- Matt Furie
- Self - Artist, Creator of Pepe the Frog
- Aiyana Udesen
- Self - Artist, Matt's Partner
- Chris Sullivan
- Self - Matt & Aiyana's Housemate
- Johnny Ryan
- Self - Typical Cartoonist, Angry Youth Comix
- Lisa Hanawalt
- Self - Artist & Writer, Tuca & Bertie, BoJack Horseman
- Emily Heller
- Self - Comedian and TV Writer
- Susan Blackmore
- Self - Psychologist and Memetist, Author, The Meme Machine
- Dale Beran
- Self - Artist & Writer, Author, 4chan: The Skeleton Key to the Rise of Trump
- Pizza
- Self - 4channer
- Mills
- Self - 4channer
- Peder Riis
- Self - Cartoonist
- Aleks Krotoski
- Self - Psychologist & Journalist, Author, Untangling thes Web
- Ursala Furie
- Self - Matt and Aiyana's Daughter
- Brian McMullen
- Self - Editor & Art Director, MeSweeney's
- Joel Finkelstein
- Self - Director, Network Contagion Research Institute, Princeton University
- Aaron Sankin
- Self - Journalist
- Matt Braynard
- Self - Executive Director, Look Ahead America
- John Michael Greer
- Self - Occultist and Scholar, Author, Encyclopedia of Natural Magic
- Skinner
- Self - Artist
- Adam Serwer
- Self - Staff Writer, The Atlantic
- Rachael Finley
- Self - Founder, Teenage Clothing
- Hampton Boyer
- Self - Artist & Curator
- Kevin Sukho Lee
- Self - Antist & Matt Funie Colleeton
- Clint Smith
- Self - Thrift Store Co-Worker
- Peter Kell
- Self - Crypto Currency Trader
- Pepe Cash Millionaire
- Self - Crypto Currency Trader
- Jeremy Blackburn
- Self - Computer Scientist
- Louis Tompros
- Self - Copyright Attorney, WilmerHale
- Stephanie Lin
- Self - Copyright Attorney, WilmerHale
- Oren Segal
- Self - Director, Center of Extremism Anti-Defamation League
- Robert Barnes
- Self - Attorney, InfoWars
- Samantha Bee
- Self - Host, Full Frontal With Samantha Bee
- Hillary Clinton
- Self - 2016 Democratic Presidential Candidate
- Alex Jones
- Self - Host, InfoWars
- Rachel Maddow
- Self - Host, The Rachel Maddow Show
- Nicki Minaj
- Self - Pepe the Frog Meme Poster
- Max Misch
- Self - White Nationalist
- Kiah Morris
- Self - Former Member of the Vermont House of Representatives
- Logan Paul
- Self
- Katy Perry
- Self - Pepe the Frog Meme Poster
- Christopher Poole
- Self - Founder, 4chan.org
- Marc Randazza
- Self - Attorney, InfoWars
- Keanu Reeves
- Self - 'Sad Keanu'
- Elliot Rodger
- Self - Mass Shooter
- Richard Spencer
- Self - Alt Right Leader & White Nationalist
- Donald Trump
- Self - 45th President of the United States
