- Gabriel Byrne
- Â Christopher Columbus 4 episodes, 1985
- Rossano Brazzi
- Â Diego Ortiz De Vilhegas 4 episodes, 1985
- Virna Lisi
- Â Dona Moniz Perestrello 4 episodes, 1985
- Oliver Reed
- Â Martin Pinzon 4 episodes, 1985
- Raf Vallone
- Â Jose Vizinho 4 episodes, 1985
- Max von Sydow
- Â King John of Portugal 4 episodes, 1985
- Eli Wallach
- Â Father Hernando De Talavera 4 episodes, 1985
- Nicol Williamson
- Â King Ferdinand 4 episodes, 1985
- Faye Dunaway
- Â Queen Isabella of Spain 4 episodes, 1985
- Michel Auclair
- Â Luis De Santangel 4 episodes, 1985
- William Berger
- Â Francisco De Bobadilla 4 episodes, 1985
- Keith Buckley
- Â De Torres 4 episodes, 1985
- Mark Buffery
- Â Bartholomo Colombo 4 episodes, 1985
- Anne Canovas
- Â Beatriz Enriquez 4 episodes, 1985
- Elpidia Carrillo
- Â Coana 4 episodes, 1985
- Massimo Girotti
- Â Duke Medina Celi 4 episodes, 1985
- Larry Lamb
- Â Don Castillo 4 episodes, 1985
- Stefano Madia
- Â Federico 4 episodes, 1985
- Audrey Matson
- Â Dona Felipa Perestrello 4 episodes, 1985
- Murray Melvin
- Â Father Linares 4 episodes, 1985
- Jack Watson
- Â Father Marchena 4 episodes, 1985
- Hal Yamanouchi
- Â Guacanabo 4 episodes, 1985
- Claudio Aliotti
- Â Diego as an Adult 4 episodes, 1985
- Patrick Bauchau
- Â Don Rodrigo 4 episodes, 1985
- Kasimir Berger
- Â Diego as a Child 4 episodes, 1985
- Sal Borgese
- Â Juan 4 episodes, 1985
- Charles Borromel
- Â Xarmiento 4 episodes, 1985
- Tony Camilleri
- Â Riquelme 4 episodes, 1985
- Scott Coffey
- Â Vallejo 4 episodes, 1985
- Cyrus Elias
- Â Alaminos 4 episodes, 1985
- Francesco Lattuada
- Â De Triana 4 episodes, 1985
- Patrick Longhi
- Â Ferdinand 4 episodes, 1985
- Alexander Lopez
- Â Diego Taino 4 episodes, 1985
- Antonio Marsina
- Â Vicente Pinzon 4 episodes, 1985
- David Mills
- Â Dr. Chanca 4 episodes, 1985
- Lino Mintoff
- Â De Gamma 4 episodes, 1985
- Brizio Montinaro
- Â Ocampo 4 episodes, 1985
- Joseph Murphy
- Â Escobedo 4 episodes, 1985
- Luca Orlandini
- Â Diego as a Teenager 4 episodes, 1985
- Iris Peynado
- Â Selina 4 episodes, 1985
- Jean-François Poron
- Â Alonso De Mardan 4 episodes, 1985
- Erik Schumann
- Â Benguela 4 episodes, 1985
- Gregory Snegoff
- Â Francisco Pinzon 4 episodes, 1985
- John Suda
- Â Ruiz 4 episodes, 1985
- Sergio Testori
- Â Arias 4 episodes, 1985
- Fabiola Toledo
- Â Dona Maria De Toledo 4 episodes, 1985
- Josefina Vetencourt
- Â Clara De Moya 4 episodes, 1985
- Heinz Weiss
- Â Noscomb 4 episodes, 1985
- David de Keyser
- Â Of various roles 4 episodes, 1985
- Robert Rietty
- Â Of various roles 4 episodes, 1985
- Anna Cachia
- Â Wife of Sea Captain 1 episode, 1985
- Franco Fantasia
- Â Captain Valdez (uncredited) 1 episode, 1985