- John C. Reilly
- Â Dr. Steve Brule / ... 24 episodes, 2010-2016
- Carol Kraft
- Â Carol Krabbit 10 episodes, 2010-2016
- Doug Foster
- Â Doug Prishpreed 9 episodes, 2010-2016
- Scott Stewart
- Â Scott Clam 7 episodes, 2014-2017
- Robert Axelrod
- Â Terry Bruge-Hiplo 7 episodes, 2010-2016
- Nancy Munoz
- Â Doris Pringle-Brule-Salahari / ... 6 episodes, 2010-2016
- Eric Wareheim
- Â Wayne Skylar / ... 5 episodes, 2010-2014
- Tim Heidecker
- Â Jan Skylar 5 episodes, 2010-2014
- Bill Carey
- Â Hippy Joel 5 episodes, 2010-2016
- Albert Hartfeld
- Â Denny 5 episodes, 2010-2016
- David Liebe Hart
- Â Self 5 episodes, 2010-2017
- Danny Allen
- Â Brown / ... 4 episodes, 2012-2016
- Pablo Pumphrey
- Â Pablo Myers 4 episodes, 2012-2016
- Ron Don Vonlonte
- Â Ron Don Volante 4 episodes, 2012-2014
- Rae Sunshine Lee
- Â Susan Brule / ... 3 episodes, 2010-2014
- Tiny Ron
- Â Fake Dad / ... 2 episodes, 2010-2014
- Bob Raynor
- Â Uncle Gary 2 episodes, 2010-2014
- Joseph Makkar
- Â Mobin 2 episodes, 2012-2014
- Maria Bamford
- Â Cynthia Driscoll 1 episode, 2010
- Ronald Walter Barker
- Â Ronald Barker 1 episode, 2012
- Donna Rusch
- Â Linda Barrelli 1 episode, 2014
- Jonny Bowden
- Â Self 1 episode, 2010
- Gary Lecroix
- Â Self 1 episode, 2012
- Martin Faigin
- Â Self 1 episode, 2012
- Daniel M. Hooper
- Â Self 1 episode, 2014
- Irving Orozco
- Â Self 1 episode, 2014
- Bob Baker
- Â Self 1 episode, 2010
- Don Etkes
- Â Self 1 episode, 2010
- Ronnie Rodriguez
- Â Self 1 episode, 2012
- Paulette Hunnewell
- Â Self 1 episode, 2012
- Jolie Mason
- Â Self 1 episode, 2012
- Adora Dei
- Â Doctor 1 episode, 2014
- Becky Brown
- Â Spanish Teacher 1 episode, 2016
- David Falk
- Â Self 1 episode, 2012
- Amy Porter
- Â Self 1 episode, 2012
- Kevin Lee
- Â Jeffrey Brown 1 episode, 2014
- Cheryl A. Smith
- Â Self 1 episode, 2014
- Chris Bealer
- Â Daycare Boy 2 episodes, 2014-2016
- Christine Dupree
- Â Girl in the Dream 1 episode, 2016
- Mauricio Solis
- Â Goon 1 episode, 2012
- David Jurasevich
- Â Self 1 episode, 2012
- Gwen Holloway
- Â ER Doctor 1 episode, 2014
- Jayce Bertrand
- Â Daycare Boy 2 episodes, 2014-2016
- Donnie Marhefka
- Â Actor 1 episode, 2016
- Sophiah Koikas
- Â Girl in the Dream 1 episode, 2016
- Curtis Christlieb
- Â Self 1 episode, 2016
- Ursula Heinle
- Â Self 1 episode, 2010
- Jose G. Lopez
- Â Janitor 1 episode, 2010
- Sean Roach
- Â Self 1 episode, 2012
- Darin Rossi
- Â Self 1 episode, 2014
- Rolando W. Wolovich
- Â Self 1 episode, 2014
- Sheila Marie
- Â Hot Girl in Blue Dress 1 episode, 2016
- Fabian Alomar
- Â Prisoner 1 episode, 2016
- Curtis Duffy
- Â Self 1 episode, 2016
- Cory Roberts
-  Piñata Contestant 1 episode, 2016
- Pamela Finney
- Â Chef 1 episode, 2016
- Kevin Bielinski
- Â Prison Warden 1 episode, 2016
- Gene Carrothers
- Â Self 1 episode, 2016
- Sandy Sanders
- Â Self 1 episode, 2010
- Sheri Smith
- Â Fertility Clinic Nurse 1 episode, 2012
- Vanar Kovayan
- Â Daycare Boy 2 episodes, 2014-2016
- Bob Rummler
- Â Mario 1 episode, 2016
- Lihua Zhang
- Â Self 1 episode, 2016
- Oberon Zell-Ravenheart
- Â Self 1 episode, 2014
- Lindsay McGrail
- Â ER Nurse 1 episode, 2014
- Laine Lasanta
- Â Self 1 episode, 2014
- Cici Leah Campbell
- Â Metal Band Groupie 1 episode, 2016
- Ricardo I. Cerezo
- Â Sketch Artist 1 episode, 2016
- Atsushi Watanabe
- Â Sushi Chef 1 episode, 2010
- June Mock
- Â Doctor 1 episode, 2014
- Libby Smith
- Â Spelling Bee Judge 1 episode, 2016
- Gene Minero
- Â Daycare Boy 2 episodes, 2014-2016
- Andrew Tenorio
- Â Spelling Bee Boy 1 episode, 2016
- Julio Umana
- Â Daycare Boy 2 episodes, 2014-2016
- Dana Michael Woods
- Â Daycare Boy 2 episodes, 2014-2016
- Dillaran Martin
- Â Self (uncredited) 1 episode, 2010
- Stephan D. Gill
- Â Steve Davis (uncredited) 1 episode, 2010
- Del Zamora
- Â Tantric Yoga Student (uncredited) 1 episode, 2012
- Karen E. Wright
- Â Yoga Student (uncredited) 1 episode, 2012
- Sunit Gupta
- Â Blackjack Player (uncredited) 1 episode, 2012
- Bogdan Szumilas
- Â Camera Operator (uncredited) 1 episode, 2014
- D.A. Sandoval
- Â Betting Counter Ticket Person (uncredited) 1 episode, 2014
- Alexana Thomas
- Â Passenger (uncredited) 1 episode, 2014
- Mark Casimir Dyniewicz Jr.
- Â Egg Eating Man (uncredited) 1 episode, 2016
- Geoffrey Gould
- Â Band audience member (uncredited) 1 episode, 2016
- Doby Daenger
- Â Rock Chick (uncredited) 1 episode, 2016
- Rosalio Garcia
- Â Police Station Visitor (uncredited) 1 episode, 2016
- Emmet Flores
- Â Inmate (uncredited) 1 episode, 2016