- Doug Walker
- Â Nostalgia Critic / ... 902 episodes, 2007-2025
- Malcolm Ray
- Â Malcolm / ... 395 episodes, 2013-2025
- Tamara Chambers
- Â Tamara / ... 357 episodes, 2013-2025
- Rob Walker
- Â Rob / ... 335 episodes, 2008-2025
- James Jarosz
- Â Jim / ... 286 episodes, 2008-2025
- Ryan McGee
- Â Ryan 197 episodes, 2013-2016
- Walter Banasiak
- Â Walter / ... 143 episodes, 2015-2025
- Heather Reusz
- Â Heather / ... 140 episodes, 2016-2025
- Aiyanna Wade
- Â Aiyanna / ... 134 episodes, 2016-2025
- Brad Jones
- Â Cinema Snob / ... 52 episodes, 2010-2022
- Lewis Lovhaug
- Â Linkara / ... 41 episodes, 2009-2015
- Noah Antwiler
- Â The Spoony One / ... 39 episodes, 2009-2015
- Joe Vargas
- Â Angry Joe / ... 38 episodes, 2009-2024
- Barney Walker
- Â Dad / ... 32 episodes, 2011-2022
- Lindsay Ellis
- Â Nostalgia Chick / ... 31 episodes, 2008-2016
- Rachel Tietz
- Â Rachel / ... 33 episodes, 2013-2020
- Mathew Buck
- Â Film Brain / ... 28 episodes, 2010-2016
- Orlando Belisle
- Â Malachite / ... 28 episodes, 2010-2021
- Bennett White
- Â Bennett the Sage / ... 27 episodes, 2009-2015
- Chaplin
- Â Self / ... 27 episodes, 2018-2024
- Phelan Porteous
- Â Phelous / ... 26 episodes, 2010-2014
- Paul Schuler
- Â Paw 26 episodes, 2009-2013
- James Rolfe
- Â The Angry Video Game Nerd / ... 33 episodes, 2008-2023
- Kaylyn Saucedo
- Â MarzGurl 25 episodes, 2008-2014
- Justin Carmical
- Â JewWario / ... 23 episodes, 2010-2014
- Mickey Paradis
- Â 8-Bit Mickey 23 episodes, 2009-2014
- Bhargav Dronamraju
- Â Ma-Ti / ... 23 episodes, 2008-2012
- Brian Heinz
- Â The Last Angry Geek / ... 20 episodes, 2010-2018
- Todd Nathanson
- Â Todd in the Shadows / ... 19 episodes, 2011-2013
- Allison Pregler
- Â Obscurus Lupa 19 episodes, 2010-2014
- Benjamin Daniel
- Â Benzaie / ... 18 episodes, 2009-2012
- Kinley Mochrie
- Â Luke Mochrie 16 episodes, 2011-2012
- Thomas Hanley
- Â Handsome Tom 18 episodes, 2009-2014
- Rob Scallon
- Â Rob Scallon / ... 11 episodes, 2013-2019
- Jason Laws
- Â Meninist #2 / ... 11 episodes, 2013-2019
- Jacob Hope Chapman
- Â JesuOtaku / ... 10 episodes, 2012
- Chad Rocco
- Â C.R. 11 episodes, 2011-2013
- Jon Bailey
- Â Self / ... 10 episodes, 2015-2020
- Julien Diaz
- Â Sad Panda 9 episodes, 2012
- Antonella Inserra
- Â BFF Nella / ... 8 episodes, 2010-2013
- Elisa Hansen
- Â Dr. C. Tease / ... 9 episodes, 2011-2013
- Adonis K.J. Wright
- Â Amanda Waller / ... 8 episodes, 2015-2019
- Trevor Mueller
- Â Stanley Uris / ... 8 episodes, 2013-2022
- Fard Muhammad
- Â Fard / ... 8 episodes, 2015-2024
- Lee Davidge
- Â 3D Lee / ... 7 episodes, 2009-2010
- Jason Pullara
- Â LordKat / ... 8 episodes, 2010-2014
- Buster
- Â Self 7 episodes, 2020-2022
- Leo Thompson
- Â That Sci-fi Guy / ... 7 episodes, 2012-2019
- Elizabeth Skochil
- Â Cloak #3 7 episodes, 2011
- Dante Basco
- Â Self 8 episodes, 2014-2019
