- Jack Lemmon
- Jake Tremont
- Ted Danson
- John Tremont
- Olympia Dukakis
- Bette Tremont
- Kathy Baker
- Annie
- Kevin Spacey
- Mario
- Ethan Hawke
- Billy
- Zakes Mokae
- Dr. Chad
- J.T. Walsh
- Dr. Santana
- Peter Michael Goetz
- Dr. Ethridge
- John Apicella
- Dr. Delibro
- Richard McGonagle
- Victor Walton
- Bill Morey
- Hal McCarthy
- Mary Fogarty
- Gloria McCarthy
- Art Frankel
- DMV Instructor
- Ray Girardin
- Butcher
- Vickilyn Reynolds
- CCU Nurse
- Edith Fields
- Jake's Nurse
- Takayo Fischer
- Jake's Nurse
- Andi Chapman
- Jake's Nurse
- Erin Strom
- Nurse
- Lisa Rae
- Nurse
- Emily Kuroda
- Vicki
- Jimmy Higa
- Chris
- Gregory Itzin
- Ralph Kramer
- Richard Fiske
- Bingo Caller
- Tony Kienitz
- Bank Executive
- Terry Wills
- Dry Cleaner
- Patti Arpaia
- Receptionist
- Donna Guidry
- Surprised Neighbor
- Jan Munroe
- Corporate Employee
- Nancy Paul
- Corporate Employee
- Charles Stransky
- Corporate Employee
- Patrick Massett
- Corporate Employee
- Chris Lemmon
- Young Jake
- Gina Raymond
- Young Bette
- Justin Peterson
- Young John
- Sprague Grayden
- Young Annie
- Lucas Hall
- Hank
- Katie Kissell
- Lizbeth
- Lewis Arquette
- (voice)
- Richard Brestoff
- (voice)
- Ed Cook
- (voice) (as Edwin Cook)
- Ira Miller
- (voice)
- Bridget Sienna
- (voice)
- Ruth Silveira
- (voice)
- Gregory Snegoff
- (voice)
- Gigi Vorgan
- (voice)
- Bob Harks
- Shopper
- Douglas Maida
- Surprised Neighbor
- Laura Walsh
- Bar Patron
