- Pat O'Brien
- Dave Logan
- Beverly Roberts
- Jean Logan
- Ross Alexander
- Tom Collins
- Humphrey Bogart
- Hap Stuart
- Marie Wilson
- Sunny Avery
- Joseph Crehan
- Jim Horn
- Joe King
- Mr. Pierson
- Addison Richards
- Mr. B.C. Hill
- Ruth Robinson
- Mother Brunn
- Henry B. Walthall
- Dad Brunn
- Carlyle Moore Jr.
- Radio Operator on Clipper
- Lyle Moraine
- Co-pilot on Clipper
- Dennis Moore
- Engineer on Clipper
- Wayne Morris
- Navigator on Clipper
- Alexander Cross
- Bill Andrews
- William Wright
- Pilot
- Kenneth Harlan
- Department of Commerce Inspector
- Anne Nagel
- Secretary
- Marjorie Weaver
- Secretary
- Milburn Stone
- Radio Operator
- Owen King
- Radio Operator
- Irving Bacon
- Charlie - the Janitor
- George Beranger
- Waiter
- John Butler
- Second Commerce Inspector
- Glen Cavender
- Pan American Union Waiter
- Joe Cunningham
- Jack - a Weatherman
- Hal K. Dawson
- Airplane Designer
- Ralph Dunn
- Plane Announcer at Miami Airport
- Bill Elliott
- Pilot
- Frank Faylen
- Weatherman
- Jonathan Hale
- State Department Official
- Jack Hatfield
- Reporter
- Milton Kibbee
- Mechanic
- Shirley Lloyd
- Eadie - Horn's Secretary
- John Marston
- Airplane Designer
- Walter Miller
- Instructor
- Thomas Pogue
- Key West Speaker
- Georges Renavent
- Pan American Union Speaker
- John Graham Spacey
- Australian Broadcaster
- Edwin Stanley
- Airplane Designer
- Houseley Stevenson
- Doctor
- Harland Tucker
- Airplane Designer
- Guy Usher
- State Department Official
- Emmett Vogan
- Airplane Designer
- Pierre Watkin
- Secretary of State
