- Cynthia Erivo
- Harriet / Minty
- Leslie Odom Jr.
- William Still
- Joe Alwyn
- Gideon Brodess
- Clarke Peters
- Ben Ross
- Vanessa Bell Calloway
- Rit Ross
- Omar J. Dorsey
- Bigger Long
- Henry Hunter Hall
- Walter
- Tim Guinee
- Thomas Garrett
- Nick Basta
- Foxx
- Joseph Lee Anderson
- Robert Ross
- Antonio J Bell
- Henry Ross
- CJ McBath
- Junyah Ross
- Alexis Louder
- Jane
- Aria Brooks
- Anger (8)
- Janelle Monáe
- Marie Buchanon
- Zackary Momoh
- John Tubman
- Frank Riley III
- Joe
- Daphne Reid
- Miz Lucy
- Jenna Marie Hess
- Phoebe
- Kathryn Tkel
- Tilly
- Vondie Curtis-Hall
- Reverend Green
- Jennifer Nettles
- Eliza Brodess
- Deborah Ayorinde
- Rachel Ross
- Mike Marunde
- Edward Brodess
- Kamillah Matthews
- Soph
- Rakeem Laws
- Jasper Marley
- Tory Kittles
- Frederick Douglass
- Tia L. Davis
- Linah
- Mitchell Hoog
- Vince (16)
- Liam Searcy
- Victor (16)
- Keith Tyree
- Sidney Howard Gay
- Thomas Keegan
- Sherriff Ned Utley
- Jaben Early
- John Clay
- Don Hartman
- Gus Vern
- Pete Burris
- Lawman
- Damian Allen
- Planter
- David Dickson Reynolds
- White Minister
- William Flaman
- A.C. Thompson
- William L. Thomas
- Senator Seward
- James W. Hester
- Farmer
- Laureen E. Smith
- Martha Coffin Wright
- Brian K. Landis
- Marshal
- Morgan Mccoy
- Jesse
- Bostin Christopher
- Local Statesman
- Coby Noel Batty
- Foot Patrol Man
- Nigel Reed
- John Brown
- Eli El
- Man on Dock
- Carlos Thompson
- Unseen Man
- Michael Tourek
- Slave Owner
- Philip Anastasi
- Guard
- Seth Lee Moore
- Victor (12)
- Helen Goldsby
- Hany
- Kendrix Lamaz Brown
- Mack
- LondonRose Sellars
- Anger (4)
- Antonio Perez Kemp
- George Wilmer
- Claire Bronson
- Rachel Garrett
- Willie Raysor
- Abraham
- Joshua T. Shipman
- Philly Vendor
- Eleanor Buchanan Duffey
- Becky (14)
- Darnell Adkins
- Union Soldier
- Aaron Angus
- Lawman
- Kia Bennett
- Merchant
- Jacob Brankley
- Mercenary
- Taryn Brown
- PASS Worker
- April Buckles
- Caroline
- Andrew James Burst
- Union Soldier
- Cris Chaffee
- Plantation Owner
- Kalonji Changa
- Freed Slave
- Charles D. Clark
- Abolitionist / John Brown Bodyguard (uncredited)
- Arnold Coleman
- Freed Slave / Thomas Mill Worker (uncredited)
- Yamanee Coleman
- Slave
- Chris Condetti
- Vigilante
- Margie Curran
- Upper Class Woman
- Paul D'Elia
- Baltimore Slave Owner
- Javon Davis
- Soldier
- Gerron DelValle
- Free Man
- Arykah Naomi DeVaughn
- Angerine (2 / 3) (uncredited)
- John Dever
- Vigilante Slave Holder
- Lisa Edmondson
- Fashionable Lady
- Victor Ellis
- Soldier
- Ronson Giggetts
- Union Soldier
- Jourin Hannah
- Slave Testifier
- Jack Hoke
- Un-Named Slave States Rights Supporter
- John S. Howell Sr.
- Boston Pedestrian
- Wain Jenkins
- UGRR Passenger
- Darren Johnson
- Union Soldier
- Raymond H. Johnson
- U.S. Marshal
- Bob Jones
- Maryland Lawman
- Paris Jones
- Run Away Slave
- William Kaffenberger
- Abolitionist
- Carena Lemons
- PASS Worker
- David Milks
- Vigilante
- Destiny Moné
- Church Congregant
- Nydell Nalls
- Soldier
- Garon Nedrick
- Union Soldier
- Corey T. Norman
- Slave / Union Soldier (uncredited)
- Samuel Okine
- Union Soldier
- Chris Smorto
- Lawman
- Ijon Stewart
- Displaced Person
- Chuck Taber
- John Brown Supporter
- Debbie Terrell
- Freedom Seeker
- John Thomas
- Onlooker
- William G. Tomek
- Senator's Armed Guard
- Alana Tyson
- Slave fleeing
- Micah West
- PASS Worker
- Antoine D Williams
- Union Soldier
- Shakiah Williams
- Congregant
- Logan J. Woolfolk
- UGRR Passenger
- Charles Young
- Issac
