- Nell Carter
- Â Nell Harper 137 episodes, 1981-1987
- Lara Jill Miller
- Â Sam Kanisky 119 episodes, 1981-1987
- Lauri Hendler
- Â Julie Kanisky / ... 114 episodes, 1981-1986
- Kari Michaelsen
- Â Katie Kanisky 111 episodes, 1981-1986
- Dolph Sweet
- Â Chief Carl Kanisky / ... 88 episodes, 1981-1985
- John Hoyt
- Â Grandpa Stanley Kanisky / ... 82 episodes, 1982-1987
- Joey Lawrence
- Â Joey Donovan 77 episodes, 1983-1987
- Telma Hopkins
- Â Addy Wilson 68 episodes, 1983-1987
- Howard Morton
- Â Officer Ralph Simpson / ... 50 episodes, 1981-1986
- Matthew Lawrence
- Â Matthew Donovan 18 episodes, 1986-1987
- Rosetta LeNoire
- Â Maybelle 'Mama' Harper 16 episodes, 1985-1987
- Jonathan Silverman
- Â Jonathan Maxwell 16 episodes, 1984-1986
- Paul Sand
- Â Marty 11 episodes, 1986-1987
- Rosie O'Donnell
- Â Maggie O'Brien 10 episodes, 1986-1987
- Pete Schrum
- Â Uncle Ed Kanisky 9 episodes, 1982-1983
- Jane Dulo
- Â Grandma Mildred Kanisky 8 episodes, 1982-1983
- Harrison Page
- Â Hamilton Storm / ... 8 episodes, 1981-1984
- Don Bovingloh
- Â Desk Clerk 7 episodes, 1984-1986
- Alvernette Jimenez
- Â Angie 6 episodes, 1981-1985
- Don Sherman
- Â Lester / ... 6 episodes, 1982-1986
- Yvonne Wilder
- Â Dr. Fran Roberts / ... 5 episodes, 1986-1987
- Roslyn Kind
- Â Female Student / ... 5 episodes, 1983-1986
- Victoria Carroll
- Â Applicant #1 / ... 4 episodes, 1982-1983
- Robin Bach
- Â Cameraman / ... 4 episodes, 1982-1983
- Jack Fletcher
- Â Mr. Swackhammer 4 episodes, 1982-1983
- Rick Fitts
- Â Andrew / ... 4 episodes, 1983-1986
- Mark L. Taylor
- Â Mr. Broderick 4 episodes, 1986-1987
- Patrick Collins
- Â Tim Donovan 3 episodes, 1986
- James A. Watson Jr.
- Â James Roland 3 episodes, 1983-1984
- Jay Johnson
- Â Rev. Cunningham / ... 3 episodes, 1981-1982
- Lynne Thigpen
- Â Loretta Harper 3 episodes, 1985-1986
- Nat Bernstein
- Â Murphy / ... 3 episodes, 1984-1986
- Bonnie Urseth
- Â Doris / ... 3 episodes, 1982-1983
- Cliff Norton
- Â Mr. Bickford / ... 3 episodes, 1984-1985
- Hazel Shermet
- Â Mrs. Larry Rhine / ... 3 episodes, 1981-1982
- Nedra Volz
- Â Maid 3 episodes, 1984-1986
- Phil Leeds
- Â Mr. Galotta / ... 3 episodes, 1984-1985
- Don Frankel
- Â Larry 3 episodes, 1983-1986
- John Otrin
- Â Police Officer / ... 2 episodes, 1983-1985
- Joseph Maher
- Â Professor Dudley 2 episodes, 1987
- Patrick Breen
- Â Keith Dudley 2 episodes, 1987
- Jack Carter
- Â Corelli / ... 2 episodes, 1982
- Susan Marie Snyder
- Â Linda 2 episodes, 1987
- Rue McClanahan
- Â Katrina / ... 2 episodes, 1981-1984
- Teddy Wilson
- Â Club Owner / ... 2 episodes, 1984-1987
- Maggie Cooper
- Â Mary Beth Sinclair 2 episodes, 1983
- Lewis Arquette
- Â Coach Henderson / ... 2 episodes, 1982-1987
- Charles Weldon
- Â Good Ol' Charlie Johnson 2 episodes, 1984
- Gary Collins
- Â Gary Collins 2 episodes, 1986
- Frank Bonner
- Â Officer Baxter / ... 2 episodes, 1982-1985
- Hilda Haynes
- Â Emma Harper / ... 2 episodes, 1982-1983
- Michael Dorn
- Â Major Carpenter / ... 2 episodes, 1984-1986
