- Clint Eastwood
- Monco
- Lee Van Cleef
- Col. Douglas Mortimer
- Gian Maria Volontè
- El Indio (The Indian)
- Mara Krupp
- Mary - Hotel Manager's Beautiful Wife
- Luigi Pistilli
- Groggy, Member of Indio's Gang
- Klaus Kinski
- Juan Wild - The Hunchback
- Luis Rodríguez
- Manuel (Member of Indio's Gang)
- Benito Stefanelli
- Luke 'Hughie'
- Panos Papadopulos
- Sancho Perez, Member of Indio's Gang
- Aldo Sambrell
- Cuchillio
- Roberto Camardiel
- Tucumcari station clerk
- Joseph Egger
- Old Prophet
- Tomás Blanco
- Tucumcari sheriff
- Lorenzo Robledo
- Tomaso, Indio's Traitor
- Dante Maggio
- Carpenter in cell with El Indio
- Sergio Mendizábal
- Tucumcari bank manager
- Diana Rabito
- Callaway's beautiful girl in tub
- Giovanni Tarallo
- Santa Cruz telegraphist
- Mario Meniconi
- Train Conductor
- Mario Brega
- Nino, Member of Indio's Gang
- Werner Abrolat
- Slim, Member of Indio's Gang
- Román Ariznavarreta
- Half-Shaved Bounty Hunter
- Joseph Bradley
- El Paso Tavern Keeper
- Frank Braña
- Blackie, Member of Indio's Gang
- José Canalejas
- Chico, Member of Indio's Gang
- Rosemary Dexter
- Mortimer's Sister
- Fernando Di Leo
- Cigar Smoking Card Player
- Diana Faenza
- Tomaso's Wife
- Enrique GarcÃa Santiago
- Miguel - Member of Indio's Gang
- Eduardo García
- Member of Indio's Gang
- Maurizio Graf
- The Balladeer
- Jesús Guzmán
- Carpetbagger on Train
- Peter Lee Lawrence
- Mortimer's Brother-in-Law
- Francesca Leone
- Tomaso's Baby
- Sergio Leone
- Whistling Bounty Hunter
- Rafael López
- (uncredited)
- José Marco
- 'Baby' Red Cavanaugh
- Shelly Martin
- Tomaso's Wife
- Antonio Molino Rojo
- Frisco, Member of Indio's Gang
- Antonio Montoya
- Paco
- José Félix Montoya
- (uncredited)
- Guillermo Méndez
- White Rocks Sheriff
- Nazzareno Natale
- Paco - Member of Indio's Gang
- Enrique Navarro
- Sherrif of Tucumcari
- Ricardo Palacios
- Tucumcari Saloon Keeper
- Antonio Palombi
- Bartender
- Aldo Ricci
- (uncredited)
- Antoñito Ruiz
- Fernando
- Enrique Santiago
- Miguel, Member of Indio's Gang
- Carlo Simi
- El Paso Bank Manager
- José Terrón
- Guy Calloway, Mortimer's 1st Criminal
- Edmondo Tieghi
- 2nd Agua Caliente Villager watching Monco
- Kurt Zips
- Hotel Manager