- Kyle Kallgren
- Â Oancitizen / ... 6 episodes, 2011-2013
- Kevin Baugh
- Â Fritz von Baugh / ... 6 episodes, 2010
- Jim Troken
- Â Ghost of Christmas Future / ... 6 episodes, 2011-2012
- Anthony Sardinha
- Â Nicolas Cage / ... 5 episodes, 2012-2017
- Karl Custer
- Â Uncle Yo / ... 5 episodes, 2012-2018
- Beth Elderkin
- Â Auction Customer #2 / ... 5 episodes, 2015-2016
- Andre Meadows
- Â Black Nerd 5 episodes, 2015-2018
- Brent Black
- Â Brentalfloss / ... 5 episodes, 2011-2015
- Nash Bozard
- Â Nash 5 episodes, 2011-2016
- Krissy Diggs
- Â That Chick With The Goggles / ... 5 episodes, 2008-2010
- Dayna Munday
- Â Angry Woman / ... 7 episodes, 2010-2015
- Joanna Kay
- Â Disgust / ... 5 episodes, 2013-2020
- Mike Jeavons
- Â Mike J. 4 episodes, 2010-2014
- Jori Laws
- Â Lighting Technician / ... 4 episodes, 2011-2014
- Holly Christine Brown
- Â Holly / ... 4 episodes, 2011-2012
- William DuFresne
- Â That Dude in Suede / ... 3 episodes, 2011-2012
- N. Cardena
- Â Witch Warrior 4 episodes, 2011
- Martin Billany
- Â Self - LittleKuriboh 3 episodes, 2012-2017
- The Great Luke Ski
- Â The Muthafuckin' T-Rex 3 episodes, 2013-2015
- Sandra Walker
- Â Mom / ... 4 episodes, 2013-2018
- Tony Goldmark
- Â Some Jerk with a Camera / ... 3 episodes, 2015-2017
- Kyle Hebert
- Â Self / ... 3 episodes, 2015-2018
- Corey Taylor
- Â Self / ... 3 episodes, 2017-2019
- Greg Sestero
- Â Greg Sestero / ... 4 episodes, 2013-2019
- Bryan Porter
- Â Captain Boomerang / ... 7 episodes, 2016-2017
- Jeremy Scott
- Â Jeremy 4 episodes, 2014-2019
- Chris Larios
- Â Rollo T 3 episodes, 2009-2010
- Briana Laws
- Â Chia Child / ... 3 episodes, 2011-2014
- Lindsey Z. Briggs
- Â Little Miss Gamer 3 episodes, 2009-2010
- Michael Michaud
- Â Guy Pushed Into Doorway / ... 3 episodes, 2008-2011
- Sean Fausz
- Â Hope Within Chaos 3 episodes, 2009-2010
- Tom Ruegger
- Â Self 3 episodes, 2010-2023
- Victoria Turner
- Â Bjork / ... 3 episodes, 2009-2012
- Jillian Zurawski
- Â Dolly / ... 3 episodes, 2010-2012
- Dave Myers
- Â Cat / ... 3 episodes, 2011
- Chris Stuckmann
- Â Chris Stuckmann / ... 3 episodes, 2015-2017
- Kyle Justin
- Â Guitar Guy / ... 3 episodes, 2008-2009
- Don Bluth
- Â Don Bluth 4 episodes, 2015-2022
- Eric Lewald
- Â Self 2 episodes, 2019
- Julia Lewald
- Â Self 2 episodes, 2019
- Christopher Harrison
- Â M. Night Shyamalan / ... 2 episodes, 2015-2016
- Lloyd
- Â Lloyd / ... 2 episodes, 2019-2021
- Ike
- Â Ike / ... 2 episodes, 2019-2021
- Curtis Arnott
- Â Takahata101 2 episodes, 2010-2012
- Jordan Summers
- Â Self 2 episodes, 2015
- Wendy
- Â Self / ... 2 episodes, 2019-2021
- Dom Smith
- Â Self / ... 2 episodes, 2015
- Luke Spencer
- Â Luke 2 episodes, 2015
- Chris Atkinson
- Â Chris 2 episodes, 2018-2019
- Nick Landis
- Â Lanipator 2 episodes, 2010-2012
- Tom White
- Â Heisanevilgenius 2 episodes, 2015
