- Joaquin Phoenix
- John Callahan
- Jonah Hill
- Donny
- Rooney Mara
- Annu
- Jack Black
- Dexter
- Tony Greenhand
- Tim
- Beth Ditto
- Reba
- Mark Webber
- Mike
- Ronnie Adrian
- Martingale
- Kim Gordon
- Corky
- Udo Kier
- Hans
- Carrie Brownstein
- Suzanne
- Ethan Tindukasiri
- Skateboarder #1
- Sunny Suljic
- Skateboarder #2
- Cree Kawa
- Skateboarder #3
- Nolan Gross
- Skateboarder #4
- Leo Phoenix
- Skateboarder #5
- Emilio Rivera
- Jesus Alvarado
- Ken Tatafu
- Bill in Wheelchair
- Angelique Rivera
- Terry Alvarado
- Rebecca Rittenhouse
- Bonnie
- Anne Lane
- Virginia
- Jessica Jade Andres
- Cindy
- Torian Miller
- Car Attendant
- Rebecca Field
- Margie Bighew
- Olivia Hamilton
- Nurse Lilly
- Peter Banifaz
- Doctor Mirione
- Alexandra W.B. Malick
- Older Nurse
- Kyle Dunnigan
- Ward Doctor
- Santina Muha
- Debbie
- Daniella Garcia
- Nurse at Rancho Hospital
- Christopher Thornton
- Charles-Marie
- Edgar Momplaisir
- Roger Fairies
- Matt Bennett
- Editor #2
- Joe Baken
- Editor #3
- Ron Perkins
- Mr. Katz
- Heather Matarazzo
- Shannon
- Michael Chow
- PSU Teacher
- Ryan Meharry
- Police Office #1
- Cathy Fielding
- Bakery Woman
- John Bishop
- Cowboy Wino
- Ronnie Clark
- Wino One
- Jonathan Erickson Eisley
- Junior Wino
- Betsy Sodaro
- Powell's Information Person
- Jedediah Jones
- Felix-AA Member #1
- Lou Wilson
- Joseph-AA Member #2
- John Balma
- Department Store Man
- Ayden Mayeri
- Brenda
- Nicholas Rutherford
- Drinker
- Ramy Youssef
- Drinker
- Robby Rasmussen
- Levon - Man on Bike
- Maxwele D'Angelo
- Cabbie
- Helen Slayton-Hughes
- Woman on Bus
- Bruce Richmond Chambers
- School Teacher
- Ethan Michael Mora
- Young John Callahan
- Kade Martinez
- Young John's Brother #1
- Brady Nuthall
- Young John's Brother #2
- Isabella Baltodano
- Young John's Sister
- Mireille Enos
- John's Ghost Mom
- Erica Jade Goldsmith
- Cocktail Waitress
- Suzy Sincock
- Liquor Store Owner
- Connor Skific
- Cowboy
- Sheila Brown
- Rancho Therapist
- Jeffrey Gamble
- John's Roommate - Jesus
- Scott Alan Berk
- Police Officer #2
- Sheldon Vila Widuch
- Long Beach Nurse
- Dion Earl
- Physical Therapist
- Jim Kwiatkowski
- Orderly
- Kelli McNeil
- Woman with Dog
- Gus Van Sant
- Willamette Week Editor
- Jahmin Assa
- Jahmin
- Toni Charline
- Wino #2
- Austin Durden
- Gymnast
- LynNita Ellis
- Nun
- Jake Erringer
- Cowboy
- Lee John Gilligan
- Attendee
- Fatimah Hassan
- Driver / Pedestrian (uncredited)
- Dylan James Holt
- Self
- Richard Allan Jones
- Wheelchair Vet in Rehab
- Ivan Katz
- Homeless Person
- Omar Kenawi
- AA Member
- Tatiana Lee
- Rancho Patient
- David B. Levinson
- 12 Steps Man
- Sergio Martinez
- Sous Chef / Alfonso (uncredited)
- Jaret Martino
- Booth Operator
- Pat-Ric McCaffery
- Singing, Drunken Irish Dude
- George Todd McLachlan
- Beach boy
- Aleu Moana
- Celeste
- James Quach
- Japanese Man
- Paul Mitchell Rosenblum
- AA Member
- Sandra Rosko
- Party Girl
- Darrion Scoggins
- Party Attendee
- Amir Talai
- Night Doctor
- Jessica Uhler
- Wino #3
- Zack Whyel
- Sex Ed Family Member
- Alex Winterwood
- Attendee
- Jeremy Wojchihosky
- Portland Cashier
- Steve Zissis
- Elias