- Kurt McKinney
- Â Chip / ... 2 episodes, 1985-1986
- Todd Field
- Â Eric 2 episodes, 1987
- Blake Clark
- Â B.J. O'Brien 2 episodes, 1987
- Phil Rubenstein
- Â Captain Luchesi / ... 2 episodes, 1982
- Fred McCarren
- Â Tim Donovan 2 episodes, 1984
- Pam Matteson
- Â Nurse #1 / ... 2 episodes, 1984
- Count Stovall
- Â Tony 2 episodes, 1985
- Jack Riley
- Â Jack 2 episodes, 1986
- Tonya Williams
- Â Judy Mitchell 2 episodes, 1987
- Nora Boland
- Â Edna / ... 2 episodes, 1981-1982
- Will Hunt
- Â Bill Larkin / ... 2 episodes, 1981-1982
- Arlene Golonka
- Â Maxine 2 episodes, 1982-1983
- Liz Torres
- Â Nurse #2 / ... 2 episodes, 1983-1984
- Jack Lindine
- Â The Mad Bomber 2 episodes, 1983
- Leonard Lightfoot
- Â Dr. Jamel Anderson / ... 2 episodes, 1984-1985
- Arnold F. Turner
- Â Fireman / ... 2 episodes, 1985-1986
- Marie-Alise Recasner
- Â Tammy 2 episodes, 1985
- George Memmoli
- Â Phil / ... 2 episodes, 1981-1982
- Allan Rich
- Â Judge 2 episodes, 1983
- Meredith Baker
- Â Helen 2 episodes, 1986-1987
- Hakeem Abdul-Samad
- Â Jerome 2 episodes, 1985
- Judy Walton
- Â Receptionist 2 episodes, 1984-1985
- Jason Edwards
- Â Dr. Ferguson Johnson 2 episodes, 1984
- René Le Vant
- Â Howard 2 episodes, 1985
- Jeremy Sunderland
- Â Customer / ... 2 episodes, 1984-1985
- Shari Shaw
- Â Sandy 2 episodes, 1986
- Patricia Veselich
- Â Karen / ... 2 episodes, 1983-1985
- William G. Schilling
- Â Police Officer #1 2 episodes, 1983
- Case Strassner
- Â Baby / ... 1 episode, 1983-1984
- Shelly Garrett
- Â Earl / ... 2 episodes, 1986-1987
- Paul Williams
- Â Captain Jerk 1 episode, 1987
- Donna LaBrie
- Â Mary 1 episode, 1987
- Mary Jo Catlett
- Â Betty 1 episode, 1981
- Julie Anne Haddock
- Â Silver Slipper President 1 episode, 1981
- Howard Platt
- Â Gus Lambert 1 episode, 1981
- Helen Hunt
- Â Valerie 1 episode, 1982
- Alice Ghostley
- Â Mrs. Falconberg 1 episode, 1982
- Dennis Burkley
- Â Dr. George Avery 1 episode, 1982
- Alexa Kenin
- Â C.C. 1 episode, 1982
- Loren Lester
- Â Arnie 1 episode, 1982
- Ben Powers
- Â Tony 1 episode, 1982
- Hank Rolike
- Â Rev. Harper 1 episode, 1982
- Scott Strader
- Â Steve 1 episode, 1982
- Dana Gladstone
- Â Burglar #1 1 episode, 1982
- Robert Costanzo
- Â Mr. Brandt 1 episode, 1983
- The Pointer Sisters
- Â The Doo-Wop Girls 1 episode, 1983
- Tony Randall
- Â Tony Randall 1 episode, 1984
- Sharon Spelman
- Â Margaret Kanisky 1 episode, 1984
- Rick Lohman
- Â Warren Sandler 1 episode, 1985
- Ernie Hudson
- Â Prince 1 episode, 1987
- Art LaFleur
- Â Mr. Hamilton 1 episode, 1987
- Bill Henderson
- Â Ernie 1 episode, 1987
- Danny Glover
- Â Bill 1 episode, 1981
- Ray Vitte
- Â Ken 1 episode, 1981
- Mike Darnell
- Â George 1 episode, 1981
- Richard Beauchamp
- Â Raoul 1 episode, 1981
- Robert Miller Driscoll
- Â Mr. Meyer 1 episode, 1981
- Mallie Jackson
- Â Babs Pasternak 1 episode, 1981
- Liz Sheridan
- Â Nurse Whales 1 episode, 1982
- Eugene Roche
- Â Officer Jerry 1 episode, 1982
- John P. Navin Jr.
