- Paul Reubens
- Pee-wee Herman
- Elizabeth Daily
- Dottie
- Mark Holton
- Francis Buxton
- Diane Salinger
- Simone
- Judd Omen
- Mickey
- Irving Hellman
- Mr. Crowtray
- Monte Landis
- Mario
- Damon Martin
- Chip
- David Glasser
- BMX Kid
- Gregory Brown
- BMX Kid
- Mark Everett
- BMX Kid
- Daryl Keith Roach
- Chuck
- Bill Cable
- Policeman #1
- Peter Looney
- Policeman #2
- Starletta DuPois
- Sgt. Hunter
- Professor Toru Tanaka
- Butler
- Ed Herlihy
- Mr. Buxton
- Ralph Seymour
- Francis' Accomplice
- Lou Cutell
- Amazing Larry
- Raymond Martino
- Gang Member
- Erica Yohn
- Madam Ruby
- Bill W. Richmond
- Highway Patrolman
- Alice Nunn
- Large Marge
- Ed Griffith
- Trucker
- Simmy Bow
- Man in Diner
- Jon Harris
- Andy
- Carmen Filpi
- Hobo Jack
- Jan Hooks
- Tina
- John Moody
- Bus Clerk
- John O'Neill
- Cowboy #1
- Alex Sharp
- Cowboy #2
- Chester Grimes
- Biker #1
- Luis Contreras
- Biker #2
- Lonnie Parkinson
- Biker #3
- Howard Hirdler
- Biker #4
- Cassandra Peterson
- Biker Mama
- Jason Hervey
- Kevin Morton
- Bob McClurg
- Studio Guard
- John Paragon
- Movie Lot Actor
- Susan Barnes
- Movie Lot Actress
- Zack Hoffman
- Director
- Lynne Marie Stewart
- Mother Superior
- George Sasaki
- Japanese Director
- Richard Brose
- Tarzan
- Drew Seward
- Kid #1
- Brett Fellman
- Kid #2
- Bob Drew
- Fireman
- John Gilgreen
- Policeman at Pet Shop
- Noreen Hennessey
- Reporter
- Phil Hartman
- Reporter
- Michael Varhol
- Photographer
- David Rothenberg
- Hobo
- Patrick Cranshaw
- Hobo
- Sunshine Parker
- Hobo
- Gilles Savard
- Pierre
- James Brolin
- James Brolin - As PeeWee
- Morgan Fairchild
- Morgan Fairchild - As 'Dottie'
- Tony Bill
- Terry Hawthorne
- Twisted Sister
- Twisted Sister
- Bill Baker
- Dancing Blonde Beach Boy / Bellboy (uncredited)
- Milton Berle
- Milton Berle
- Terry Bolo
- Biker Chick
- Faith Burton
- Alamo Tourist
- Tim Burton
- Thug in alley
- Edward Coch Jr.
- Bus Station Employee
- David Daniel
- Cowboy
- Darla
- Pink Poodle
- Juan De Villa
- Alamo Tourist
- Jaye Durkus
- Rodeo Cowboy
- Dennis Freeman
- Alamo Tourist
- Dorothy Hack
- Alamo Tourist
- Cleve Hall
- Godzilla / 'Satan's Helpers' Biker Gang Member (uncredited)
- Robert Hegyes
- Biker #5
- Clay Hodges
- Diner Patron in Leather Jacket
- James Kindelon
- Bus Passenger
- Henry Noguchi
- Godzilla Film Crew Member
- Frannie O'Carroll
- Diner Patron
- John Quijada
- Rodeo Cowboy
- Arnold Roberts
- Alamo Tourist
- Dee Snider
- Dee Snider
- John Bear Staible
- Bus Station Employee
- Richard Wakasa
- Godzilla Film Crew Member
- Bill Willens
- Biker
- Tom Willett
- Diner Patron in Blue Baseball Cap