- Lawrence Simpson
- Â MasakoX / ... 2 episodes, 2010-2017
- Patrick Burdun
- Â Coldguy 2 episodes, 2009-2010
- Christine Thompson
- Â The Cat 2 episodes, 2009-2010
- Jerrica Benton
- Â Diamanda Hagan 2 episodes, 2012
- Tim Sampson
- Â Auction Customer #4 / ... 2 episodes, 2015-2016
- Paul Rugg
- Â Self 2 episodes, 2010-2018
- Griffin Taylor
- Â Griffin Taylor / ... 2 episodes, 2017-2019
- Cree Summer
- Â Penny / ... 3 episodes, 2016-2019
- Ryan Molina
- Â Leonardo / ... 2 episodes, 2015
- Greg Michaud
- Â Henchman / ... 2 episodes, 2012-2015
- Terrence Dellinger
- Â Gang Member / ... 2 episodes, 2012-2015
- Haley Barnes
- Â Gang Member / ... 2 episodes, 2012-2015
- Justin Barnes
- Â Gang Member / ... 2 episodes, 2012-2015
- Nikolas Freeman
- Â Y Ruler of Time 2 episodes, 2010-2012
- Michael Ellis
- Â Guy In Hotel Lobby / ... 2 episodes, 2009
- Dena Natali
- Â Dena 2 episodes, 2010-2012
- James Warren
- Â Jaffers' Roommate / ... 2 episodes, 2011-2012
- Mara Wilson
- Â Mara Wilson 2 episodes, 2012-2017
- Renee Carter
- Â Self 1 episode, 2016
- Michael Salvatori
- Â Self 1 episode, 2019
- Christopher Lloyd
- Â Self 1 episode, 2010
- Sherri Stoner
- Â Self 3 episodes, 2010-2014
- Jay Chapman
- Â Zack 2 episodes, 2011-2016
- Spike Spencer
- Â Self 1 episode, 2012
- Chris Niosi
- Â Self - Kirbopher 1 episode, 2014
- Jon Jafari
- Â JonTron 1 episode, 2014
- Adam Johnston
- Â Self 1 episode, 2016
- Alex Beltman
- Â Self 1 episode, 2016
- John P. McCann
- Â Self 1 episode, 2010
- Brandon Bledsoe
- Â Civillian / ... 1 episode, 2013
- Rob Paulsen
- Â Pinky - voice / ... 1 episode, 2014-2016
- Gideon Ray Jr.
- Â Jaden Smith 1 episode, 2014
- Nate Ruegger
- Â Self 1 episode, 2010
- Maurice LaMarche
- Â Self / ... 1 episode, 2014
- Bennett Abara
- Â Self 1 episode, 2015
- Jambareeqi
- Â Jambareeqi 1 episode, 2015
- Michael Levesque
- Â Audience Member #1 1 episode, 2016
- Sabrina Ray
- Â Malcolm's Mom 1 episode, 2014
- Taylor Chambers
- Â Fear 1 episode, 2015
- Victoria L. Tobin
- Â Voter #3 1 episode, 2015
- Cricket Leigh
- Â Self 1 episode, 2016
- Alex Fischer
- Â CrusadeFischer 1 episode, 2018
- Barrett Share
- Â Barrett 1 episode, 2019
- Jim Favia
- Â Barfly #1 1 episode, 2014
- Eric Butts
- Â Self 1 episode, 2020
- Josh Strider
- Â PhantomStrider 1 episode, 2023
- Max Powers
- Â Self 1 episode, 2015
- Rick Edwards
- Â Rick Edwards 1 episode, 2019
- Dan Rizzo
- Â That Aussie Guy 1 episode, 2009
- Robert Panico
- Â Argyle 1 episode, 2010
- Ryan Mitchelle
- Â Canoe 1 episode, 2019
- Heather McDonald
- Â Calluna 1 episode, 2015
- Joshua Langland
- Â The Horror Guru 1 episode, 2015
- Justin Fruhling
- Â Lotus Prince 1 episode, 2015
- Zachary La Voy
- Â Chicago Ghostbuster 1 episode, 2016
- Sam Fennah
- Â Sullivan Croft 1 episode, 2019
- Michael C. Parks
- Â Gang Member 1 episode, 2015
- Steve Hessler
