- Carole Lombard
- Jane Mason
- James Stewart
- John Horace Mason
- Charles Coburn
- Judge Joseph M. Doolittle
- Lucile Watson
- Mrs. Harriet Mason
- Eddie Quillan
- Conway
- Alma Kruger
- Sister Madeline
- Irving Bacon
- Newark Radio Operator
- Raymond Bailey
- Salt Lake City Hospital Chemist
- Bonnie Belle Barber
- John Mason Jr. - Infant
- Louise Beavers
- Lily - Cook #3
- Ward Bond
- Jim Hatton
- Donald Briggs
- Mr. Carter
- Harlan Briggs
- Judge
- Lane Chandler
- Ranger on Telephone
- Frederick Chapin
- Younger Doolittle
- Russ Clark
- Omaha Radio Operator
- Monte Collins
- Juror
- James Conaty
- Co-Worker
- Esther Dale
- Annie - Cook #1
- Harry Davenport
- Dr. Healy
- Edgar Dearing
- Mounted Policeman
- Harry Depp
- Hutch
- Robert Elliott
- Airport Operations Manager
- Fern Emmett
- Farmer's Wife
- Betty Farrington
- Hospital Cashier
- Mary Field
- Johns Hopkins technician
- Ruth Gillette
- Tipsy Blonde at New Year's Eve Party
- Russell Hopton
- Collins
- Olin Howland
- Farmer
- Arthur Hoyt
- Jury Foreman
- Victor Kilian Jr.
- Chicago Radio Operator
- Tom London
- Ranger
- Ethel Marical
- Nurse
- Edwin Maxwell
- Messerschmidt
- Tom McGuire
- Bailiff
- James McNamara
- Juror
- Carlyle Moore Jr.
- North Platte Radio Operator
- Wilhelmina Morris
- Nurse
- Jack Mulhall
- Rock Springs Radio Operator
- Robert Emmett O'Connor
- Harry - Elevator Starter
- Renee Orsell
- Hilda - Cook #2
- Garry Owen
- Denver Radio Operator
- John Picorri
- Juror
- Mickey Rentschler
- Office Boy
- Cyril Ring
- Office Worker
- Mildred Shay
- John Horace Mason's Secretary
- Ivan F. Simpson
- Simon - Judge Doolittle's Brother
- Milburn Stone
- Newark Official
- Jackie Taylor
- John Mason Jr. - One Year Old
- Nella Walker
- Dr. Langham's Nurse-Receptionist
- Ruth Weston
- Eunice Doolittle
- Marjorie Wood
- Nurse
- Harry Worth
- New York Hospital Chemist
