- Dan Aykroyd
- Clifford Skridlow / Doctor Detroit
- Howard Hesseman
- Smooth Walker
- Donna Dixon
- Monica McNeil
- Lydia Lei
- Jasmine Wu
- T.K. Carter
- Diavolo Washington
- Lynn Whitfield
- Thelma Cleland
- Fran Drescher
- Karen Blittstein
- John A. Maloney
- Commodore
- Pershing P. Anderson
- Stretch
- William Munchow
- Professor Artel
- Ed Meekin
- Professor Durant
- Hank Salas
- Johnny
- Rudolph Kovar
- Carson
- Kate Murtagh
- Mom
- Peter Elbling
- Guptor
- George Furth
- Arthur Skridlow
- Nan Martin
- Margaret Skridlow
- Peter Aykroyd
- Mr. Frankman
- Glenne Headly
- Miss Debbylike
- Annabel Armour
- Airline Clerk
- Robert Cornthwaite
- Professor Blount
- Thomas O. Erhart Jr.
- Dean Swift
- Parley Baer
- Judge
- Oliver Clark
- Shaky Alcoholic Lawyer
- Ben Kronen
- Bailiff
- Lance Kinsey
- Street Dude
- Lynda Aldon
- Dream Girl
- Carla Barbour
- Dream Girl
- Sue Bowser
- Dream Girl
- Tamara Clarrett
- Dream Girl
- Deirdre L. Cowden
- Dream Girl
- Deborah Koppel
- Dream Girl
- Deanna Joy
- Dream Girl
- Toni Naples
- Dream Girl
- Roni Michelle
- Dream Girl
- Laurie Senit
- Dream Girl
- Andrew Duggan
- Harmon Rousehorn
- Robert Swan
- Seedy Biker
- Frank Rice
- Cop #1
- Mike Hagerty
- Cop #2
- Eugene Pressman
- Professor Fulsom
- Victoria Brown
- Mrs. Fulsom
- Ben Frommer
- Faculty Member
- John Kapelos
- Rush Street Dude
- James Spinks
- Rush Street Dude
- James Brown
- Bandleader
- Clyde J. Barrett
- Players Ball Dancer
- Brad Barrios
- Players Ball Dancer
- Derrick Brice
- Players Ball Dancer
- Patricia Ann Douglas
- Players Ball Dancer
- Sonja Haney
- Players Ball Dancer
- Bruce Heath
- Players Ball Dancer
- Carlton Johnson
- Players Ball Dancer
- Ercelle Johnson
- Players Ball Dancer
- Keny Long
- Players Ball Dancer
- Sioux Marcelli
- Players Ball Dancer
- Ade Small
- Players Ball Dancer
- Dona Davis-Steckling
- Players Ball Dancer
- Blackie Dammett
- Eddie Four Eyes
- Vincent J. Isaac
- St. Louis Louis
- Steven Williams
- Junior Sweet
- Cheryl Carter
- Charlene
- Diane Robin
- Rae Ann
- Manny Weltman
- Robbi Miller
- Bill Baker
- Waiter
- Robert Buckingham
- Party Guest
- Ken Hudson Campbell
- Guy with Car
- Marilyn Corwin
- Dancer
- David Eisen
- Pimp
- George Golden
- Guest
- Bob Harks
- Party Guest
- Bud Hazlett
- Courtroom Spectator
- David Lautrec
- Party Guest
- Danny Nero
- Attending Physician
- Monty O'Grady
- Courtroom Spectator
- Chuck Richter
- Limo Driver
- Alan Ruck
- Student
- Glenn R. Schorsch
- Mom's Henchman #3
- Paul Van
- Party Guest
- Marquerita Wallace
- (uncredited)
- Tom Willett
- Restaurant Patron