- Â Scotty Sherman 1 episode, 1982
- Elvia Allman
- Â Grandma Kanisky 1 episode, 1982
- Paul Regina
- Â Jonathan 1 episode, 1982
- Elizabeth Kerr
- Â Grandma Kanisky 1 episode, 1982
- Madison Arnold
- Â Burglar #2 1 episode, 1982
- William Larsen
- Â The Judge 1 episode, 1982
- Jim Gatherum
- Â Boy #1 1 episode, 1982
- Don Rickles
- Â Max 1 episode, 1983
- Alan Oppenheimer
- Â Mr. Daniels 1 episode, 1983
- Deborah Pratt
- Â Vanessa 1 episode, 1983
- Lois De Banzie
- Â Mother 1 episode, 1983
- Lance E. Nichols
- Â Vampire 1 episode, 1983
- George Kirby
- Â Mayor Hopkins 1 episode, 1983
- Gwen Verdon
- Â Lily 1 episode, 1984
- Rebecca Balding
- Â Wendy 1 episode, 1984
- Ed Koch
- Â Mayor Ed Koch 1 episode, 1984
- Phyllis Frelich
- Â Martha 1 episode, 1985
- Paul Gleason
- Â Mr. Kimball 1 episode, 1986
- Tom Wright
- Â Construction Worker 1 episode, 1987
- Patrick Cronin
- Â Mr. Gronimeyer 1 episode, 1987
- Helen Page Camp
- Â Mrs. Bennett 1 episode, 1987
- Haskell V. Anderson III
- Â Chauffer 1 episode, 1987
- Ralph Wilcox
- Â Ray 1 episode, 1981
- Kelly Ann Conn
- Â A Silver Slipper 1 episode, 1981
- Alan Stock
- Â The Robber 1 episode, 1981
- Michael A. Salcido
- Â The Maitre'd 1 episode, 1981
- Anthony Battelle
- Â Delivery Man 1 episode, 1981
- Crystal Bernard
- Â Kelly 1 episode, 1982
- Eliza Roberts
- Â Applicant #2 1 episode, 1982
- Florence Halop
- Â Mrs. Falkenberg 1 episode, 1982
- Thomas Byrd
- Â Dave 1 episode, 1982
- James Mendenhall
- Â The Doctor 1 episode, 1982
- Mark Harrison
- Â Patrolman #1 1 episode, 1982
- Edward Rayden
- Â Boy #2 1 episode, 1982
- Robyn Hastings
- Â Marie 1 episode, 1982
- Michael Dudikoff
- Â Greg Hartman 1 episode, 1983
- Thomas Callaway
- Â Michael 1 episode, 1983
- Andy Gibb
- Â Andy Gibb 1 episode, 1983
- F. William Parker
- Â Defense Attorney 1 episode, 1983
- Eugenia Wright
- Â Saniation Dept. Lady 1 episode, 1983
- LaShana Dendy
- Â Danny 1 episode, 1983
- Helen Rubio
- Â Mrs. Lopez 1 episode, 1983
- William Zabka
- Â Jeffrey 1 episode, 1984
- Ray Walston
- Â Andy 1 episode, 1984
- Bumper Robinson
- Â Boomer 1 episode, 1984
- Milton Berle
- Â Leopold 1 episode, 1984
- Ray Parker Jr.
