- Garry Shandling
- Â Garry Shandling 72 episodes, 1986-1990
- Molly Cheek
- Â Nancy Bancroft 71 episodes, 1986-1990
- Michael Tucci
- Â Pete Schumaker / ... 71 episodes, 1986-1990
- Scott Nemes
- Â Grant Schumaker 70 episodes, 1986-1990
- Paul Willson
- Â Leonard Smith 47 episodes, 1986-1990
- Bernadette Birkett
- Â Jackie Schumaker 42 episodes, 1986-1990
- Barbara Cason
- Â Ruth Shandling 30 episodes, 1986-1990
- Ian Buchanan
- Â Ian McFyfer / ... 20 episodes, 1988-1990
- Jessica Harper
- Â Phoebe Bass 19 episodes, 1989-1990
- Richard Fancy
- Â Mr. Stravely / ... 8 episodes, 1988-1990
- Bruno Kirby
- Â Brad Brillnick 8 episodes, 1989-1990
- Geoffrey Blake
- Â Lewis 6 episodes, 1986
- Kate Mulligan
- Â Bethany / ... 6 episodes, 1986-1989
- Roy Brocksmith
- Â Mr. Guest 6 episodes, 1988-1990
- Chi Ngo
- Â Kim Moon 6 episodes, 1988-1990
- Rob Reiner
- Â Rob Reiner 4 episodes, 1987-1989
- Tom Petty
- Â Tom Petty 4 episodes, 1987-1989
- Scott Sherk
- Â Young Garry / ... 4 episodes, 1987-1988
- Danny Dayton
- Â Mr. Peck 4 episodes, 1988-1989
- Martin Mull
- Â Martin Mull 4 episodes, 1989-1990
- Blake Clark
- Â Blake Cumbers / ... 3 episodes, 1987-1988
- Paul Feig
- Â Chester Bass 3 episodes, 1990
- Richard Karron
- Â The Priest / ... 3 episodes, 1986-1988
- Jay Kogen
- Â Big Grant / ... 3 episodes, 1987-1990
- Don Amendolia
- Â Richie 3 episodes, 1989-1990
- Red Buttons
- Â Red Buttons 2 episodes, 1987-1989
- Don Novello
- Â Father Guido Sarducci 2 episodes, 1986-1989
- Chevy Chase
- Â Chevy Chase 2 episodes, 1989
- Dave Coulier
- Â Dave Coulier / ... 2 episodes, 1989-1990
- Jason Bernard
- Â Officer Sweeny 2 episodes, 1986-1987
- Jennifer Tilly
- Â Angelica 2 episodes, 1987
- Shawn Ora Engemann
- Â Sarah Reynolds / ... 2 episodes, 1986-1987
- Christian Clemenson
- Â Al / ... 2 episodes, 1987
- Dabney Coleman
- Â Dabney Coleman 2 episodes, 1989-1990
- Carl Reiner
- Â Carl Reiner 2 episodes, 1988-1989
- Christine Kellogg
- Â Charlene the Goddess of Ping-Pong / ... 2 episodes, 1986-1988
- Dom Irrera
- Â Dominic / ... 2 episodes, 1987-1988
- Zachary Bostrom
- Â Marshall Coleman 2 episodes, 1989
- Suzanne Kent
- Â The Nurse / ... 2 episodes, 1986
- Amzie Strickland
- Â Ma Schumaker / ... 2 episodes, 1987-1988
- Dick Tufeld
- Â Dick Tufeld / ... 2 episodes, 1987
- Edie Adams
- Â Clair King / ... 2 episodes, 1989-1990
- Lucy Webb
- Â Lucy Coleman 2 episodes, 1989
- Peggy Doyle
- Â Paula Hanlon / ... 2 episodes, 1989
- Bill Harris
- Â Bill Harris 2 episodes, 1990
- Chuck Woolery
- Â Chuck Woolery 2 episodes, 1987
- Bert Convy
- Â Bert Convy 2 episodes, 1988-1990
- Michael McManus
- Â Man in Cemetery / ... 2 episodes, 1988
- Blake Sennett
- Â Mario Shandling / ... 2 episodes, 1988-1990
- Joy Behar
- Â Joy Mull / ... 2 episodes, 1989-1990
- Brandon Crane
- Â Joey / ... 2 episodes, 1989
