- Jonathan Bailey
- Â Leonardo 26 episodes, 2011-2012
- Colin Ryan
- Â Lorenzo De Medici 26 episodes, 2011-2012
- Flora Spencer-Longhurst
- Â Lisa / ... 26 episodes, 2011-2012
- Akemnji Ndifornyen
- Â Machiavelli 26 episodes, 2011-2012
- James Cuningham
- Â Verrocchio / ... 24 episodes, 2011-2012
- Alistair McGowan
- Â Piero de' Medici 13 episodes, 2011
- James Clyde
- Â Piero De Medici / ... 13 episodes, 2012
- Thembalethu Ntuli
- Â Cosimo / ... 11 episodes, 2011-2012
- Camilla Waldman
- Â Teresa De Medici / ... 10 episodes, 2011-2012
- Bart Fouche
- Â Placidi 10 episodes, 2012
- Chris Olley
- Â Caporaso 7 episodes, 2011
- Graham Hopkins
- Â The Duke 6 episodes, 2011-2012
- Roxane Hayward
- Â Angelica / ... 6 episodes, 2012
- Clayton Boyd
- Â Rocco De Medici / ... 5 episodes, 2012
- Mike Huff
- Â Valerio 4 episodes, 2011
- Anthony Bishop
- Â Placidi 4 episodes, 2011
- John Herbert
- Â Mazzini 2 episodes, 2011
- Adam Neill
- Â Donnola / ... 2 episodes, 2011-2012
- Jason Benderman
- Â Benito 2 episodes, 2012
- Pam St. Clement
- Â Mazzola 2 episodes, 2012
- Patrick Lyster
- Â Dr. Pentageli / ... 2 episodes, 2012
- Vaneshran Arumugam
- Â Scarpa 2 episodes, 2012
- Emily Child
- Â Valentina 1 episode, 2011
- James Gracie
- Â Carlo Casale 1 episode, 2011
- Stephanie Schildknecht
- Â Bandit Queen 1 episode, 2011
- Vanessa Pike
- Â Sofia 1 episode, 2011
- Kyle Grant
- Â Michelangelo 1 episode, 2011
- Michael Richard
- Â Lucio 1 episode, 2011
- Malcolm Terrey
- Â Professor Pico 1 episode, 2011
- Atandwa Kani
- Â Giovanni 1 episode, 2011
- Jay Anstey
- Â Petronella 1 episode, 2011
- Russel Savadier
- Â Eduardo 1 episode, 2011
- Alistair Prodgers
- Â Gilberto 1 episode, 2011
- Cassiel Eatock-Winnik
- Â La Contessa 1 episode, 2011
- Vanessa Cooke
- Â Mrs. Schelling 1 episode, 2011
- Mororise Papole
- Â Young Mac 1 episode, 2011
- Martin Le Maitre
- Â Rizzo 1 episode, 2011
- Craig Hawks
- Â Luca 1 episode, 2011
- Langley Kirkwood
- Â Felipe 1 episode, 2012
- Jeremy Crutchley
- Â Signor Da Vinci 1 episode, 2012
- Nicholas Pauling
- Â Alberto 1 episode, 2012
- Susan Danford
- Â Nun 1 episode, 2012
- Katie McGlynn
- Â Lucia 1 episode, 2012
- Brendan Sean Murray
- Â Salvatore 1 episode, 2012
- Rory Acton Burnell
- Â Adriano 1 episode, 2012
- Joe Vaz
- Â Gorgoni 1 episode, 2012
- Sean Higgs
- Â Costa 1 episode, 2012
- Anelisa Phewa
- Â Silvio Pirelli 1 episode, 2012
- Francesco Nassimbeni
- Â Nazario 1 episode, 2012
- Philip Gargan
- Â Marco 1 episode, 2012
- Paddy Canavan
- Â Nonna Carla 1 episode, 2012
- Justin Francis
- Â Bruno Cafarelli 1 episode, 2012
- Fred Roebuck
- Â Priest 1 episode, 2012