- Giacomo Talamini
- Solid Snake
- Philip Sacramento
- Solid Snake
- Patrizia Liccardi
- Elizabeth Laeken
- Nicola Cecconi
- Pierre Leclerc
- Lucien Dodge
- Pierre Leclerc / Harrison Bishop (voice)
- Glenn Goa
- Vitalij
- Andrea Furlan
- Vitalij
- William Martin
- Otacon
- Adam Behr
- Abraham Bishop
- Giovanni Contessotto
- Abraham Bishop
- Marco Saran
- Harrison Bishop
- Pastrengo Agent
- U.S. Soldier
- Jasmine Al
- (voice)
- Matt Alan
- (voice)
- Emanuele Bresciani
- Tupolev Pilot
- Matteo Carniato
- Lachin Villager
- Simone Compri
- Outer Heaven Trooper
- Jamal Cooper
- (voice)
- Jonathan Ealam
- Newscaster
- Francesco Ferronato
- Outer Heaven Trooper
- Gabriele Foresti
- U.S. Soldier
- Giorgio Gandin
- U.S. Soldier
- Kyle Hebert
- Control 2
- Kamo Hodaj
- Outer Heaven Trooper
- Crystal Lonnquist
- (voice)
- Nicolas Marai
- Outer Heaven Trooper
- Danielle McRae
- (voice)
- Kamran Nikhad
- (voice)
- Enrico Pasotti
- Aran
- Laura Post
- Elizabeth Laeken
- Barbara Riebolge
- Lachin Villager
- Dave Robinson
- (voice)
- Lucio Sampietro
- Newscaster
- Alessandro Schiassi
- Lachin Villager
- Ivan Sisti
- Outer Heaven Trooper
- Roberto Talamini
- Lachin Villager
- Tiziana Talamini
- Lachin Villager
- Craig Taylor
- (voice)
- Edwyn Tiong
- (voice)
- Kimlinh Tran
- (voice) (as Kimlinh P. Tran)
- Alberto Vazzola
- Lachin Villager