- Marvin Roberts
- Â Marvin 2 episodes, 1986
- Stuart Pankin
- Â Garry's Brain / ... 2 episodes, 1989-1990
- Debrah Farentino
- Â Debrah 2 episodes, 1989
- David Vaughn
- Â Second Basketball Player 2 episodes, 1986
- James F. Dean
- Â Singer #2 2 episodes, 1987
- David Wells
- Â Singer #3 2 episodes, 1987
- David Wood
- Â David Wood 1 episode, 1988
- Steve Allen
- Â Steve Allen 1 episode, 1989
- Charlie Callas
- Â Charlie Callas 1 episode, 1989
- Florence Henderson
- Â Florence Henderson 1 episode, 1987
- Ed Ames
- Â Ed Ames 1 episode, 1987
- Kurt Fuller
- Â Adam's Dad 1 episode, 1988
- Michelle Nicastro
- Â Shandlingland Nancy 1 episode, 1988
- Norman Fell
- Â Norman Fell 1 episode, 1986
- Vanna White
- Â Vanna White 1 episode, 1986
- Norm Crosby
- Â Norm Crosby 1 episode, 1986
- Ted Dawson
- Â Ted Dawson 1 episode, 1986
- David Paymer
- Â Richard Kimble 1 episode, 1987
- Tina Lifford
- Â Nurse Helen 1 episode, 1987
- Priscilla Weems
- Â Kim Stevens 1 episode, 1987
- Charles Conrad
- Â Charles Conrad 1 episode, 1987
- Kimberly Tamura
- Â Lily Woo 1 episode, 1987
- Jeff Goldblum
- Â Jeff Goldblum 1 episode, 1988
- Gilda Radner
- Â Gilda Radner 1 episode, 1988
- Dick O'Neill
- Â Mr. Sparks 1 episode, 1988
- Danny Mora
- Â Angry Dad #3 1 episode, 1988
- The Turtles
- Â The Turtles 1 episode, 1988
- Kurt Rambis
- Â Kurt Rambis 1 episode, 1988
- Bibi Besch
- Â Mrs. Robertson 1 episode, 1986
- Jason Naylor
- Â Renaldo 1 episode, 1986
- Claudia Christian
- Â Sylvia 1 episode, 1987
- June Lockhart
- Â June Lockhart 1 episode, 1987
- Susan Anton
- Â Susan Anton 1 episode, 1987
- Dennis Patrick
- Â Dr. Paul Derwin 1 episode, 1987
- Joseph Mascolo
- Â Lt. Gerard 1 episode, 1987
- Kevin Scannell
- Â Tim 1 episode, 1987
- Alan Haufrect
- Â The Hypnotist 1 episode, 1987
- Ed Morgan
- Â General Wernick 1 episode, 1987
- Lydia Bornino
- Â Studio Page 1 episode, 1987
- Michael Ensign
- Â Store Manager 1 episode, 1988
- Alan Blumenfeld
- Â Mr. Petersen 1 episode, 1988
- Diana Lewis
- Â TV Reporter 1 episode, 1988
- Melanie Gaffin
- Â Nancy 1 episode, 1988
- Harry S. Murphy
- Â Floyd's Dad 1 episode, 1988
- Howard Kaylan
- Â Howard Kaylan 1 episode, 1988
- Sal Viscuso
- Â Sal DeMarco 1 episode, 1989
- Cristina Ferrare
- Â Cristina Ferrare 1 episode, 1989
- Tony Orlando
- Â Tony Orlando 1 episode, 1989
- Richard Bull
- Â Stanley 1 episode, 1986
- Johnny Green
- Â Cub Scout 1 episode, 1986
- Lesa Lee
- Â Gorgeous Dream Babe 1 episode, 1986
- Chris Mulkey
- Â Sylvia's Ex-Boyfriend 1 episode, 1987
- Zsa Zsa Gabor
- Â Zsa Zsa Gabor 1 episode, 1987
- Ian Abercrombie
- Â Fate 1 episode, 1987
- Stan Ivar
- Â Donald Rapaport 1 episode, 1987
- Marty Allen
- Â Marty Allen 1 episode, 1987
- Dana Stevens
- Â Ticket Booth Girl 1 episode, 1987
- Martin Garner
- Â Mr. Schumacher 1 episode, 1987
