- David Mattey
- Toxic Avenger / Noxious Offender / Chester's Fellatio Customer
- Clyde Lewis
- Toxie
- Heidi Sjursen
- Sarah / Claire
- Paul Kyrmse
- Sgt. Kabukiman / Evil Kabukiman
- Joe Fleishaker
- Chester / Lardass
- Dan Snow
- Sgt. Kazinski
- Michael Budinger
- Tito
- Lisa Terezakis
- Sweetie Honey
- Barry Brisco
- Pompey
- Debbie Rochon
- Ms. Weiner
- Ron Jeremy
- Mayor Goldberg
- Corey Feldman
- Sarah's Gynecologist
- Trent Haaga
- Tex Diaper
- Mark Torgl
- Evil Melvin
- Rick Collins
- Amortville Police Chief
- Mitch Cohen
- Lucifer (Dragging Redneck #1)
- Lisa Gaye
- Abortion Counselor
- Bill Weeden
- Abortion Doctor
- Stan Lee
- Prologue / Epilogue Narrator (voice) (as Peter Parker)
- Jon Avner
- Tromaville Chief Newman
- James Gunn
- Doctor Flem Hocking
- Carla Pivonski
- Bikini Anchor Samantha Chambers
- Hank the Angry Drunken Dwarf
- God
- Al Goldstein
- Mayor Goldberg's Press Secretary
- Taylor Mead
- Award Presenter
- Dick Kulpa
- Weekly World News Reporter
- Tromelissa Saytar
- Lesbian Art Student
- Joe Floccari
- Festive Wheelchair-Bound Special Student
- Chris Bagnall
- Lucky Retard Stud
- Meredith Conti
- Special Student
- Gregory Costello
- Special Student
- Monica Garrett
- Special Student
- Rob Grace
- Special Student
- Ben Friedman
- Special Student
- Edwin Hauge
- Special Student
- James Hepburn
- Special Student
- Steve Keener
- Special Student / Tromaville Nazi
- Katja Kurner
- Special Student
- Vincent Berrini
- Special Student
- James Ojala
- Special Student
- Doug Sakmann
- Special Student / Plastic Surgery Patient
- John Schmidt
- Special Student
- Tobias Suhm
- Special Student
- Eric Van Wagenen
- Special Student
- Yaniv Sharon
- Lex Diaper
- Caleb Emerson
- Dex Diaper
- Nicole Howe
- Diaper Mafia Temptress
- Bella Compagna
- Diaper Mafia Temptress (with Beautiful Breasts)
- Purple Pam
- Duel Gyno
- Andy Animal
- Death by Pencil in Eye
- Marcia Lynn
- Death by Overhead Toxie Hurl
- R.H. Bear
- Other Diaper Mafia Member
- Rich Preach
- Other Diaper Mafia Member
- John Fay
- Other Diaper Mafia Member
- Antonio Tomahawk
- Other Diaper Mafia Member
- Kevin Moriarty
- Other Diaper Mafia Member
- Christina Hibbs
- Bomb Voice
- Joseph Anthony
- Sara's Fantasy Toxie
- Jason Sklar
- Jason Diaz (Action News Anchor #1)
- Randy Sklar
- Jason Gonzales (Action News Anchor #2)
- Kevin 'Cappy' Kern
- Josh Levitsky
- Will Keenan
- Man Hit by Car
- Mike Butler
- News Producer
- Gabriel Friedman
- Josh Levitsky's Super-Hero Pal / Radio News Announcer / Tromaville Citizen
- Sean McGrath
- Josh Levitsky's Super-Hero Pal / Homosexual #2
- Heather Litteer
- Reporter #1
- Elizabeth Johnson
- Reporter #2 (Cindy Tata)
- Eric 'Zork' Alan
- Reporter #3
- Eric Dunlap
- Bucktooth Cop
- Andre Carrington
- Afro Cop
- Lewis Manalo
- Tromaville Policeman
- Patrick Gallanue
- Death by Throat Ripped Out
- Ken Squier
- Death by Tongue Ripped Out
- Nick Stevens
- Homosexual #1
- Olivia Scheck
- 12-Year-Old Girl
- Doris Troncillito
- Old Woman
- Melissa R. Bacelar
- Hocking's Nurse
- Julie Anderson
- Hocking's Nurse
- Julie Bunny
- Hocking's Nurse
- Olivier Tendon
- Dolphin Man / Kabukiman's Drinking Buddy
- Jarred Alterman
- Master-Bater
- Anthony Catanese
- Mad Cowboy
- Lauren Heather McMahon
- The Vibrator
- Terri Firmer
- Wet Lesbian / Topless Deaf Translator
- Jasi Cotton Lanier
- Wet Lesbian
- Matt Attenburg
- Angry Citizen
- Daniel Beckerman
- Angry Citizen
- Alex Brandt
- Angry Citizen
- Josh Darling
- Angry Citizen
- Ronni Thomas
