- Preston Foster
- Tippecanoe 'Tip' O'Neil
- Margaret Callahan
- Amy Hutchins
- Alan Mowbray
- Paul Harding
- Ralph Morgan
- Jim Glenray - Paul's Brother in Law
- Guinn 'Big Boy' Williams
- 'Red' Cable
- Maxie Rosenbloom
- Snake
- Molly Lamont
- Nancy Harding
- John Carroll
- Gene Leland
- Florine McKinney
- Corinne
- Robert Middlemass
- Inspector Brock
- Noel Madison
- Tony Spivali - Gambler
- Maxine Jennings
- Cleo
- Harold Huber
- Maratti
- Clarence Muse
- William
- Paul Porcasi
- Luigi Turseniani - Head of the Mob
- Ward Bond
- 'John Doe' - a Gangster
- John Adair
- 'John Doe Jr.' - a Gangster
- Lucille Ball
- Departing Train Passenger
- Willie Best
- Janitor at Spivali's Bar
- Jerry Frank
- Barber
- Kenner G. Kemp
- Alerted Neighbor
- Florence Lake
- Tony's Girlfriend
- Dion Muse
- William's Son
- Hector V. Sarno
- One of Luigi's Barbers
- Nicholas Soussanin
- Harding's Butler
- Ray Turner
- Train Porter
- Foy Van Dolsen
- Servant
