- Zach Callison
- Billy Batson (segment "The Return of Black Adam")
- James Garner
- Shazam (segment "The Return of Black Adam")
- Josh Keaton
- Punk (segment "The Return of Black Adam")
- Danica McKellar
- Sally (segment "The Return of Black Adam")
- George Newbern
- Superman / Clark Kent (segment "The Return of Black Adam") (voice)
- Jerry O'Connell
- Captain Marvel (segment "The Return of Black Adam")
- Kevin Michael Richardson
- Mister Tawky Tawny (segment "The Return of Black Adam")
- Arnold Vosloo
- Black Adam (segment "The Return of Black Adam")
- Gary Cole
- Jim Corrigan / The Spectre (segment "The Spectre") (voice)
- Alyssa Milano
- Aimee Brenner (segment "The Spectre")
- Jeff Bennett
- Foster Brenner / Peter McCoy / Flemming (segment "The Spectre") (voice)
- Rob Paulsen
- Drew Flynn / Lt. Brice / Deandre (segment "The Spectre") (voice)
- Jon Polito
- Police Captain (segment "The Spectre")
- Malcolm McDowell
- Merlyn the Magnificent (segment "Green Arrow")
- Neal McDonough
- Green Arrow / Oliver Queen (segment "Green Arrow") (voice)
- Steve Blum
- Count Vertigo (segment "Green Arrow")
- Grey Griffin
- Black Canary (segment "Green Arrow")
- John DiMaggio
- Merc (segment "Green Arrow")
- Ariel Winter
- Princess Perdita (segment "Green Arrow")
- Thomas Jane
- Jonah Hex (segment "Jonah Hex")
- Linda Hamilton
- Madame Lorraine (segment "Jonah Hex")
- Jason Marsden
- Young Man / Bartender (segment "Jonah Hex") (voice)
- Michael Rooker
- Red Doc (segment "Jonah Hex")
- Michelle Trachtenberg
- Bar Girl (segment "Jonah Hex")