- Angry Citizen
- Steve Debono
- Angry Citizen
- Justin Haberstaat
- Reporter
- Lemmy
- Good Lemmy / Bad Lemmy (as Lemmy Kilmeister)
- Greg Nolasco
- Dragging Redneck #2
- Janine de Boisblanc
- Plastique Palace Nurse
- Tom Fitzgerald
- Plastique Palace Assistant
- Geoff Mosher
- Fudgie
- Mark Blacklock
- English Dead Body
- Julie Strain
- Self - Facelift Death)
- Kevin Eastman
- Self - Breast Smoosh Death)
- Kathleen Wirt
- Julie Strain Double
- Crystal McCloud
- Nurse
- Alisa Christensen
- Woman who Falls from High Rock
- Erik Dage
- Internet Contest Winner (Death by Pole in Head)
- John Schnitzer
- Addtional Contest Winner / Bystander
- Stacy Burke
- Additional Contest Winner
- Lich Doan
- Additional Contest Winner
- Andrew Kirby
- Grotto Penis Boy
- Erik Wong
- Troma Team Player
- Hiliary Lazyan
- Troma Team Player
- Daniel Diaz
- Troma Team Player / Rollerblader
- Eric Waddell
- Troma Team Player
- Eli Roth
- Beautiful Young Boy
- Tiffany Shepis
- Beautiful Interpretative Dancer
- Andrew Lerner
- Death by Fist through Skull
- Robert Pusatere
- Dude Pushed into Pool / Bystander
- Tom Fulp
- Painter
- Carol Anne Allen
- Painting Appreciator
- Vince Matinelli
- Grotto Boy
- Stewart McKinlay
- Grotto Boy
- Kenny Deangelis
- Grotto Boy
- Neal Mahoney
- Grotto Boy
- Beverly Price-Fox
- Bystander
- Jan-Hendrik Hein
- Bystander
- Tyler Jacobson
- Bystander
- C.J. Johnson
- Bystander
- Den Shewman
- Bystander
- Melinda Bonini
- Glamorous Gyno-American
- Brandi Brandt
- Glamorous Gyno-American
- Neriah Davis
- Glamorous Gyno-American
- Deval Day
- Glamorous Gyno-American
- Allison Deck
- Glamorous Gyno-American
- Lunden De'Leon
- Glamorous Gyno-American
- Devin DeVasquez
- Glamorous Gyno-American
- Sally Jean Dolgin
- Glamorous Gyno-American
- Tracey Faithe
- Glamorous Gyno-American
- Gabrielle Friedgirl
- Glamorous Gyno-American
- Tracy Graham
- Glamorous Gyno-American
- Taimie Hannum
- Glamorous Gyno-American
- Elke Jeinsen
- Glamorous Gyno-American
- Echo Johnson
- Glamorous Gyno-American
- Joseph Karam
- Glamorous Gyno-American
- Lana Kinnear
- Glamorous Gyno-American
- Jessica Lee
- Glamorous Gyno-American
- Letitia Long
- Glamorous Gyno-American
- Nicole Malaichi
- Glamorous Gyno-American
- Jill St. Marks
- Glamorous Gyno-American
- Masuimi Max
- Glamorous Gyno-American
- Jacqueline Mines
- Glamorous Gyno-American
- Celeste Octavia
- Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)
- Estelle Reyna
- Glamorous Gyno-American
- Doria Rone
- Glamorous Gyno-American
- Stacey Rush
- Glamorous Gyno-American
- Sita Thompson
- Glamorous Gyno-American
- Petra Verkaik
- Glamorous Gyno-American
- Teresa Williams
- Glamorous Gyno-American
- Alison Grossman
- Abortion Protester
- Renee Scales
- Abortion Receptionist
- George Gatter
- Porno Set Crew
- Evan Meszaros
- Porno Set Crew
- Peter Matsoukas
- Porno Set Crew
- Tony Tuff
- Porn Set Crew
- Cat Sarrel
- Porno Set Crew
- Joanna Shattuck
- Porno Set Crew
- Haig Demarjian
- St. Peter
- Rusty Nails
- Kabukiman's Drinking Buddy
- Vincent Colombo
- Kabukiman's Drinking Buddy
- Steven A. Lasserson
- Nervous Doctor
- Eduardo Ivan Velilla
- Naked Old Guy
- Christine Richards
- Nazi Woman
- Florian Schura
- Tromaville Nazi #1
- Joe James
- Tromaville Nazi #2
- Joe Cortese
- Tromaville Nazi #3
- Brian McNulty
- Tromaville Nazi #4
- Morgan Henderson
- Tromaville Nazi #5
- Tony Nigro
- Tromaville Nazi #6
- R.J. Wafer
- Tromaville Nazi #7
- Paul Mastrella
- Doctor
- Jack Noonan
- Doctor
- Don May Jr.
