Gwynne
- Â Customer 1 episode, 2008
- Heather Brooker
- Â Missy Scrivner 1 episode, 2008
- Rachel Cannon
- Â Erin Embry 1 episode, 2009
- Melinda Bennett
- Â Principal Eleanor Swindle 1 episode, 2009
- Lisa M. Haskins
- Â She Lobster 1 episode, 2009
- Jeff Marlow
- Â Victor Narramore 1 episode, 2007
- Raf Mauro
- Â Old Dead Guy 1 episode, 2007
- Albert J. Wong
- Â Fambing Woo 1 episode, 2007
- Geraud Moncure
- Â Newscaster #4 1 episode, 2007
- Colton Haynes
- Â Ares Kostopolous 1 episode, 2008
- Nicole Greenwood
- Â Ms. Moss 1 episode, 2008
- Chao Li Chi
- Â Hua Jaing 1 episode, 2008
- Kristen Olson
- Â Nora McQuoddy 1 episode, 2008
- Connor Merkovich
- Â 12 Yr Maurice 1 episode, 2008
- Sam Pancake
- Â Denny Downs 1 episode, 2009
- Stephen DeCordova
- Â Specialist #1 1 episode, 2009
- Giselle Gail Gaines
- Â Young Vivian (6 yrs) 1 episode, 2009
- Karly Rothenberg
- Â Becky 1 episode, 2007
- Michael Merton
- Â Bill Richter 1 episode, 2007
- Joleen Lutz
- Â The Widow Likkin 1 episode, 2008
- Joshua LeBar
- Â Joe 1 episode, 2008
- Edward Chen
- Â Busboy 1 episode, 2008
- Loren Lazerine
- Â Jackie Johnny 1 episode, 2008
- Keenan Merkovich
- Â 12 Yr Ralston 1 episode, 2008
- Mackenzie Brooke Smith
- Â Young Lily (5 yrs) 1 episode, 2009
- Nicky Endres
- Â Tour Guide 1 episode, 2009
- Abbe Meryl Feder
- Â Tina 1 episode, 2007
- Hayley McFarland
- Â Nikki Heaps 1 episode, 2008
- Carolyn McDermott
- Â Brave-Faced Wife 1 episode, 2008
- Andy Forrest
- Â Mr. Booker 1 episode, 2009
- John Cantwell
- Â Devotee 1 episode, 2009
- Avery Stevens
- Â Young Lily (11 yrs) 1 episode, 2009
- Greg Suddeth
- Â Gravedigger #1 1 episode, 2007
- Mark Povinelli
- Â Human Cannonball / ... 1 episode, 2008
- Jason Simmons
- Â 5 Yr Maurice 1 episode, 2008
- J.R. Nutt
- Â Chris 1 episode, 2008
- Mae Hi
- Â La Di Ting 1 episode, 2008
- Sam Ingraffia
- Â Specialist #2 1 episode, 2009
- Katie Haider
- Â Synchronized Swim Double 1 episode, 2009
- David Trice
- Â Martin Miltinberger 1 episode, 2007
- Kristopher Simmons
- Â 5 Yr Ralston 1 episode, 2008
- Casey Weiant
- Â Randi Jean 1 episode, 2008
- Allen C. Liu
- Â Perry the Busboy 1 episode, 2008
- Carol Mansell
- Â Trish 1 episode, 2009
- Angela Schaub
- Â Synchronized Swim Double 1 episode, 2009
- Julie Wittner
- Â Deedee Duffield 1 episode, 2007
- Steven A. Ross
- Â Guard 1 episode, 2007
- Jolene Kim
- Â Dealer / ... 1 episode, 2008
- Ellery Sprayberry
- Â Young Olive 1 episode, 2009
- Stefan Marks
- Â Mr. Abner 1 episode, 2009
- Marita Schaub
- Â Synchronized Swim Double 1 episode, 2009
- Jeff Wolfe
- Â Shiny Shoes Killer 1 episode, 2007
- Reginald Veneziano
- Â Tony 1 episode, 2007
- Charles Shen
- Â Bodyguard #2 1 episode, 2008
- Byrne Offutt
- Â Mr. Cray 1 episode, 2009
- Jaclyn Thomas
- Â Synchronized Swim Double 1 episode, 2009
- Atticus Todd
- Â Bodyguard #1 1 episode, 2008
- Yolanda Snowball
- Â Female Teacher 1 episode, 2009
- Craig Tsuyumine
- Â Red Faced Teacher 1 episode, 2009
- Julie McKinnon
- Â Cafe patron (uncredited) 2 episodes, 2008
- Heidi Pascoe
- Â Mermaid (uncredited) 1 episode, 2007
- Arne Starr
- Â Man (uncredited) 1 episode, 2007
- Martin Beck
- Â Mourner (uncredited) 1 episode, 2007
- Gregory George Frank
- Â Businessman Visitor (uncredited) 1 episode, 2007
- George Hamilton
- Â Ned's Father (uncredited) 1 episode, 2008
- Jesse Heiman
- Â Diner Patron (uncredited) 1 episode, 2008
- Jenn Gotzon
- Â Magician's Assistant (uncredited) 1 episode, 2008
- Jackie Harris Greenberg
- Â Miss De Jong (uncredited) 1 episode, 2008
- Priscilla Leona Horne
- Â The Big Leo Burns (uncredited) 1 episode, 2008
- Maria Zambrana
- Â Passerby (uncredited) 1 episode, 2008
- Kevin Sar
- Â 1920s Poker Player (uncredited) 1 episode, 2008
- Ron Riekki
- Â Juggler (uncredited) 1 episode, 2008
- Jerald Garner
- Â Young Father (uncredited) 1 episode, 2008
- Jamie McCall
- Â Cheating Secretary (uncredited) 1 episode, 2008
- Sean R. Lake
- Â Pie Hole Patron (uncredited) 1 episode, 2008
- Naoki Sugiura
- Â Jin Quin (uncredited) 1 episode, 2008
- Peter Voytko
- Â Young Leo (uncredited) 1 episode, 2008
- Courtney Alvarez
- Â Hot Girl (uncredited) 1 episode, 2008
- Evan Shafran
- Â Crime Scene Passerby (uncredited) 1 episode, 2009
- Jonathan Grey
- Â Angry Teacher (uncredited) 1 episode, 2009
- Eve Curtis
- Â Debbie Dicker (uncredited) 1 episode, 2009
- Dustyn Lotz
- Â Devotee (uncredited) 1 episode, 2009
- Shaun Ryan
- Â Aquacade Performer (uncredited) 1 episode, 2009
- Nick Maroon
- Â Shocked Audience Member (uncredited) 1 episode, 2009