- Adam Englund
- Â Young Man 1 episode, 1987
- Peter Crook
- Â Maitre d' 1 episode, 1987
- Jocko Marcellino
- Â The D.J. 1 episode, 1987
- Lydie Denier
- Â French Woman in Black 1 episode, 1988
- Mina Kolb
- Â Rose Wachs 1 episode, 1988
- David Greenlee
- Â Young Leonard Smith 1 episode, 1988
- Joe Mays
- Â Benedict 1 episode, 1988
- Mark Volman
- Â Mark Volman 1 episode, 1988
- David Muir
- Â Waiter 1 episode, 1988
- Tom Bradley
- Â Tom Bradley 1 episode, 1988
- Donna Taylor
- Â Donna Taylor 1 episode, 1988
- Finola Hughes
- Â Anna Devane 1 episode, 1989
- Sheena Easton
- Â Sheena Easton 1 episode, 1989
- Bruce Kirby
- Â Eddy King 1 episode, 1989
- Lou Hancock
- Â Mrs. Tischler 1 episode, 1989
- Roy Firestone
- Â Roy Firestone 1 episode, 1989
- Howard Mungo
- Â Coach Roy London 1 episode, 1989
- Steve Edwards
- Â Steve Edwards 1 episode, 1989
- Chris Isaak
- Â Chris Isaak 1 episode, 1990
- David Byrd
- Â Uncle Garth 1 episode, 1990
- Edward Penn
- Â Gil Bass 1 episode, 1990
- Michael Arabian
- Â Captain Jumbo McGee 1 episode, 1990
- Cliffy Magee
- Â Cub Scout 1 episode, 1986
- Bader Howar
- Â Elaine Robertson 1 episode, 1986
- Kamala Lopez
- Â Maria Herrera 1 episode, 1987
- Doc Severinsen
- Â Doc Severinsen 1 episode, 1987
- Chance Quinn
- Â Bully 1 episode, 1987
- Bruce Mickelson
- Â Bentley 1 episode, 1987
- Steve Belin
- Â Garry Shandling Dancer 1 episode, 1987
- Kurtwood Smith
- Â Paul Bosgang 1 episode, 1988
- Holly Fields
- Â Madeline 1 episode, 1988
- Byron Morrow
- Â The Doctor 1 episode, 1988
- Lew Gallo
- Â Norman Wachs 1 episode, 1988
- Dena Dietrich
- Â Miss Ferguson 1 episode, 1988
- Don Cornelius
- Â Don Cornelius 1 episode, 1988
- Wynn Irwin
- Â Eddie 1 episode, 1988
- Blackie Dammett
- Â Nathan 1 episode, 1989
- Paula Poundstone
- Â Paula Poundstone 1 episode, 1989
- Jeff Doucette
- Â Fred Wozniak 1 episode, 1989
- Shell Kepler
- Â Amy Vining, R.N. 1 episode, 1989
- Jerry Winsett
- Â Barker 1 episode, 1989
- Maurice Hill
- Â Otto 1 episode, 1989
- Fawne Harriman
- Â Mrs. Kramer 1 episode, 1989
- Eugene Choy
- Â Theme Song Singer 1 episode, 1989
- Anne Haney
- Â Aunt Arla 1 episode, 1990
- Patrick Cronin
- Â Al Pine 1 episode, 1990
- J. Patrick McNamara
- Â Dr. Richard Mellie 1 episode, 1990
- Lynnette Mettey
- Â Dr. Brody 1 episode, 1986
- Jean Adams
- Â Jean 1 episode, 1986
- Raven Pearce
- Â Cub Scout 1 episode, 1986
- Jack Wells
- Â Jack Wells 1 episode, 1987
- Sam Grey
- Â Baby Boy Shumaker 1 episode, 1987
- Angelique De Windt
- Â Amaretto Jones / ... 1 episode, 1987
- Larry Blum
- Â Garry Shandling Dancer 1 episode, 1987
- Yana Nirvana
- Â Woman in Bed 1 episode, 1988
- Marty Zagon
- Â Pa Schumaker 1 episode, 1988
- Michelle Stevenson
- Â Mary 1 episode, 1988
- John George Campbell
- Â Singing Plumber 1 episode, 1988
- Jose Aguilar
- Â Soccer Player 1 episode, 1988