- Â Ray Parker Jr. 1 episode, 1984
- Ken Berry
- Â Cute Dave 1 episode, 1985
- Timothy Brown
- Â William Frazier 1 episode, 1985
- Ebonie Smith
- Â Pam 1 episode, 1985
- Rob Steinberg
- Â Mr. Kirk 1 episode, 1985
- Sydney Goldsmith
- Â Jacki 1 episode, 1985
- Harry Basil
- Â Nicky Pappalardo 1 episode, 1986
- Jenny Beck
- Â Molly Hamilton 1 episode, 1987
- Diana Brookes
- Â Blonde 1 episode, 1987
- Lou Cutell
- Â The Druggist 1 episode, 1981
- David Kaufman
- Â Boy #3 1 episode, 1982
- Michael DeLano
- Â Vince 1 episode, 1982
- Michael O'Leary
- Â Todd 1 episode, 1982
- Lisa Antille
- Â Missy 1 episode, 1982
- Merlin Marston
- Â Patrolman #2 1 episode, 1982
- Bob Bigelow
- Â Man #2 1 episode, 1982
- Frantz Turner
- Â Wilson Brown 1 episode, 1983
- Kay Dingle
- Â Fainting Bank Customer 1 episode, 1983
- Barbara Hamilton
- Â Lady Shopper 1 episode, 1983
- Sumant
- Â Dr. Singh 1 episode, 1983
- Dennis Haysbert
- Â Rev. Winfield 1 episode, 1984
- Whitney Houston
- Â Rita 1 episode, 1984
- Pat Sajak
- Â Pat Sajak 1 episode, 1984
- Whitman Mayo
- Â Papa Jack Jenkins 1 episode, 1984
- Candi Milo
- Â Leslie 1 episode, 1984
- Peter Iacangelo
- Â Mr. Brown 1 episode, 1984
- Janice Kent
- Â Mrs. Piper 1 episode, 1984
- Abraham Alvarez
- Â Mr. Gonzalez 1 episode, 1984
- Gary Bayer
- Â Doctor 1 episode, 1984
- Jim Boyle
- Â Rick 1 episode, 1984
- Gloria Gifford
- Â Marilyn Wallace 1 episode, 1985
- William Lanteau
- Â Mr. Harris 1 episode, 1985
- Gerald Berns
- Â Man at the Bus Stop 1 episode, 1985
- Tim Haldeman
- Â Dr. Megway 1 episode, 1985
- Michelle Poulin
- Â Saleslady 1 episode, 1985
- Brian Backer
- Â Tyler 1 episode, 1986
- John Ingle
- Â Mr. Randall 1 episode, 1986
- Jane Galloway
- Â Sally Parsons 1 episode, 1986
- Gary Hudson
- Â Rudy 1 episode, 1987
- Niles Brewster
- Â Male Customer 1 episode, 1987
- Johnny Brown
- Â Rev. Digby 1 episode, 1982
- Renny Temple
- Â Arresting Officer 1 episode, 1982
- Fred Franklyn
- Â Charles Foster 1 episode, 1982
- Miriam Flynn
- Â Mrs. Brandt 1 episode, 1983
- Charles Cooper
- Â Customer 1 episode, 1983
- Laurie Rose
- Â Belly Dancer 1 episode, 1983
- James Cromwell
- Â Russell Cosgrove 1 episode, 1984
- Mykelti Williamson
- Â Waiter 1 episode, 1984
- Marcia Rodd
- Â Officer Dwyer 1 episode, 1984
- Hal Williams
- Â Dr. Phil Gray 1 episode, 1984
- Ola Ray
- Â Deanna 1 episode, 1984
- J.A. Preston
- Â Preston Pomeroy 1 episode, 1984
- Basil Hoffman
- Â Mr. Fuller 1 episode, 1984
- Rod Colbin
- Â Dr. Kessler 1 episode, 1984
- Nicole Rosselle
- Â Young Katie 1 episode, 1984
- Sammy Davis Jr.
