- Katharine Hepburn
- Susan Vance
- Cary Grant
- David Huxley
- Charles Ruggles
- Major Applegate
- Walter Catlett
- Slocum
- Barry Fitzgerald
- Aloysius Gogarty
- May Robson
- Aunt Elizabeth
- Fritz Feld
- Dr. Lehman
- Leona Roberts
- Mrs. Gogarty
- George Irving
- Alexander Peabody
- Tala Birell
- Mrs. Lehman
- Virginia Walker
- Alice Swallow
- John Kelly
- Elmer
- Ruth Adler
- Minor Role
- Adeline Ashbury
- Mrs. Peabody
- Asta
- George the Dog
- William 'Billy' Benedict
- David's Caddy
- Billy Bevan
- Joe - Bartender
- Stanley Blystone
- Doorman
- Ward Bond
- Motorcycle Cop at Jail
- Ralph Brooks
- Nightclub Table Patron
- Harry Campbell
- Minor Role
- Jack Carson
- Circus Roustabout
- D'Arcy Corrigan
- Professor LaTouche
- William Corson
- Minor Role
- Evelyne Eager
- Circus Performer
- Judith Ford
- Hatcheck Girl
- Billy Franey
- Butcher
- Jack Gardner
- Deliveryman
- Edward Gargan
- Zoo Official
- Frances Gifford
- Minor Role
- C. 'Tex' Gilmore
- Minor Role
- Herschel Graham
- Waiter
- Duke Green
- Minor Role
- Paul Guilfoyle
- Minor Role
- Geraldine Hall
- Maid
- George Humbert
- Louis - Headwaiter
- Karl 'Karchy' Kosiczky
- Midget
- Lorraine Krueger
- Minor Role
- Richard Lane
- Circus Manager
- Nissa the Leopard
- Baby
- Dorothy Lloyd
- Minor Role
- Buck Mack
- Zoo Official
- Teddy Mangean
- Minor Role
- Frank Marlowe
- Joe
- Jeanne Martel
- Cigarette Girl
- Pat O'Malley
- Deputy
- Eleanor Peterson
- Circus Performer
- Paul Power
- Nightclub Patron
- Buster Slaven
- Peabody's Caddy
- Larry Steers
- Nightclub Patron
- Jean Stevens
- Minor Role
- Bobby Stone
- Minor Role
- Jack Stoney
- Minor Role
- Edward Thomas
- Bartender
- Ida Vollmar
- Minor Role
- Crawford Weaver
- Minor Role
- Robert Weldon
- Minor Role
- Pat West
- Mac
- Cynthia Westlake
- Minor Role
