- Gretchen Krich
- Mother
- Sullivan Brown
- Guy Maddin / Young
- Maya Lawson
- Sis
- Jake Morgan-Scharhon
- Chance Hale / Wendy Hale (as Katherine E. Scharhon)
- Todd Moore
- Father
- Andrew Loviska
- Savage Tom
- Kellan Larson
- Neddie
- Erik Steffen Maahs
- Guy Maddin / Older
- Cathleen O'Malley
- Mother / Young
- Clayton Corzatte
- Father / Old
- Susan Corzatte
- Mother / Old
- Megan Murphy
- Murderous Sister
- Annette Toutonghi
- Murderous Sister
- David Lobo
- Oarsman
- Eric Lobo
- Oarsman
- Sarah Harlett
- Adopting Couple
- Dan Tierney
- Adopting Couple
- David Armo
- Orphan
- Erica Badgely
- Orphan
- Riley Calcagno
- Orphan
- Jesa Chiro
- Orphan
- Munya Chiro
- Orphan
- Bailey Gibart
- Orphan
- Frank Hughes
- Orphan
- AnnieRose Kafer
- Orphan
- Emma Kelley
- Orphan
- Eleanor Kopf
- Orphan
- Sam Kopf
- Orphan
- Charlie Lachow
- Orphan
- Sam Lachow
- Orphan
- Maia Lee
- Orphan
- Emma Mercer
- Orphan
- Lucia Moser
- Orphan
- Madeleine Moser
- Orphan
- Eli Pruzan
- Orphan
- Connor Russell
- Orphan
- Electra Fire Scott
- Orphan
- Vincent Scott
- Orphan
- Iris Seiwerath
- Orphan
- Ruby Seiwerath
- Orphan
- Olivia Spokoiny
- Orphan
- Maya Sugarman
- Orphan
- Augustine Vanden Brulle
- Orphan
- Isabella Rossellini
- Narrator
- Clara Grace Svenson
- Baby Mother
- Anna Wichman
- Orphan
