- Dolly Parton
- Angel
- Jenifer Lewis
- Margeline
- Josh Segarra
- Pastor Christian Hathaway
- Jeanine Mason
- Felicity Sorenson
- Mary Lane Haskell
- Jenna Hathaway
- Treat Williams
- Carl Pellam
- Christine Baranski
- Regina
- Mark Daniel Chmiel
- Phil the Mailman
- Donald Corren
- Dr. Marshall
- Mary Donnelly Haskell
- Lenore
- Brandon Hudson
- Randy
- Matthew Johnson
- Mack
- Selah Kimbro Jones
- Violet
- Vivian Nixon
- Bessie
- Brandon O'Neal
- Andy
- Douglas Sills
- Jack Fuller
- Carol Swarbrick
- Granny Hoover
- Hailey Rose Walsh
- Teenage Regina
- Andrew Joseph Brodeur
- Teenage Carl
- Aidan Dacy Carberry
- Handsome Stranger
- Stella Grubb
- Six-Year-Old Regina
- Erin Kristina Banks
- Teenage Margeline
- Terry Beeman
- Toothless Bearded Man
- Kim Hale
- Pie Woman / Diner Cook
- Yvonne Valadez
- Dr. Martinez
- Stephen Caudill
- Dr. Lundquist
- Cruz Abelita
- Little Boy
- Braxton Alexander
- Kenny
- Jacob Moran
- Gilbert
- Lariah Alexandria
- Young Margeline
- Stacy Ann Rose
- Rose
- Chad Geiger
- Dancer
- Luke Kamppila
- Dancer
- Bubba Dean Rambo
- Dancer
- Alissa Tucker
- Dancer
- Christopher Tsattalios
- Dancer
- Kar Will
- Dancer
- Alex Wong
- Dancer
- A.C. Wilson
- Dancer
- Anthony Ranches
- Dancer
- Tristan Joseph Hill
- Dancer
- Ivan A. Gomez
- Dancer
- Ben Blevins
- Dancer
- Sheerod Tate
- Dancer
- Justin Edwards
- Dancer
- Bryce Speaker
- Dancer
- Marissa Neola
- Dancer
- Nicole Lewandowski
- Dancer
- Kristin Talley
- Dancer
- Lillie Martin
- Dancer
- Dominique Harris
- Dancer
- Gabby Fenimore
- Dancer
- Savoy Bailey
- Dancer
- Kelly Verzi
- Dancer
- Jean-Victor Mackie
- Dancer
- Lola Simone
- Dancer
- Kyla Gibson
- Dancer
- Layla Alexis White
- Dancer
- Elijah Oliver
- Dancer
- Noah Kazeem-Riley
- Dancer
- Aaron Nedrick
- Dancer
- Todd Hanebrink
- Dancer
- Kenny Waymack Jr.
- Dancer
- Quentin Avery Brown
- Dancer
- Nateli Ruiz
- Dancer
- Elaine Wadsworth
- Dancer
- Katie Turner
- Dancer
- Kara Kimmer
- Dancer
- Mari Kasuya
- Dancer
- Megan Dominique Prout
- Dancer
- Nikki Tomlinson
- Dancer
- Navaeh Walton
- Dancer
- Tyson Anthony Hill
- Dancer
- Gabriel Villafranco
- Dancer
- Bryce Stewart
- Dancer
- Grace Hazelett
- Dancer
- Sadie Hazelett
- Principal Dancer
- Daniel Pietruszka
- Dancer
- Jene Moore
- Dancer
- Reif Howey
- Dancer
- Bobby Kelly
- Dancer
- Mylie Stone
- Dancer
- Ania Morrow
- Dancer
- Sophia Davila
- Dancer
- McKenzi Brooke
- Dancer
- Christopher L. Plunkett
- Dancer
- Ahmed Zakzouk
- Dancer
- Evangeline Miller
- Dancer
- Mason Turnham
- Dancer
- Christopher Scott
- Dancer
- Ava Bokelberg
- Ava / Principal Dancer
- Devon Szlanka
- Principal Dancer
- Brenda Findley
- (uncredited)
- Uriah Love
- Dancer
- LC Powell
- Additional Voices
