- Ken Marshall
- Â Marco Polo 8 episodes, 1982-1983
- Denholm Elliott
-  Niccolò Polo 8 episodes, 1982-1983
- Tony Vogel
- Â Matteo Polo 8 episodes, 1982-1983
- David Warner
- Â Rustichello 7 episodes, 1982-1983
- F. Murray Abraham
- Â Jacopo 6 episodes, 1982-1983
- Mario Adorf
- Â Giovanni 6 episodes, 1982-1983
- Patrick Mower
- Â Brother Damian 6 episodes, 1982-1983
- Ruocheng Ying
- Â Kublai Khan 5 episodes, 1982-1983
- Beulah Quo
- Â Empress Chabi 4 episodes, 1982-1983
- Jun'ichi Ishida
- Â Prince Chinkin 4 episodes, 1982-1983
- James Hong
- Â Phags-pa 4 episodes, 1982-1983
- Gordon Mitchell
- Â Arnolfo 4 episodes, 1982-1983
- Leonard Nimoy
- Â Achmet 3 episodes, 1983
- Bruno Zanin
- Â Giulio 3 episodes, 1982
- John Dicks
- Â Brother Philip 3 episodes, 1982-1983
- Lin Lao
- Â Bayan 3 episodes, 1983
- Ian McShane
- Â Ali Ben Yussouf 2 episodes, 1982
- Sada Thompson
- Â Aunt Flora 2 episodes, 1982
- Tony Lo Bianco
- Â Brother Nicholas 2 episodes, 1982
- Soon-Tek Oh
- Â Wang Zhu 2 episodes, 1983
- Zaibao Yang
- Â Yang Ku 2 episodes, 1983
- Shaokang Yu
- Â Caidu Khan 2 episodes, 1982-1983
- Riccardo Cucciolla
- Â Uncle Zane 2 episodes, 1982
- Erkang Zhao
- Â Nayan 2 episodes, 1983
- Hesen En
- Â Bektor Khan 2 episodes, 1982-1983
- Georgia Slowe
- Â Caterina 2 episodes, 1982
- Hal Buckley
- Â Brother William 2 episodes, 1982
- Kathryn Dowling
- Â Monica 2 episodes, 1983
- Tetsurô Tanba
- Â Saiamon 2 episodes, 1983
- Agnes Chan
- Â Mai Li 2 episodes, 1983
- Bruno Corazzari
- Â Agostino 2 episodes, 1982
- Gino Santercole
- Â Giuseppe 2 episodes, 1982
- Terry Raven
- Â Talib 2 episodes, 1983
- Zengyin Cao
- Â Governor 2 episodes, 1983
- Xiaolei Huang
- Â Chen Pao 2 episodes, 1982-1983
- Renato Miracco
- Â Bartolomeo 2 episodes, 1982
- Vernon Dobtcheff
- Â Pietro d'Abano 2 episodes, 1983
- Nanni Massa
- Â Messer Paolo 2 episodes, 1982
- Shulin Sun
- Â Argan 2 episodes, 1983
- Salvatore Puntillo
- Â Messer Andrea 2 episodes, 1982
- Renhua Na
- Â Princess Kokachin 2 episodes, 1983
- Giulio Gaslini
- Â Messer Lorenzo 2 episodes, 1982
- Maria Pia Colonnello
- Â Caterina's Nurse-Maid 2 episodes, 1982
- Ma Qiang
- Â Yeli Shue 2 episodes, 1983
- Anne Bancroft
- Â Marco's Mother 1 episode, 1982
- Burt Lancaster
- Â Teobaldo Visconti - Pope Gregory X 1 episode, 1982
- John Gielgud
- Â Doge of Venice 1 episode, 1982
- John Houseman
- Â Patriarch of Aquileia 1 episode, 1982
- Jesse Dizon
- Â Novice Lama 1 episode, 1982
- Antonella Murgia
- Â Zora 1 episode, 1982
- Marilù Tolo
- Â Donna Fiammetta 1 episode, 1982
- John Karlsen
- Â Judge 1 episode, 1983
- William Squire
- Â Inn-Keeper 1 episode, 1982
- Yang Kang
- Â Kasar 1 episode, 1982
- Andrew Keir
- Â Old Shepherd 1 episode, 1982
- Tad Horino
- Â The Immortal (English version only) 1 episode, 1983
- Jack Watson
- Â Old Sailor 1 episode, 1982
- Alexander Picolo
- Â Marco as a child 1 episode, 1982
- Donato Castellaneta
- Â Monk at Santo Sepolcro 1 episode, 1982
- Henry O
- Â Astrologer 1 episode, 1983
- Kuan Shih
- Â King of Korea 1 episode, 1983
- Shi Jen Qhuan
- Â Admiral Won 1 episode, 1983
- Rossella Como
- Â Donna Laura 1 episode, 1982
- Enzo Robutti
- Â Cardinal 1 episode, 1982
- Paul Muller
- Â Brother Anselmo 1 episode, 1982
- Renato Scarpa
- Â Brother Thomas 1 episode, 1982
- Corrado Gaipa
- Â Senator 1 episode, 1982
- Germano Moratelli
- Â Cardinal 1 episode, 1982
- Angelo Pellegrino
- Â Monk 1 episode, 1982
- Rate Furlan
- Â Senator 1 episode, 1982
- Franco Fantasia
- Â Venetian Captain 1 episode, 1982
- Francesco Filippo Fassina
- Â Papal Secretary 1 episode, 1982
- Renato D'Amore
- Â Messenger 1 episode, 1982
- Ro Marcenaro
- Â Merchant 1 episode, 1982
- Carlo Nardone
- Â Sailor 1 episode, 1982
- Lorenzo Rizzato
- Â Venetian Nobleman 1 episode, 1982
- Enzo Spitaleri
- Â Senator 1 episode, 1982
- Jim Lau
- (uncredited) 1 episode, 1983
- Jack Ong
- Â Multiple voices (uncredited) 1 episode, 1983
- Ed Meyer
- Â Ambassador (uncredited) 1 episode, 1983
- Tiffany Brissette
- (uncredited) 1 episode, 1983
- Vladek Sheybal
- Â Prosecutor (uncredited) 1 episode, 1983
