- Patton Oswalt
- Â Jesse 8 episodes, 2016-2018
- Catherine Taber
- Â Jesse 8 episodes, 2016-2018
- Ashley Johnson
- Â Petra 8 episodes, 2016-2018
- Scott Porter
- Â Lukas 8 episodes, 2016-2018
- Paul Reubens
- Â Ivor 7 episodes, 2016-2018
- Martha Plimpton
- Â Olivia 6 episodes, 2016-2018
- Brian Posehn
- Â Axel 5 episodes, 2016-2018
- Fred Tatasciore
- Â Jack 5 episodes, 2017
- JB Blanc
- Â The Admin 5 episodes, 2017
- Dee Bradley Baker
- Â Reuben 4 episodes, 2018
- Dave Fennoy
- Â Gabriel the Warrior / ... 4 episodes, 2018
- April Stewart
- Â Xara 4 episodes, 2017
- Corey Feldman
- Â Magnus the Rogue / ... 3 episodes, 2018
- Grey Griffin
- Â Ellegaard the Redstone Engineer / ... 3 episodes, 2018
- Jason Topolski
- Â Disco Mickey / ... 3 episodes, 2016-2018
- Matthew Mercer
- Â Aiden / ... 3 episodes, 2018
- Yvette Nicole Brown
- Â Harper 2 episodes, 2016
- John Hodgman
- Â Soren the Architect 2 episodes, 2018
- G.K. Bowes
- Â Maya / ... 2 episodes, 2018
- Phil LaMarr
- Â Gill 2 episodes, 2018
- Billy West
- Â Narrator / ... 2 episodes, 2018
- Erin Yvette
- Â Announcer / ... 2 episodes, 2018
- Melissa Hutchison
- Â Isa 1 episode, 2018
- Jim Meskimen
- Â Milo 1 episode, 2018
- Sean Astin
- Â Reginald 1 episode, 2018
- Roger Jackson
- Â The White Pumpkin 1 episode, 2016
- Jordan Maron
- Â CaptainSparklez 1 episode, 2016
- Joseph Garrett
- Â Stampy Cat 1 episode, 2016
- Jim Cummings
- Â Hadrian 1 episode, 2016
- Daniel Middleton
- Â DanTDM 1 episode, 2016
- Kari Wahlgren
- Â Mevia 1 episode, 2016
- Elizabeth Dwyer
- Â LDShadowLady 1 episode, 2016
- Jamie Alcroft
- Â Otto 1 episode, 2016
- Stacy Hinojosa
- Â Stacy Plays 1 episode, 2016
- Owen Hill
- Â Owen 1 episode, 2018
- Ashly Burch
- Â Cassie Rose 1 episode, 2016
- Christopher Duncan
- Â Slab the Immovable 1 episode, 2016
- Adam Harrington
- Â TorqueDawg 1 episode, 2016
- Julianne Buescher
- Â Clutch / ... 1 episode, 2016
- John Sanders
- Â Facemeat 1 episode, 2016
- Ursula Taherian
- Â Nohr 1 episode, 2018
- Audrey Wasilewski
- Â Emily 1 episode, 2016
- Sam Riegel
- Â Griefer 1 episode, 2018
- Michael Gambino
- Â Calvin / ... 1 episode, 2018
- Lydia Winters
- Â Lydia 1 episode, 2018
- Gregg Berger
- Â Oxblood 1 episode, 2017
- A.J. Riebli III
- Â Death Bowl Announcer 1 episode, 2018
- Ernest Guillart
- Â Doki (uncredited) 1 episode, 2016
- Katrina Carras
- Â Maya (uncredited) 1 episode, 2018
