- Jakobi Alvin
- Young Darrell Barnes
- Suzzanne Douglas
- Mrs. Davis
- Thomas Staten
- Young Andre 'Dre' Newell
- Karen Issac
- Ms. Brown
- Summer Valentine
- Angelina
- Irma P. Hall
- Grandma Barnes
- Dennis L.A. White
- Dre as an Adult
- Sean Riggs
- Darrell as an Adult
- Shannon Dorsey
- Nichole
- Tony Todd
- Curtis the Diabolical / FBI Agent
- Kendia Jones
- Reba Jones
- Ernest Butts
- Troy
- Sticky Fingaz
- Craig
- Nicoye Banks
- Goldie
- Brandon Ruckdashel
- Marty Levine
- Mari White
- Jennifer
- John Frisby
- Vince
- Ming Leone
- Marty's Masseuse
- Tom Dwyer
- Dean Houseman
- Irv Slifkin
- Jennifer's Father
- Demetria Bailey
- Jennifer's Mother
- Ted Taylor
- Segar Thuns
- David Winning
- Scott Haragon
- Jessica Czop
- Darrell's Secretary
- Kaki Burns
- Marty's Female Companion
- J. Center
- Charles Ryne
- Munir Kreidie
- Obul Metha
- Raw Leiba
- Balu
- Ted LeBlang
- Gordon Eissenhart
- Brian Anthony Wilson
- McCormick
- Ted Ferguson
- John Morris
- Elizabeth Camacho
- Sexy Flight Attendant
- Howard Rubin
- Neighborhood Cop
- Patty Jackson
- Radio Voice #1
- José Alvarez
- Bass and Montgomery Guard
- Neelah Shah
- Obul's Secretary
- Monica Peters
- Darrell's London Secretary
- Steve Izant
- Dr. Alfred
- Charli Baltimore
- News Reporter
- DC Todd
- Radio Voice #2
- Gil Hamm Jr.
- Keyboard Church Musician
- Nathan Jacobs
- Drums
- Tyrone Blandford
- Bass
- Stephen Bernstein
- Church Visitor
- Maya Dajón
- College Graduate
- Nancy Gilliam
- Church Visitor
- Xander Goode
- Boy at Hotel Explosion
- Marqus Kane
- Bouncer
- Nacone Martin
- Bar Patron
- Dorothy Meyers
- Sister of Graduate / Restaurant Patron (uncredited)
- Dan Van Wert
- College Graduate
- Anthony M. Walker
- Bar Associate / Church Member (uncredited)
- Whitney Wilcox
- Child in Classroom
