- Linda Blair
- Jamie (segment "Don't")
- Barbara Bosson
- Pam (segment "Sale on Professional Men")
- Georg Stanford Brown
- Charlie (segment "Unhappy Hour")
- Ray Buktenica
- Bob (segment "Long Distances")
- Colleen Camp
- Young Lady (segment "Worst Fears")
- John Carradine
- Gentleman (segment "Great Moments")
- Marilyn Chambers
- Marilyn (segment "Marilyn")
- Sybil Danning
- Sherry (segment "Long Distances")
- Julia Duffy
- Marjorie (segment "Soap")
- Squire Fridell
- Newscaster (segment "Sale on Professional Men")
- Brodie Greer
- Burt (segment "Weekends")
- Rich Hall
- Announcer (segment "Ho")
- Deborah Harmon
- Mom (segment "3-Mile Island People)
- Sunny Johnson
- Missy (segment "Hannuka Horror")
- David L. Lander
- Fritz #1 (segment "Interrogation")
- Audrey Landers
- Lois (segment "Dandruff")
- Kim Lankford
- Woman (segment "Confident")
- Meadowlark Lemon
- Willie (segment "Man on the Moon")
- Michael McKean
- Fritz #2 (segment "Interrogation")
- James MacKrell
- Voice Over Announcer
- Ed Marinaro
- Phil (segment "Worst Fears")
- Diana Muldaur
- Missus Toni (segment "Hola")
- Barry Pearl
- Bob (segment "Bookreading")
- William Sanderson
- Carl (segment "Alienski")
- Peter Scolari
- Phil (segment "Dandruff")
- Bob Seagren
- Frank (segment "Large World of Sport")
- James Sikking
- Dracula (segment "Lite Blood")
- P.J. Soles
- Young Lady (segment "Soda")
- Wendie Jo Sperber
- Marquesse de Sade (segment "Rock Video")
- Byron Stewart
- Mohammed (segment "Large World of Sport")
- Jennifer Tilly
- Joni (segment "Sale on Professional Men")
- Jimmie 'JJ' Walker
- Thomas (segment "Man on the Moon")
- Bruce Weitz
- Larry (segment "Worst Fears")
- Fred Willard
- Dad (segment "3-Mile Island People")
- George Wyner
- Irving Rosenbloom Private Eye (segment "Hannuka Horror")
- Keenan Wynn
- Charlie (segment "Man on the Moon")
- Miguel A. Núñez Jr.
- Bopper (segment "Music")
- Karen Montgomery
- Secretary (segment "Tied Up")
- Marie-Alise Recasner
- Stewardess (segment "Goodbye")
- Tracy Vaccaro
- Marlene (segment "Marlene")
- Mike George
- Lance (segment "Sale on Professional Men")
- Doyle Baker
- Executive (segment "Alarm")
- Ed Berke
- Held-up Man (segment "Alarm")
- Karen Mayo-Chandler
- Secretary (segment "Alarm")
- Robert Sherman
- Delivery Man (segment "Alarm")
- Shawn Alexander Campbell
- Billy (segment "3-Mile Island People")
- Jill Norton
- Suzy (segment "3-Mile Island People")
- Wendie Griffin
- Cheerleader (segment "Large World of Sport")
- Robin Hoff
- Melanie (segment "Large World of Sport") / Secretary (segment "Unhappy Hour") (archive footage)
- J.W. Smith
- Receiver (segment "Large World of Sport")
- Hank Cunnington
- Donald #1 (segment "Soap")
- Lisa Fuller
- Stephanie (segment "Soap")
- Denise Gauthier
- Sheila (segment "Soap")
- Ron Hayes
- Donald #2 (segment "Soap")
- Don Lara Jr.