- Heather Hopper
- Â Carolyn 1 episode, 1989
- George D. Wallace
- Â Father Tom 1 episode, 1989
- Linda Doucett
- Â Susan 1 episode, 1989
- David Wysocki
- Â Dr. Tom Hardy 1 episode, 1989
- Robin Bach
- Â Steward 1 episode, 1989
- David Hooks
- Â Dr. Jeremiah Bosgang 1 episode, 1989
- Joseph Paur
- Â Joseph Roveto 1 episode, 1989
- Mark Sweet
- Â Mark Suite 1 episode, 1989
- Barry Richards
- Â Dancing Barry 1 episode, 1989
- Dan Aykroyd
- Â Boolie Shandling 1 episode, 1990
- Ryan Stiles
- Â Bob #2 / ... 1 episode, 1990
- Mark Blankfield
- Â Phantom of the Studio 1 episode, 1990
- Gwynyth Walsh
- Â Helen Falls 1 episode, 1990
- Jack Dodson
- Â Howard Sprague 1 episode, 1990
- Eddie Jones
- Â Uncle Elliot 1 episode, 1990
- Adam Biesk
- Â Ryan 1 episode, 1990
- Paul Tinder
- Â Larry Lewis 1 episode, 1990
- Armin Shimerman
- Â The Doctor 1 episode, 1986
- Lloyd Bremseth
- Â Lloyd 1 episode, 1986
- Ken Olfson
- Â The Executive 1 episode, 1986
- Murphy Cross
- Â Garry Shandling Dancer 1 episode, 1987
- Valerie Breiman
- Â Vicky 1 episode, 1987
- Bradley Fisher
- Â Thug #1 1 episode, 1987
- Julie Moran
- Â Gary's Dream Wife 1 episode, 1987
- Irene Tedrow
- Â Grandma Shandling 1 episode, 1988
- Juliette Hagerman
- Â Elizabeth 1 episode, 1988
- Tony Torres
- Â Soccer Player 1 episode, 1988
- Brad Laughlin
- Â Game Player 1 episode, 1988
- Mitch Gordon
- Â Singing Plumber 1 episode, 1988
- Henry Winkler
- Â Henry Winkler 1 episode, 1989
- Marcia Cross
- Â Christine 1 episode, 1989
- Victor DiMattia
- Â Billy 1 episode, 1989
- Lisa Jane Persky
- Â Kitty 1 episode, 1989
- Lionel Stander
- Â Lionel Stander 1 episode, 1989
- Christie Clark
- Â Cindi 1 episode, 1989
- Jason Horst
- Â Steve 1 episode, 1989
- Constance Ball
- Â Mother 1 episode, 1989
- Tony Danza
- Â Tony Danza 1 episode, 1990
- Paul Winfield
- Â Hoke 1 episode, 1990
- William Shockley
- Â Roach 1 episode, 1990
- Lyle Alzado
- Â Lyle Alzado 1 episode, 1990
- Richard Roat
- Â Father Bob 1 episode, 1990
- Mimi Rose
- Â Darcy Shandling 1 episode, 1990
- James Waterhouse
- Â Waiter 1 episode, 1990
- Denis Lacombe
- Â Jacques 1 episode, 1990
- Richard Biggs
- Â Young Doctor #1 1 episode, 1986
- Raechel Donahue
- Â Dr. Burkes 1 episode, 1986
- Tony Plana
- Â Jorge Herrera 1 episode, 1987
- Laura Wernette
- Â Francine 1 episode, 1987
- James Staszkiel
- Â Thug #2 1 episode, 1987
- Dani Douthette
- Â Garry Shandling Dancer 1 episode, 1987
- Jim Wise
- Â Game Player 1 episode, 1988
- Angelo Tiffe
- Â Rescue Worker 1 episode, 1988
- John Harlan
- Â Announcer 1 episode, 1988
- Mitchel D. Moore
- Â Singing Plumber 1 episode, 1988
- Philip Bruns
- Â Older Garry 1 episode, 1989
- Ryan Lambert
- Â Arnold Kramer 1 episode, 1989
- Prudence Wright Holmes
- Â Audience Member 1 episode, 1989
- Gwen E. Davis
