- Kazuya Nakayama
- Okada Izo
- Kaori Momoi
- Saya
- Ryûhei Matsuda
- His Highness
- Ryôsuke Miki
- Hanpeita
- Yûya Uchida
- Second Man
- Masumi Okada
- Chief of the Palace
- Hiroki Matsukata
- Yakuza Boss
- Masato
- Ronin
- Takeshi Kitano
- Chancellor
- Joe Cappelletti
- Hanpeita
- Mickey Curtis
- (as Mikkî Kâchisu)
- Ken'ichi Endô
- Spearman torturing the crucified Izo
- Michael Forest
- Samurai
- Jessica Gee-George
- Izo's Mother
- Kate Higgins
- Teacher
- Megan Hollingshead
- Saya
- Tsurutarô Kataoka
- Warlord
- Kirin Kiki
- Izo's Mother
- Steve Kramer
- Man with Voice Box
- Dave Mallow
- Doctor
- Michael McConnohie
- Yakuza Leader
- Hiroyuki Nagato
- Great Priest
- Mari Nakayama
- Woman in Attendance
- Liam O'Brien
- Prince
- Ken Ogata
- Swordsman
- Sam Riegel
- Izo
- Christopher Corey Smith
- Businessman
- Melodee Spevack
- Original Mother
- Doug Stone
- VIP
- Kim Strauss
- High Official
- Shun Sugata
- Monk Soldier
- Haruna Takase
- Lucky Mother
- Kirk Thornton
- Prime Minister
- Kazuki Tomokawa
- Folk Singer
- Rikiya Yasuoka
- Lender