- Â Albert / ... 1 episode, 1985
- Sheila Frazier
- Â Yvonne Anderson 1 episode, 1985
- Steven Williams
- Â Harvey 1 episode, 1986
- Jack Colvin
- Â Dr. Raymond Michaelson 1 episode, 1986
- Al Fann
- Â Ben Guthrie 1 episode, 1986
- Walter Mathews
- Â Policeman Carlotti 1 episode, 1986
- Reuven Bar-Yotam
- Â Mr. Pappalardo 1 episode, 1986
- Michael Korn
- Â Walter 1 episode, 1986
- Fred Holliday
- Â Lottery Host 1 episode, 1987
- Susan Wolf
- Â Receptionist 1 episode, 1987
- Beverly Stone
- Â Female Customer 1 episode, 1987
- Nigel Bullard
- Â Man in the Bar 1 episode, 1981
- Madison Mason
- Â News Anchor 1 episode, 1982
- Jeffrey Wheat
- Â Cameraman 1 episode, 1982
- Donnelly Rhodes
- Â Mayor 1 episode, 1983
- Jack Manning
- Â Security Guard 1 episode, 1983
- John Medici
- Â Officer 1 episode, 1983
- Rob Berger
- Â Pete 1 episode, 1983
- Jack Dodson
- Â Principal Smythe 1 episode, 1984
- K.C. Martel
- Â Danny Maloney 1 episode, 1984
- Keri Houlihan
- Â Young Julie 1 episode, 1984
- Joe Gieb
- Â Mr. Baker 1 episode, 1984
- Justin Lord
- Â Dr. Fred Robinson 1 episode, 1984
- Gary Lee Davis
- Â Moose Murphy 1 episode, 1984
- Kim Hamilton
- Â Della 1 episode, 1985
- Charles Walker
- Â Pervis 1 episode, 1985
- John Welsh
- Â Man 1 episode, 1985
- Bennet Guillory
- Â Steven Marken 1 episode, 1986
- Susan Bugg
- Â Helen 1 episode, 1986
- Marianne Muellerleile
- Â Betty 1 episode, 1982
- Richard Paul
- Â Stanley Nichols 1 episode, 1982
- Patrick Henderson
- Â Patrick Henderson 1 episode, 1982
- Gretchen Wyler
- Â Aunt Blanche 1 episode, 1983
- Ken Olfson
- Â Jason Swinborn III 1 episode, 1983
- Sheila Rogers
- Â Woman #1 1 episode, 1983
- Joyce Gittlin
- Â Bridesmaid #1 1 episode, 1983
- Donna Wilkes
- Â Gina 1 episode, 1984
- Dorothy Meyer
- Â Sarah Banks 1 episode, 1984
- Kathy Gieb
- Â Mrs. Baker 1 episode, 1984
- Jeanna Barron
- Â Young Samantha 1 episode, 1984
- Nabil Ashour
- Â Kid 1 episode, 1986
- Cynthia Szigeti
- Â Amy 1 episode, 1982
- Bert Rosario
-  José 1 episode, 1983
- Celia Wellman
- Â Bridesmaid #2 1 episode, 1983
- Peggy McCay
- Â Robin Thornton 1 episode, 1984
- Kathryn Reynolds
- Â Mickey Hightower 1 episode, 1984
- Marii Mak
- Â Mary Lou Fong 1 episode, 1985
- Joseph Baham
- Â Kid 1 episode, 1986
- Julia DeVito
- Â Julia 1 episode, 1984
- Mari Falcone
- Â Piano Player 1 episode, 1984
- Fred D. Scott
- Â Minister 1 episode, 1985
- Elizabeth Berkley
- Â Kid 1 episode, 1986
- Kristy Chan
- Â Kid 1 episode, 1986
- Vanna White
- Â Vanna White 1 episode, 1984
- Ken Page
- Â Kenneth Wilson 1 episode, 1984
- Paul Bahn
- Â Musician 1 episode, 1985
- Adrian Delagarza
- Â Kid 1 episode, 1986
- Marcia Wallace
- Â Hilda 1 episode, 1983
- Eileen Saki
- Â Karen Chang 1 episode, 1984
- Jim Furmston
- Â Musician 1 episode, 1985
- Todd Garner
- Â Kid 1 episode, 1986
- Randy Mitchell
- Â Musician 1 episode, 1985
- Susan Guzman
- Â Kid 1 episode, 1986
- Keith Nelson
- Â Musician 1 episode, 1985
- Mike Lawrence
- Â Kid 1 episode, 1986
- Snooki Young
- Â Musician 1 episode, 1985
- Alisa Mast
- Â Kid 1 episode, 1986
- Katina Morris
- Â Kid 1 episode, 1986
- Steve Real
- Â Kid 1 episode, 1986
- Jennifer Ruiz
- Â Kid 1 episode, 1986
- Kyiana Walker
- Â Kid 1 episode, 1986
- Peter Aguilar
- Â Student Protester 1 episode, 1984
- Marsha Clark
- Â Loan Officer 1 episode, 1986
- Kathy Wagner
- Â Young Julie (uncredited) 1 episode, 1981
- Jo de Winter
- Â Woman #2 (uncredited) 1 episode, 1983
- Carol Sutton
- Â Stewardess (uncredited) 1 episode, 1984
- Ellis Marsalis
- Â Gospel Pianist (uncredited) 1 episode, 1984
- Shelly Markham
- Â Piano Player (uncredited) 1 episode, 1985