- Â Chicago Ghostbuster 1 episode, 2016
- Raul Alcantar
- Â Audience 1 episode, 2017
- Rikki-Leigh Taffurelli
- Â Lucy Lacemaker 1 episode, 2019
- Paul DeNinno Braun
- Â Paul Braun 1 episode, 2015
- James Sanjuro
- Â Chicago Ghostbuster 1 episode, 2016
- Halie Anderson
- Â Luna 1 episode, 2019
- Jack Shen
- Â Count Jackula 2 episodes, 2015
- Ken Trayling
- Â Chicago Ghostbuster 1 episode, 2016
- Laura Luke
- Â Mrs. Snob 1 episode, 2019
- Mary Jo Chrabasz
- Â Chicago Ghostbuster 1 episode, 2016
- Angela Alice Simpson
- Â Fleischer 1 episode, 2019
- Ashley Tyler
- Â Dorothy 1 episode, 2019
- Billy Smith
- Â Dr. Gonzo 1 episode, 2009
- Mike Dodd
- Â Guy Who Just Heard There Was A Fight 1 episode, 2009
- Scott Frerichs
- Â KaiserNeko 1 episode, 2010
- Sam Goldberg
- Â Guy Lynor / ... 1 episode, 2010
- Emerson Spartz
- Â Self 1 episode, 2007
- Mike Matei
- Â Self 1 episode, 2008
- Brett Vanderbrook
- Â Captain S 1 episode, 2008
- MacInTalk
- Â Nostalgia Critic 1 episode, 2009
- Ed Glaser
- Â Man in Black #1 1 episode, 2012
- Sarah Gobble
- Â Mrs. Crabtree 1 episode, 2012
- Eric Rodriguez
- Â ERod 1 episode, 2012
- Jake Norvell
- Â R.O.B. the Robot 1 episode, 2012
- Daren Jackson
- Â Rap Critic 1 episode, 2012
- Brian Lewis
- Â Travis Crabtree 1 episode, 2012
- Mat Williams
- Â Welshy 1 episode, 2012
- John Aprigliano
- Â Smarty 1 episode, 2012
- Elliot Law
- Â MegaGWolf 1 episode, 2012
- Omar Ahmed
- Â Yomarz 1 episode, 2015
- Gunnar Kaasen
- Â Self 1 episode, 2017
- Leonhard Seppala
- Â Self - Musher 1 episode, 2017
- Togo
- Â Self 1 episode, 2017
- Lucas De Giorgi
- Â TheAmazingLucas 1 episode, 2018
- Duane Joseph Olson
- Â Fontaine 1 episode, 2019
- Gilbert Gottfried
- Â The Ever-Dramatic Theatre Guy 2 episodes, 2020-2022
- Katy O'Melia
- Â Katy 1 episode, 2020
- David Stern
- Â Self 1 episode, 2021
- Philo Barnhart
- Â Self 1 episode, 2022
- Antonio Piluso
- Â Self 1 episode, 2022
- Cyriak Harris
- Â Surreal Character in the Opening Sequence (uncredited) 1 episode, 2009
- Claire Bishop
- Â Harley Quinn (uncredited) 1 episode, 2009
- Jerrid Foiles
- Â Director (uncredited) 1 episode, 2010
- Douglas Castrejon
- Â Fan at convention (uncredited) 1 episode, 2012
- Michael Castrejon
- Â Fan at convention (uncredited) 1 episode, 2012
- Daniel Baxter
- Â Batman / ... (uncredited) 1 episode, 2013
- David Ganssle
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Nicholas Bogroff Ganssle
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Morgan Funder
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Charlie Callahan
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Rosen Thorne
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Haley Baker Callahan
- Â Jerk's Backup Dancer (uncredited) 1 episode, 2015
- Ryan Malik
- Â Fan (uncredited) 1 episode, 2016
- Lucas Bradley
- Â Wedding Guest (uncredited) 1 episode, 2018
