- Dave Chappelle
- Thurgood / Sir Smoka Lot
- Guillermo Diaz
- Scarface
- Jim Breuer
- Brian
- Harland Williams
- Kenny
- Rachel True
- Mary Jane
- Clarence Williams III
- Samson Simpson
- Laura Silverman
- Jan
- Tommy Chong
- Squirrel Master
- R.D. Reid
- Scientist
- Gregg Rogell
- Pothead
- Kevin Brennan
- Pothead
- Alice Poon
- Supply Clerk
- Rick Demas
- Nasty Nate
- David Bluestein
- Jerry Garcia
- Kevin Duhaney
- Young Thurgood
- Matthew Raposo
- Young Scarface
- James Cooper
- Young Brian
- Michael Colton
- Young Kenny
- Paul Brogren
- Burger Customer
- Neal Brennan
- Employee
- Karen Waddell
- Record Store Employee
- Vincent Marino
- Bodega Man
- Domencio 'Macio' Parrilla
- Rasta Man
- Marcus Burrowes
- Rasta Man
- Mark Henriques
- Delivery Guy
- Jenni Burke
- Overweight Woman
- Gwenne Hudson
- Bong Genie
- David Mucci
- Horse Cop
- Reg Dreger
- Judge
- Kevin Rushton
- Inmate
- Paul James Saunders
- Doorman
- Kyrin Hall
- Henchwoman
- Joanna Bacalso
- Henchwoman
- C.J. Lusby
- Henchwoman
- Angelica Lisk-Hann
- Henchwoman
- Jacqueline Buckingham
- Henchwoman
- Stephanie Bourgeois
- Henchwoman
- Ho Chow
- Hot Dog Vendor
- Rummy Bishop
- Homeless Guy
- Jon Stewart
- Enhancement Smoker
- Snoop Dogg
- Scavenger Smoker
- Stephen Baldwin
- McGuyver Smoker
- Marc Cohen
- McGuyver Friend
- Tracy Morgan
- V. J.
- David Edwards
- Addict
- Paulino Nunes
- Swat Cop
- Jason Blicker
- Detective
- Dave Nichols
- Detective
- Sharon Brown
- Talking Joint
- Christopher Mugglebee
- Security Guard
- Raymond Hinton
- Security Guard
- David Sutcliffe
- After School Dad
- Daniel DeSanto
- After School Son
- Gladys O'Connor
- Grandma Smoker
- Willie Nelson
- Historian Smoker
- Alice Dinnean
- Abigail
- Janeane Garofalo
- Poet Smoker
- Ginette Guimond
- Dancer
- Spencer Kayden
- Rehab Attendee
- Carson Manning
- Man at Bar
- Jody Millard
- Cedric
- Andy Rukes
- Prisoner
- Bob Saget
- Rehab Attendee
- Steven Wright
- The Guy on the Couch