- Â Gwen Frazier 1 episode, 1989
- Scott Hunter
- Â Dad 1 episode, 1989
- Bob Newhart
- Â Bob Newhart 1 episode, 1990
- Ned Beatty
- Â Ned Beatty 1 episode, 1990
- David Viscott
- Â Dr. David Viscott 1 episode, 1990
- Tom Noga
- Â Furniture Mover 1 episode, 1986
- Sally Ann Miller
- Â Blonde Babe #1 1 episode, 1986
- Douglas DuVal
- Â Counterman 1 episode, 1987
- Keith Ellinger
- Â Garry Shandling Dancer 1 episode, 1987
- Keith Campbell
- Â Stunt Garry 1 episode, 1988
- Gordon Goodwin
- Â Jerome 1 episode, 1988
- Joe Wendt
- Â Blue Suede Schumaker 1 episode, 1988
- Bobby McGee
- Â Audience Member 1 episode, 1989
- Christopher John Fields
- Â Mike 1 episode, 1989
- Eric Poppick
- Â Mr. Kramer 1 episode, 1989
- Theodocia Goodrich
- Â Older Phoebe 1 episode, 1989
- Helena Carroll
- Â Ian's Mother 1 episode, 1990
- Al Pugliese
- Â Furniture Mover 1 episode, 1986
- Clark Sayre
- Â Young Doctor #3 1 episode, 1986
- Ed Herlihy
- Â Announcer 1 episode, 1987
- Tricia McFarlin
- Â Garry Shandling Dancer 1 episode, 1987
- Rick Zumwalt
- Â Barbara Bush 1 episode, 1988
- J.A. Preston
- Â Mr. Ryan 1 episode, 1989
- Jean Sincere
- Â Audience Member 1 episode, 1989
- Tai Babilonia
- Â Tai Babilonia 1 episode, 1990
- Kitty Swink
- Â Young Doctor #2 1 episode, 1986
- Don Sparks
- Â Audience Member 1 episode, 1989
- Randy Gardner
- Â Randy Gardner 1 episode, 1990
- Kerry Slattery
- Â Kerry 1 episode, 1986
- Charles Nelson Reilly
- Â Charles Nelson Reilly 1 episode, 1990
- Connie Stevens
- Â Connie Stevens 1 episode, 1990
- Andy Goldberg
- Â Joseph 1 episode, 1990
- Nick LaTour
- Â Reverend 1 episode, 1990
- Eliana Alexander
- Â Bridesmaid 1 episode, 1990
- Michael Davis
- Â Michael Davis 1 episode, 1989
- Randy Allaire
- Â Usher 1 episode, 1990
- Carl Carlsson
- Â Carl Carlsson 1 episode, 1989
- Jodie McDonald
- Â Bridesmaid 1 episode, 1990
- Ruth Carlsson
- Â Ruth Carlsson 1 episode, 1989
- Telma Hopkins
- Â Telma Hopkins 1 episode, 1989
- Joyce Vincent Wilson
- Â Joyce Vincent Wilson 1 episode, 1989
- Cliff Emmich
- Â Santa Claus 1 episode, 1987
- Kathy Valentino
- Â Mrs. Shandberg 1 episode, 1987
- JoAnn Willette
- Â Gary in Shandlingland 1 episode, 1988
- Randy West
- Â TV Wedding Announcer 1 episode, 1990
- Peter Barth
- Â Peter Barth (uncredited) 4 episodes, 1986-1987
- Chester Jackson
- Â Chester Jackson (uncredited) 3 episodes, 1988-1989
- Todd Baker
- Â Bartender / ... (uncredited) 3 episodes, 1990
- Bettina Mylenek
- Â Bettina Mylenek / ... (uncredited) 2 episodes, 1989-1990
- Jodi Jones
- Â Jodi Jones (uncredited) 1 episode, 1986
- Bruce Bonnett
- Â Bruce Bonnett (uncredited) 1 episode, 1987
- Jeff Barnes
- Â Jeff Barnes (uncredited) 1 episode, 1989
- David Millbern
- Â Dancing Groomsman / ... (uncredited) 1 episode, 1990
- Michael V. Scott
- Â Video Store Patron (uncredited) 1 episode, 1990
