- Edna May Oliver
- Aunt Betsey
- Elizabeth Allan
- Mrs. Copperfield
- Jessie Ralph
- Nurse Peggotty
- Harry Beresford
- Dr. Chillip
- Freddie Bartholomew
- David, the Child
- Hugh Walpole
- The Vicar
- Basil Rathbone
- Mr. Murdstone
- Herbert Mundin
- Barkis
- John Buckler
- Ham
- Fay Chaldecott
- Little Em'ly, the Child
- Una O'Connor
- Mrs. Gummidge
- Lionel Barrymore
- Dan Peggotty
- Violet Kemble Cooper
- Jane Murdstone
- Elsa Lanchester
- Clickett
- Jean Cadell
- Mrs. Micawber
- W.C. Fields
- Micawber
- Lennox Pawle
- Mr. Dick
- Renee Gadd
- Janet
- Roland Young
- Uriah Heep
- Lewis Stone
- Mr. Wickfield
- Marilyn Knowlden
- Agnes, the Child
- Frank Lawton
- David, the Man
- Madge Evans
- Agnes
- Hugh Williams
- Steerforth
- Maureen O'Sullivan
- Dora
- Florine McKinney
- Little Em'ly, the Woman
- Ivan F. Simpson
- Littimer
- Mabel Colcord
- Mary Ann
- Marion Ballou
- Dora's Aunt
- Lionel Belmore
- Old Bailey Warden
- Bobby Callahan
- (uncredited)
- Dennis Chaldecott
- Micawber's Son
- E.E. Clive
- Sheriff's Man
- Eileen Ingles
- David Copperfield as an Infant
- Norman Phillips Jr.
- Mealy
- Sonny Ray
- Mickey Walker
- Margaret Seddon
- Dora's Aunt
- Yorke Sherwood
- Mr. Quinion
- Arthur Treacher
- Donkey Man
