- Takeshi Aono
- Col. Campbell
- Earl Boen
- Sergei Gurlukovich
- Cam Clarke
- Liquid Snake
- John Cygan
- Solidus Snake
- Barry Dennen
- Fatman
- Paul Eiding
- Col. Campbell
- Quinton Flynn
- Raiden
- Yuzuru Fujimoto
- President James Johnson
- Maura Gale
- Fortune
- Banjô Ginga
- Liquid Snake
- H. Richard Greene
- President James Johnson
- Kim Mai Guest
- Karen Hojo
- Daisuke Gôri
- Scott Dolph
- Jennifer Hale
- Emma Emmerich
- David Hayter
- Solid Snake
- Yukitoshi Hori
- The Sorrow
- Ken'yû Horiuchi
- Raiden
- Kikuko Inoue
- Rosemary
- Phil LaMarr
- Vamp / Scott Dolph (voice)
- Vanessa Marshall
- Olga Gurlukovich
- James Mathis III
- Peter Stillman
- Ryôtarô Okiayu
- Vamp
- Christopher Randolph
- Dr. Hal 'Otacon' Emmerich
- Osamu Saka
- Sergei Gurlukovitch
- Ikuya Sawaki
- Revolver Ocelot
- Kôzô Shioya
- Fatman
- Larc Spies
- Cyborg Ninja
- Hideyuki Tanaka
- Dr. Hal Otacon Emmerich
- Kyôko Terase
- Olga Gurlukovitch
- David Thomas
- The Sorrow
- Yumi Tôma
- Fortune
- Kari Wahlgren
- Rosemary
- Maria Yamamoto
- Emma Emmerich
- Takumi Yamazaki
- Cyborg Ninja
- Patric Zimmerman
- Revolver Ocelot
- Shôzô Îzuka
- Peter Stillman
- Akio Ôtsuka
- Solid Snake / Solidus Snake (voice)
