- Nick Offerman
- Self - Host / Scientist
- Sting
- Self - Musician
- A$AP Rocky
- Self - Musician
- Bill Kreutzmann
- Self - The Grateful Dead
- Rosie Perez
- Self - Actress
- Reggie Watts
- Self - Comedian
- Robert Ben Garant
- Self - Actor & Writer
- Thomas Lennon
- Self - Actor & Writer
- Brett Gelman
- Self - Actor / Misbehaving Acorn
- Will Forte
- Self - Actor
- David Cross
- Self - Actor
- Carrie Fisher
- Self
- Natasha Lyonne
- Self - Actress
- Anthony Bourdain
- Self - Chef
- Ben Stiller
- Self - Actor
- Deepak Chopra
- Self - Author
- Sarah Silverman
- Self - Comedian
- David Koechner
- Self - Actor
- Andy Richter
- Self - Actor
- Judd Nelson
- Self - Actor
- Jim James
- Self - Musician
- Diedrich Bader
- Self - Actor
- Steve Agee
- Self - Comedian
- Lewis Black
- Self - Comedian
- Charles Grob
- Self - Professor of Psychiatry, UCLA
- Rob Huebel
- Self - Actor
- Nick Kroll
- Self - Actor / Kelp Monster
- Rob Corddry
- Self - Actor / Paul Scheer
- Matt Besser
- Self - Comedian
- Adam Horovitz
- Self - Musician, Beastie Boys
- Kathleen Hanna
- Self - Musician, Bikini Kill
- Paul Scheer
- Self - Comedian / Rob Corddry
- Donovan
- Self - Musician, Hurdy Gurdy Man
- Zach Leary
- Self - Timothy Leary's Son
- Marc Maron
- Self - Actor
- Shepard Fairey
- Self - Artist
- James Adomian
- Animation Voices
- Adam Scott
- After School Special Host
- Riki Lindhome
- Emily
- Armen Weitzman
- Drug Dealer
- Ron Funches
- Ron
- Maya Erskine
- Maya
- Haley Joel Osment
- Gabe
- Adam Devine
- Young Anthony Bourdain
- Blake Anderson
- Anthony Bourdain's Friend
- Angela Trimbur
- Panama Red
- Cate Beehan
- Panama's Friend
- Otis Montfort Manning Cary
- Captain Good Trips
- Natasha Leggero
- Young Carrie Fisher
- Bill Kottkamp
- Drug Prankster
- Amadi Jean Cary
- The Glimmer of Hope Girl
- Nelson Franklin
- Young Lewis Black
- Fred Willard
- The 'Just Hang On!' Man
- David Futernick
- Lewis Black's Friend
- Ren Hanami
- Moms
- George Harrison
- Self - Musician
- Bill Hicks
- Self - Comedian
- Timothy Leary
- Self - Psychologist
- Jerry Shaw
- Self - Associate Professor of Psychology, San Fernando Valley State College
- Lisa Y. Sheeler
- Anthony Bourdain's Mother
- Michele Love Santoro
- Young Lewis Black's Friend