- Hospital Worker
- Daniel Blanes
- Tromaville Nazi
- Brian Hathaway
- Tromaville Nazi
- Steve Hathaway
- Tromaville Nazi
- Jamaal Hynds
- Tromaville Nazi
- Mitch Cumstein
- Tromaville Nazi
- Matt Klan
- Tromaville Nazi
- April Philip
- Tromaville Nazi
- Theo Philip
- Tromaville Nazi
- Roman Pietrs
- Tromaville Nazi
- Marcy Goldberg
- Tromaville Nazi
- Bradley T. Watson
- Tromaville Nazi
- Terry Shane
- Tromaville Nazi
- Robert Simmons
- Tromaville Nazi
- John Vaca
- Tromaville Nazi
- Matt Wasowski
- Tromaville Nazi
- Ed Ringwood
- Tromaville Nazi
- Bill Weil
- Tromaville Nazi
- David Berk
- Person at the Hospital
- Danielle Breda
- Person at the Hospital
- Matthew Burris
- Person at the Hospital
- John Cashin
- Hospital Orderly / Tromaville Citizen
- Anthony Cosumano
- Person at the Hospital
- Mathew Dooley
- Person at the Hospital
- George Ernst
- Person at the Hospital
- Eleanor Gardner
- Person at the Hospital
- Will Garmon
- Person at the Hospital
- Despina Gatanas
- Person at the Hospital
- Jacqueline Haro
- Person at the Hospital
- Andrea Hawthorne
- Person at the Hospital
- Ian Faith
- Person at the Hospital
- Kyle Hicks
- Person at the Hospital
- Alison Holselan
- Person at the Hospital
- Matt Janus
- Person at the Hospital
- Adam King
- Person at the Hospital
- Eric Michael Kochmer
- Crazy Doctor
- Matt Levin
- Person at the Hospital
- William F. Maher
- Person at the Hospital
- James McGrath
- Person at the Hospital
- Craig McMahon
- Person at the Hospital
- Josh Menagh
- Person at the Hospital
- Judith Mendez
- Person at the Hospital
- Jessica Napier
- Person at the Hospital
- Erin O'Reilly
- Person at the Hospital
- Jessica C. Silver
- Person at the Hospital
- Joe Weil
- Person at the Hospital
- Jon Perry
- Person at the Hospital
- Jermaine Phelps
- Person at the Hospital
- Andrew Platt
- Person at the Hospital
- Greta Robinson
- Person at the Hospital
- Anthony Rosen
- Person at the Hospital
- Beth Russoniello
- Person at the Hospital
- Anthony Sample
- Person at the Hospital
- Paul Sandman
- Person at the Hospital
- Robert Shannon
- Person at the Hospital
- Robert Sicarro
- Person at the Hospital
- Tanya Simmons
- Person at the Hospital
- Colin Turner
- Person at the Hospital
- Diana Van Wart
- Person at the Hospital
- Ian Robert Pallak
- Person at the Hospital
- Daniel Brida
- Person at the Hospital
- Jana Winter
- Person at the Hospital
- Lynette Wittman
- Person at the Hospital
- Michael H. Baker Jr.
- Noxie Baby
- Charlotte Haug
- Toxie's Mom
- Rory Quinn
- Toxie Baby
- Andrea Biro
- Kabuki-Baby
- Gerald Blakey
- Protester at Clinic
- Matthew Goldpaugh
- Tromaville Nazi / Angry Tromaville Citizen / Amortvillian
- Margaret G. Ringwood
- Tromaville Citizen / Protestor at Clinic
- Arik Sansivero
- Protester Baby at Clinic
- Gene Theriault
- Background extra on set
- Mark C. Adams
- Bystander
- Gil Brenton
- Warren
- Ian Capone
- Police
- Lenora Claire
- Self
- Timothy Considine
- Nazi with Eye Patch / Janitor on Fire (uncredited)
- Don Deich
- Vampire in Amortville / Dead Body (uncredited)
- Revé Douglas
- Citizen
- Brendan Flynt
- Tromaville Citizen
- Devin Hamilton
- Bar Mitzvah Guy
- Hugh Hefner
- President of the United States
- Jason Horton
- Various roles
- Adam Jahnke
- Tromaville Citizen
- Charlotte Kaufman
- Tromaville / Amortville Citizen (uncredited)
- Lloyd Kaufman
- Man in Public Service Announcement
- Brian Macaya
- Tromaville Citizen
- Joy E. Reed
- Juggler
- James T. Warbington
- Street Punk
