- Darren Dunstan
- Padre Pio
- Marc Thompson
- Antonio
- Sean Schemmel
- Prefect
- Mike Pollock
- Minister General
- Wayne Grayson
- Father Guardina
- Carmen Borgia
- Mayor
- Erica Schroeder
- Additional Voices
- Donna Coney Island
- Additional Voices
- Dan Green
- Additional Voices
- Tom Wayland
- Additional Voices
- Lisa Ortiz
- Additional Voices
- Rachel Butera
- Additional Voices
- Hilary Thomas
- Additional Voices
- Bill Rogers
- Additional Voices
- Bob Senkewicz
- Additional Voices
- Ted Lewis
- Additional Voices
- Stefano Crescentini
- Padre Pio - boy
- Sergio Di Stefano
- Padre Pio
- Massimo Lodolo
- Volto
- Gabriele Patriarca
- Padre Pio - child
- Dario Penne
- Prefetto
- Bill Timoney
- Jesus Christ (voice)