- Romano (segment "Soap")
- Russ Parsons
- Seth (segment "Soap")
- Pamela West
- Rhonda (segment "Soap")
- Gail Davis
- Wicked Witch (segment "Shake and Cook")
- Mason Nupuf
- Hansel (segment "Shake and Cook")
- Ron Sloan
- Ogre (segment "Shake and Cook")
- Wilson Camp
- Businessman (segment "Unhappy Hour")
- Paul Cavonis
- Construction Worker (segment "Unhappy Hour")
- Marvin Cohen
- Bartender (segment "Unhappy Hour")
- Lou Michaels
- Compaining Wife (segment "Unhappy Hour")
- Michael Preminger
- Compaining Husband (segment "Unhappy Hour")
- Paul Sylvan
- Hate' Man (segment "Unhappy Hour")
- Jere Rae Mansfield
- Daughter (segment "Heads") / Young Lady (segment "I Told Two Friends") (archive footage) (as Jere Lea Rae)
- Niki Rae
- Mother (segment "Heads") / Punker (segment "Ho") (archive footage)
- Joshua Grenrock
- Fencer #1 (segment "Coming Attractions")
- Scott Ingram
- Fencer #2 (segment "Coming Attractions")
- Lynda Wiesmeier
- Bambi (segment "Coming Attractions")
- Dennis Bowen
- WWII Flyer (segment "Interrogation")
- Don Bovingloh
- Father (segment "Quaaludes for Kids")
- Gregory Levinson
- Bret (segment "Quaaludes for Kids")
- De'Ann Power
- Wench (segment "Lite Blood")
- Dolores Cantu
- Maid (segment "Hola")
- Pilar Delano
- Cavewoman (segment "Headache")
- Leslie Shenkel
- Inventor Caveman (segment "Headache")
- Stuart Rankine
- Burly Caveman (segment "Headache")
- Joel Blasberg
- Rabbi (segment "Hannuka Horror")
- Susan Gordon
- Shelly (segment "Hannuka Horror")
- Mark Lowenthal
- Bart (segment "Hannuka Horror")
- Joel Rice
- Ronnie (segment "Hannuka Horror")
- Sara Lee Wade
- Missy's Friend (segment "Hannuka Horror")
- Bill Elliott Feingold
- Ezra and the Four Feingolds (segment "Hannuka Horror")
- Chuck Fiore Feingold
- Ezra and the Four Feingolds (segment "Hannuka Horror")
- Dennis Herring Feingold
- Ezra and the Four Feingolds (segment "Hannuka Horror")
- Arno Lucas Feingold
- Ezra and the Four Feingolds (segment "Hannuka Horror")
- Beau Segal Feingold
- Ezra and the Four Feingolds (segment "Hannuka Horror")
- Scott Mansfield
- Ezra Birnbaum (segment "Hannuka Horror")
- Lloyd Alan
- Dino Dante (segment "Ho")
- Meredith Eisenberg
- Young Girl (segment "Ho")
- Wendy Hoffman
- Bubbles (segment "Ho")
- Garth Stevens
- Young Dino (segment "Ho")
- Joe Colligan
- Arthur (segment "Making Out")
- Carey Salley
- Valerie (segment "Making Out")
- Steve Tannen
- Delivery Man (segment "Confident")
- Christine Bayly
- Lilli (segment "Bonahue")
- Scott Feinstein
- C.P.A. (segment "Bonahue")
- Jerry Lacy
- Bill (segment "Bonahue")
- Erika Eleniak
- Brooke Shields (segment "Jeans")
- Paul Thomas
- Roger (segment "Bookreading")
- Lori Wagner
- Sheila (segment "Bookreading")
- Lisa Fong
- Oriental Mom (segment "Moms")
- Andrew Louie
- Oriental Son (segment "Moms")
- Marla Pennington
- American Mom (segment "Moms")
- Joey Tushnet
- American Son (segment "Moms")
- Danny Robinson
- Don (segment "Man on the Moon")
- Sandra Ann Will Carradine
- Sheila (segment "Weekends")
- Newell Alexander
- Bob (segment "My Broker")
- John Howard Swain
- Businessman (segment "My Broker")
- Ruble Maxwell Blakey
- Janitor (segment "Nutsy Glue")
- Gerald Griffin
- Scientist (segment "Nutsy Glue")
- Jeffery Kramer
- Announcer (segment "Nutsy Glue")
- Fred Fox Jr.
- Assistant Director (segment "Millertime")
- Karen Lorre
- Randy Miller (segment "Millertime")
- Matilda
- The Wonder Bunny
- Ron Roy
- Jogger (segment "Wabbitt")
- Corey Burton
- Voice Over Announcer
- Rich Hall
- Presenter
