- Danny DeVito
- Cab Driver / Narrator (voice)
- Lucy Liu
- Leo's Mother
- Freddy Rodríguez
- Leo's Father
- Brenda Song
- Paige
- Fred Newman
- Little Spirit / Ramona / Squirrel / Pigeon (voice)
- Rachel Schier
- Dylan
- Brian Williams
- Rock Granite
- Michael Hall D'Addario
- Leo
- Sally Winters
- Girls' Mom / Knitting Lady (voice)
- Todd Cummings
- News Announcer / Dead Fish (voice)
- Danny Tamberelli
- Snowball Fight Kid / Older Brother / Policeman (voice) (as Dan Tamborelli)
- Veronica Taylor
- Younger Brother / Girl on Santa's Lap (voice) (as Kathleen McInerney)
- Ramsey Faragallah
- Hot Dog Vendor
- Les Mau
- Chinese Man
- Sharon Wilkins
- African American Mom / African American Girl (voice)
- Shawn Andrew
- Security Guard
