- Jane Winton
- Donna Isobel
- John Roche
- Leandro
- Warner Oland
- Cesare Borgia
- Estelle Taylor
- Lucrezia Borgia
- Montagu Love
- Count Giano Donati
- Josef Swickard
- Duke Della Varnese
- Willard Louis
- Pedrillo
- Nigel De Brulier
- Marchese Rinaldo
- Hedda Hopper
- Marchesia Rinaldo
- Myrna Loy
- Mai - Lady in Waiting
- Mary Astor
- Adriana della Varnese
- John Barrymore
- Don Jose de Marana / Don Juan de Marana
- Sam Appel
- Reveler at Juan's
- Lionel Braham
- Duke Margoni
- Helene Costello
- Rena - Adriana's Maid
- Helena D'Algy
- Donna Elvira
- Marion Morgan Dancers
- Bacchanalian Revelers
- Yvonne Day
- Don Juan - at age 5
- Philippe De Lacy
- Don Juan - at age 10
- Emily Fitzroy
- The Dowager
- John George
- Hunchback
- Gibson Gowland
- Gentleman of Rome
- Phyllis Haver
- Imperia
- Sheldon Lewis
- Gentleman of Rome
- June Marlowe
- Trusia
- Scotty Mattraw
- Man with Dancing Girls
- Anne Sheridan
- Bit Part
- Dick Sutherland
- Gentleman of Rome
- Harry Tenbrook
- Borgia guard
- Gustav von Seyffertitz
- Neri - the Alchemist
- Helen Lee Worthing
- Eleanora
